RSS 1.0Faculté de pharmacie - Travaux et publications
Bienvenue dans la collection Travaux et publications de la Faculté de Pharmacie. Vous y trouverez des articles publiés par les professeurs, chargés de cours et étudiants de cette unité, de même que d'autres types de documents produits par les professeurs.
NOTE : Cette collection ne comprend pas les thèses et mémoires et d’autres types de production étudiante qui se retrouvent - et doivent être déposés - respectivement dans les collections Thèses et mémoires et Production étudiante de l'unité.
Recent Submissions
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Intermolecular interactions between Bottlebrush Polymers boost the protection of surfaces against frictional wear
(ACS Publications, 2018-05-30)Polymers exhibiting the bottlebrush (BB) architecture have excellent lubricating properties. However, to motivate their use in real life systems, they must also protect surfaces against frictional damage. In this article, we synthesized a library of ... -
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic acid) diblock polymer (PEG-b-PLA) ... -
Interaction forces between pegylated star-shaped polymers at mica surfaces
(American Chemical Society, 2017-08-03)We present a study focused on characterizing the interaction forces between mica surfaces across solutions containing star-shaped polymers with cationic ends. Using the Surface Forces Apparatus, we show that the interaction forces in pure water between ... -
Non-covalent formulation of active principles with dendrimers: current state-of-the-art and prospects for further development
(Elsevier, 2017-09-06)During the last three decades, dendrimers, nano-sized highly-branched fractal-like symmetrical macromolecules, have been intensively studied as promising candidates for application as drug-delivery carriers. Among other important characteristics arising ... -
Quantification of peptides in human synovial fluid using liquid chromatography–tandem mass spectrometry
(Elsevier, 2018-04-06)A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides are BQ123 Cyclo(-D-Trp-D-A ... -
Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
(American Chemical Society, 2018-01-29)Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block copolymers present certain advantages ... -
Release kinetics from nano-inclusion-based and affinity-based hydrogels: A comparative study
(Elsevier, 2017-06-15)In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), nanogels made of ... -
Hydration forces at solid and fluid biointerfaces
(American Vacuum Society, 2016-01)We review the different molecular mechanisms giving rise to the repulsive hydration force between biologically relevant surfaces such as lipid bilayers and bio-ceramics. As we will show, the hydration force manifests itself in very different and ... -
Unraveling the correlations between conformation, lubrication, and chemical stability of bottlebrush polymers at interfaces
(American Chemical Society, 2017-09-29)In the present study, we monitored the conformation and chemical stability of a hydrophilic bottlebrush (BB) polymer in pure water and buffered saline solutions. We correlated these parameters to lubricating and wear protecting properties. Using the ... -
Wear protection without surface modification using a synergistic mixture of molecular brushes and linear polymers
(American Chemical Society, 2017-01-10)We describe the design of lubricating and wear protecting fluids based on mixtures of bottlebrushes (BB) and linear polymers solutions. To illustrate this concept we used hyaluronic acid (HA) - a naturally occurring linear polyelectrolyte, and a water ...
