Browsing Faculté de pharmacie – Travaux et publications by Title
Now showing items 87-95 of 95
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Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
(Frontiers media, 2021-02-11)Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ... -
A tutorial on dealing with time‐varying eligibility for treatment: Comparing the risk of major bleeding with direct‐acting oral anticoagulants vs warfarin
(Wiley, 2020-08-18)In this tutorial, we focus on the problem of how to define and estimate treatment effects when some patients develop a contraindication and are thus ineligible to receive a treatment of interest during follow-up. We first describe the concept of ... -
Tyrosine-based rivastigmine-loaded organogels in the treatmant of Alzheimer's disease
(2010-08)Organogels can be prepared by immobilizing an organic phase into a threedimensional network coming from the self-assembly of a low molecular weight gelator molecule. In this work, an injectable subcutaneous organogel system based on safflower oil and ... -
Understanding and diagnosing the potential for bias when using machine learning methods with doubly robust causal estimators
(SAGE, 2018-05-02)Data-adaptive methods have been proposed to estimate nuisance parameters when using doubly robust semiparametric methods for estimating marginal causal effects. However, in the presence of near practical positivity violations, these methods can produce ... -
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic acid) diblock polymer (PEG-b-PLA) ... -
Universal cures for idiosyncratic illnesses: a genealogy of therapeutic reasoning in the mental health field
(SAGE Publications, 2014-08)Over the past decades, there has been a significant increase in prescriptions of psychotropic drugs for mental disorders. So far, most of the explanations of the phenomenon have focused on the process of medicalization, but little attention has been ... -
Unraveling the correlations between conformation, lubrication, and chemical stability of bottlebrush polymers at interfaces
(American Chemical Society, 2017-09-29)In the present study, we monitored the conformation and chemical stability of a hydrophilic bottlebrush (BB) polymer in pure water and buffered saline solutions. We correlated these parameters to lubricating and wear protecting properties. Using the ... -
Wear protection without surface modification using a synergistic mixture of molecular brushes and linear polymers
(American Chemical Society, 2017-01-10)We describe the design of lubricating and wear protecting fluids based on mixtures of bottlebrushes (BB) and linear polymers solutions. To illustrate this concept we used hyaluronic acid (HA) - a naturally occurring linear polyelectrolyte, and a water ...