Browsing Faculté de pharmacie – Travaux et publications by Issue Date
Now showing items 1-20 of 78
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Antiplatelet therapy in atherothrombotic diseases : similarities and differences across guidelines
(Frontiers media, 2022-04-27)Antiplatelet therapy, mainly consisting of aspirin and P2Y12 receptor antagonists, is the cornerstone of the pharmacological treatment and prevention of atherothrombotic diseases. Its use, especially in secondary cardiovascular prevention, has ... -
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults
(Frontiers Media, 2022-02-21)The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ... -
Antiplatelet therapy for atherothrombotic disease in 2022 : from population to patient-centered approaches
(Frontiers Media, 2022-01-28)Antiplatelet agents, with aspirin and P2Y12 receptor antagonists as major key molecules, are currently the cornerstone of pharmacological treatment of atherothrombotic events including a variety of cardio- and cerebro-vascular as well as peripheral ... -
A randomized double-blind feasibility study comparing cetirizine and diphenhydramine in the prevention of paclitaxel-associated infusion-related reactions : the PREMED-F1 study
(Springer, 2022-01-08)Purpose. Cetirizine is a less sedative alternative to diphenhydramine for the prevention of infusion-related reactions (IRR) to paclitaxel. However, its use remains controversial. In this study, we assessed feasibility for a future definitive ... -
Assessing cardiometabolic parameter monitoring in inpatients taking a second-generation antipsychotic : the CAMI-SGA study – a crosssectional study
(BMJ Publishing Group, 2022)Objectives This study aims to determine the proportion of initial cardiometabolic assessment and its predicting factors in adults with schizophrenia, bipolar disorder or other related diagnoses for whom a second-generation antipsychotic was prescribed ... -
Current and novel antiplatelet therapies for the treatment of cardiovascular diseases
(MDPI, 2021-12-03)Over the last decades, antiplatelet agents, mainly aspirin and P2Y12 receptor antagonists, have significantly reduced morbidity and mortality associated with arterial thrombosis. Their pharmacological characteristics, including pharmacokinetic/pharmacodynamics ... -
The brain-derived neurotrophic factor prompts platelet aggregation and secretion
(American Society of Hematology, 2021-09-21)Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in neurons, and its release and signaling mechanisms have been extensively studied in the central nervous system. Large quantities of BDNF have been reported in ... -
Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function : communication from the ISTH SSC Subcommittee on Platelet Physiology
(Wiley, 2021-09-12)Flow cytometry is increasingly used in the study of platelets in inherited and acquired disorders of platelet number and function. However, wide variation exists in specific reagents, methods, and equipment used, making interpretation and comparison ... -
Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment
(Frontiers media, 2021-09-07)Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), ... -
Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer’s patients
(2021-08-20)Introduction: Acetylcholinesterase inhibitors (AChEIs) are commonly used to treat mild to moderate cases of Alzheimer disease (AD). To the best of our knowledge, there has been no study estimating the risk of bleeding and cardiovascular events in ... -
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
(Frontiers media, 2021-02-11)Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ... -
Start small : how nanomedicine could alleviate the burden of rare CNS Diseases
(MDPI, 2021-01-30)The complexity and organization of the central nervous system (CNS) is widely modulated by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCSFB), which both act as biochemical, dynamic obstacles impeding any ... -
Platelet quiescence in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery
(Wiley, 2021)BACKGROUND: The optimal antiplatelet strategy for patients with acute coronary syndromes who require coronary artery bypass surgery remains unclear. While a more potent antiplatelet regimen will predispose to perioperative bleeding, it is hypothesized ... -
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patient data meta-analysis
(SAGE, 2021)Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine can be improved by identifying ... -
Differences in platelet-rich plasma composition influence bone healing
(Wiley, 2021)Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and ... -
Implications of the antiplatelet therapy gap left with discontinuation of prasugrel in Canada
(Elsevier, 2020-12-16)Background The current Canadian Cardiovascular Society antiplatelet therapy guidelines recommend the use of ticagrelor or prasugrel over clopidogrel as first-line platelet P2Y12 receptor antagonists for treatment of moderate- to high-risk acute coronary ... -
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
(Frontiers Media, 2020-11-25)Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ... -
Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model
(MDPI, 2020-09-14)Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on ... -
Impact of discretization of the timeline for longitudinal causal inference methods
(Wiley, 2020-09-01)In longitudinal settings, causal inference methods usually rely on a discretization of the patient timeline that may not reflect the underlying data generation process. This paper investigates the estimation of causal parameters under discretized ... -
A tutorial on dealing with time‐varying eligibility for treatment: Comparing the risk of major bleeding with direct‐acting oral anticoagulants vs warfarin
(Wiley, 2020-08-18)In this tutorial, we focus on the problem of how to define and estimate treatment effects when some patients develop a contraindication and are thus ineligible to receive a treatment of interest during follow-up. We first describe the concept of ...
