Browsing Faculté de pharmacie – Travaux et publications by Title
Now showing items 26-45 of 95
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Data-adaptive longitudinal model selection in causal inference with collaborative targeted minimum loss-based estimation
(Wiley, 2019)Causal inference methods have been developed for longitudinal observationalstudy designs where confounding is thought to occur over time. In particular,one may estimate and contrast the population mean counterfactual outcomeunder specific exposure ... -
De la mesure au sens de la mesure : l’économie scripturaire du sida et de son traitement en République centrafricaine (RCA)
(Société d'Anthropologie des Connaissances, 2016-06-30)Pour donner sens à la mesure, il faut la rapporter à un système de valeurs qui en permet l’évaluation et le jugement. Voilà le parti pris théorique qui sous-tend cet article consacré aux pratiques d’écriture de la lutte contre le sida à partir d’une ... -
Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion
(American Chemical Society, 2022-12-14)Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply penetrating into dense tissues of the CNS could potentially transform the management of neurological diseases. In the present study, we investigated the interaction of ... -
Differences in platelet-rich plasma composition influence bone healing
(Wiley, 2021)Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and ... -
Dose-dependent pharmacokinetics of ropivacaine in anesthetized rabbits : absence of changes in protein binding
(Annex Publishers, 2019-04-25)Objective: The primary objectives of this study were to investigate the in vivo pharmacokinetics and in vitro plasma protein binding of ropivacaine at the concentration range observed after intravenous administration of different doses in anesthetized ... -
Drug-loaded nanocarriers : passive targeting and crossing of biological barriers
(2012-12)Poor bioavailability and poor pharmacokinetic characteristics are some of the leading causes of drug development failure. Therefore, poorly-soluble drugs, fragile proteins or nucleic acid products may benefit from their encapsulation in nanosized ... -
Effect of polymer architecture on Curcumin 1 encapsulation and release from PEGylated polymer nanoparticles: toward a drug delivery nano-platform to the CNS
(2015-10-01)We developed a nanoparticles (NPs) library from poly(ethylene glycol)–poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative ... -
Effect of Polymer Architecture on the Structural and Biophysical Properties of PEG-PLA Nanoparticles
(2015-05-01)Polymers made of poly(ethylene glycol) chains grafted to poly(lactic acid) chains (PEG-g-PLA) were used to produce stealth drug nanocarriers. A library of comb-like PEG-g-PLA polymers with different PEG grafting densities was prepared in order to obtain ... -
Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
(Elsevier, 2018-10-11)We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ... -
Electrostatic screening length in “soft” electrolyte solutions
(American Chemical Society, 2019-07-30)Using the Surface Forces Apparatus on solutions of polymeric ions, the effect of specific ion–ion correlations is evaluated on the characteristic decay length, λ, of screened electrostatic interactions between charged surfaces. Electrolyte solutions ... -
Estimating treatment importance in multidrug-resistant tuberculosis using Targeted Learning : an observational individual patient data network meta-analysis
Estimating MDR-TB treatment importance using TMLE
(Wiley, 2019)Persons with multidrug‐resistant tuberculosis (MDR‐TB) have a disease resulting from a strain of tuberculosis (TB) that does not respond to at least isoniazid and rifampicin, the two most effective anti‐TB drugs. MDR‐TB is always treated with multiple ... -
Factors associated with psychotropic drug use among community-dwelling older persons: A review of empirical studies
(2004)BACKGROUND:In the many descriptive studies on prescribed psychotropic drug use by community-dwelling older persons, several sociodemographic and other factors associated with drug use receive inconsistent support.METHOD:Empirical reports with data on ... -
Head‐to‐Head comparison of consensus‐recommended platelet function tests to assess P2Y12 Inhibition : insights for multi‐center trials
(MDPI, 2020)The vasodilator‐associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted ... -
Hotspot or blind spot? Historical perspectives on surveillance and response to epidemics in the Central African Republic
(Springer, 2020-02-12)Objectives The Central African Republic (CAR), a site of recurrent disease emergence, developed a noteworthy epidemiological surveillance system from the colonial period, but its health measures have remained among the world’s lowest. To understand ... -
Hydration forces at solid and fluid biointerfaces
(American Vacuum Society, 2016-01)We review the different molecular mechanisms giving rise to the repulsive hydration force between biologically relevant surfaces such as lipid bilayers and bio-ceramics. As we will show, the hydration force manifests itself in very different and ... -
Impact of discretization of the timeline for longitudinal causal inference methods
(Wiley, 2020-09-01)In longitudinal settings, causal inference methods usually rely on a discretization of the patient timeline that may not reflect the underlying data generation process. This paper investigates the estimation of causal parameters under discretized ... -
Implications of the antiplatelet therapy gap left with discontinuation of prasugrel in Canada
(Elsevier, 2020-12-16)Background The current Canadian Cardiovascular Society antiplatelet therapy guidelines recommend the use of ticagrelor or prasugrel over clopidogrel as first-line platelet P2Y12 receptor antagonists for treatment of moderate- to high-risk acute coronary ... -
(In)stability of ligands at the surface of inorganic nanoparticles : a forgotten question in nanomedicine?
(Elsevier, 2022-06-14)Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine. Various core materials and shapes are explored, but they all display a common hybrid structure, with organic ligands on their surface. These ligands play a key role ... -
Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery
(Taylor & Francis, 2018-11-13)Inflammatory mechanisms are activated, and thrombotic complications occur during the initial months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet activation and platelet–leukocyte interactions after CABG are ... -
Insiders, smart drugs et pharmaceuticalisation : éléments pour une typologie de la nouvelle déviance conformiste
(Département de sociologie de l’Université du Québec à Montréal & Athéna éditions, 2016)La multiplication des usagers et usagères des smart drugs sur les campus universitaires, des go-pills dans l’armée ou encore des coast-to-coast chez les camionneurs de longue distance invite à revisiter la légitimité croissante des « usages adaptatifs ...