Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery
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Platelets ; vol. 30, no. 8, pp. 975-981.Publisher(s)
Taylor & FrancisAuthor(s)
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Abstract(s)
Inflammatory mechanisms are activated, and thrombotic complications occur during the initial
months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet
activation and platelet–leukocyte interactions after CABG are of interest. Whole-blood flow cytometry
was performed before, and 4–6 days, one month, and three months after elective CABG in 54 men
with stable coronary artery disease treated with acetylsalicylic acid (ASA). Single platelets and
platelet–leukocyte aggregates (PLAs) among monocytes (P-Mon), neutrophils (P-Neu), and lymphocytes (P-Lym) were studied without and with stimulation by submaximal concentrations of ADP,
thrombin, and the thromboxane analog U46619. White blood cell counts were increased during the
initial postoperative course, and platelet counts were increased after one month. Platelet P-selectin
expression was significantly enhanced at one month when stimulated by thrombin and U46619 and
at three months with ADP and thrombin. All PLAs subtypes were increased at one month without
stimulation in vitro. P-Mon and P-Neu stimulated by ADP, thrombin, or U46619 were significantly
increased one month after the operation but decreased compared to baseline at three months.
Agonist stimulated P-Lyms were increased at one month and remained increased at three months
after ADP stimulation. There was significant platelet activation and formation of PLAs unstimulated
and after agonist stimulation by ADP, thrombin, and a thromboxane analog after CABG in patients
with stable coronary artery disease irrespective of ASA treatment. Changes observed up to three
months after CABG support further studies of the clinical implications of protracted increases in
platelet activation and platelet–leukocyte interactions.
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