Parcourir Faculté de pharmacie – Travaux et publications par auteur·e "Lordkipanidzé, Marie"
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Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer’s patients
(2021-08-20)Introduction: Acetylcholinesterase inhibitors (AChEIs) are commonly used to treat mild to moderate cases of Alzheimer disease (AD). To the best of our knowledge, there has been no study estimating the risk of bleeding and cardiovascular events in ... -
Advances in platelet function testing—light transmission aggregometry and beyond
(MDPI, 2020-08-13)Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light ... -
Antiplatelet therapy for atherothrombotic disease in 2022 : from population to patient-centered approaches
(Frontiers Media, 2022-01-28)Antiplatelet agents, with aspirin and P2Y12 receptor antagonists as major key molecules, are currently the cornerstone of pharmacological treatment of atherothrombotic events including a variety of cardio- and cerebro-vascular as well as peripheral ... -
Antiplatelet therapy in atherothrombotic diseases : similarities and differences across guidelines
(Frontiers media, 2022-04-27)Antiplatelet therapy, mainly consisting of aspirin and P2Y12 receptor antagonists, is the cornerstone of the pharmacological treatment and prevention of atherothrombotic diseases. Its use, especially in secondary cardiovascular prevention, has ... -
Assessing cardiometabolic parameter monitoring in inpatients taking a second-generation antipsychotic : the CAMI-SGA study – a crosssectional study
(BMJ Publishing Group, 2022)Objectives This study aims to determine the proportion of initial cardiometabolic assessment and its predicting factors in adults with schizophrenia, bipolar disorder or other related diagnoses for whom a second-generation antipsychotic was prescribed ... -
Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment
(Frontiers media, 2021-09-07)Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), ... -
The brain-derived neurotrophic factor prompts platelet aggregation and secretion
(American Society of Hematology, 2021-09-21)Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in neurons, and its release and signaling mechanisms have been extensively studied in the central nervous system. Large quantities of BDNF have been reported in ... -
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults
(Frontiers Media, 2022-02-21)The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ... -
Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
Thrombocytopenia in acute coronary syndromes
(Taylor & Francis, 2018-10-22)Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence on the clinical importance of ... -
Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function : communication from the ISTH SSC Subcommittee on Platelet Physiology
(Wiley, 2021-09-12)Flow cytometry is increasingly used in the study of platelets in inherited and acquired disorders of platelet number and function. However, wide variation exists in specific reagents, methods, and equipment used, making interpretation and comparison ... -
Current and novel antiplatelet therapies for the treatment of cardiovascular diseases
(MDPI, 2021-12-03)Over the last decades, antiplatelet agents, mainly aspirin and P2Y12 receptor antagonists, have significantly reduced morbidity and mortality associated with arterial thrombosis. Their pharmacological characteristics, including pharmacokinetic/pharmacodynamics ... -
Differences in platelet-rich plasma composition influence bone healing
(Wiley, 2021)Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and ... -
Head‐to‐Head comparison of consensus‐recommended platelet function tests to assess P2Y12 Inhibition : insights for multi‐center trials
(MDPI, 2020)The vasodilator‐associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted ... -
Implications of the antiplatelet therapy gap left with discontinuation of prasugrel in Canada
(Elsevier, 2020-12-16)Background The current Canadian Cardiovascular Society antiplatelet therapy guidelines recommend the use of ticagrelor or prasugrel over clopidogrel as first-line platelet P2Y12 receptor antagonists for treatment of moderate- to high-risk acute coronary ... -
Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery
(Taylor & Francis, 2018-11-13)Inflammatory mechanisms are activated, and thrombotic complications occur during the initial months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet activation and platelet–leukocyte interactions after CABG are ... -
A meta-analysis of the effect of paper versus digital reading on reading comprehension in health professional education
(American Association of Colleges of Pharmacy, 2021-12-29)Objective. Despite a rise in the use of digital education in health professional education (HPE), little is known about the comparative effectiveness of paper-based reading and its digital alternative on reading comprehension. The objectives of this ... -
Platelet function in aging
(Frontiers Media, 2019-08-07)Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that ... -
Platelet function tests
(Thieme Publishing, 2016-04)Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate ... -
Platelet quiescence in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery
(Wiley, 2021)BACKGROUND: The optimal antiplatelet strategy for patients with acute coronary syndromes who require coronary artery bypass surgery remains unclear. While a more potent antiplatelet regimen will predispose to perioperative bleeding, it is hypothesized ... -
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
(Frontiers Media, 2020-11-25)Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ...
