Browsing Faculté de pharmacie – Travaux et publications by Title
Now showing items 38-92 of 95
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Head‐to‐Head comparison of consensus‐recommended platelet function tests to assess P2Y12 Inhibition : insights for multi‐center trials
(MDPI, 2020)The vasodilator‐associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted ... -
Hotspot or blind spot? Historical perspectives on surveillance and response to epidemics in the Central African Republic
(Springer, 2020-02-12)Objectives The Central African Republic (CAR), a site of recurrent disease emergence, developed a noteworthy epidemiological surveillance system from the colonial period, but its health measures have remained among the world’s lowest. To understand ... -
Hydration forces at solid and fluid biointerfaces
(American Vacuum Society, 2016-01)We review the different molecular mechanisms giving rise to the repulsive hydration force between biologically relevant surfaces such as lipid bilayers and bio-ceramics. As we will show, the hydration force manifests itself in very different and ... -
Impact of discretization of the timeline for longitudinal causal inference methods
(Wiley, 2020-09-01)In longitudinal settings, causal inference methods usually rely on a discretization of the patient timeline that may not reflect the underlying data generation process. This paper investigates the estimation of causal parameters under discretized ... -
Implications of the antiplatelet therapy gap left with discontinuation of prasugrel in Canada
(Elsevier, 2020-12-16)Background The current Canadian Cardiovascular Society antiplatelet therapy guidelines recommend the use of ticagrelor or prasugrel over clopidogrel as first-line platelet P2Y12 receptor antagonists for treatment of moderate- to high-risk acute coronary ... -
(In)stability of ligands at the surface of inorganic nanoparticles : a forgotten question in nanomedicine?
(Elsevier, 2022-06-14)Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine. Various core materials and shapes are explored, but they all display a common hybrid structure, with organic ligands on their surface. These ligands play a key role ... -
Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery
(Taylor & Francis, 2018-11-13)Inflammatory mechanisms are activated, and thrombotic complications occur during the initial months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet activation and platelet–leukocyte interactions after CABG are ... -
Insiders, smart drugs et pharmaceuticalisation : éléments pour une typologie de la nouvelle déviance conformiste
(Département de sociologie de l’Université du Québec à Montréal & Athéna éditions, 2016)La multiplication des usagers et usagères des smart drugs sur les campus universitaires, des go-pills dans l’armée ou encore des coast-to-coast chez les camionneurs de longue distance invite à revisiter la légitimité croissante des « usages adaptatifs ... -
Interaction forces between pegylated star-shaped polymers at mica surfaces
(American Chemical Society, 2017-08-03)We present a study focused on characterizing the interaction forces between mica surfaces across solutions containing star-shaped polymers with cationic ends. Using the Surface Forces Apparatus, we show that the interaction forces in pure water between ... -
Interfacial forces across ionic liquid solutions : effect of ion concentration and water domains
(American Chemical Society, 2019-07-23)Using the surface force apparatus (SFA), the interaction forces between mica surfaces across ionic liquid (IL) solutions are studied. The IL solution, 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide in propylene carbonate solvent, is used ... -
Intermolecular interactions between Bottlebrush Polymers boost the protection of surfaces against frictional wear
(ACS Publications, 2018-05-30)Polymers exhibiting the bottlebrush (BB) architecture have excellent lubricating properties. However, to motivate their use in real life systems, they must also protect surfaces against frictional damage. In this article, we synthesized a library of ... -
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
(American Chemical Society, 2018-11-21)We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial fluid is composed of sodium hyaluronate (HA) and a bottle-brush ... -
Mechanistic insights into the directed assembly of hydrogel blocks mediated by polyelectrolytes or microgels
(2017-04-18)In this study, we report the directed assembly of hydrogel blocks mediated by electrostatic interactions. We compared two different assembly mechanisms, one mediated by microgel particles and another mediated by direct interaction between ... -
A meta-analysis of the effect of paper versus digital reading on reading comprehension in health professional education
(American Association of Colleges of Pharmacy, 2021-12-29)Objective. Despite a rise in the use of digital education in health professional education (HPE), little is known about the comparative effectiveness of paper-based reading and its digital alternative on reading comprehension. The objectives of this ... -
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patient data meta-analysis
(SAGE, 2021)Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine can be improved by identifying ... -
Monoclonal antibodies and immunotherapy : theory and applications
(2023-06-27)The primary goal of this course is to provide the theoretical background necessary to better understand the mechanism of immunotherapy and in particular the mode of action of monoclonal antibodies currently available in immunotherapy. -
Monoclonal antibodies and immunotherapy : theory and applications
(2024)This document is an update of a previous one published on the Papyrus site of the University of Montreal in 2023. It takes into account new therapeutic targets as well as monoclonal antibodies approved last year by the FDA. This update consists of ... -
A multi-modal miniature surface forces apparatus (µSFA) for interfacial science measurements
(American Chemical Society, 2019-07-30)Advances in the research of intermolecular and surface interactions result from the development of new and improved measurement techniques and combinations of existing techniques. Here, we present a new miniature version of the Surface Force Apparatus ... -
Nanonization of megestrol acetate by laser fragmentation in aqueous milieu
(2011-02-10)Nanonization is a simple and effective method to improve dissolution rate and oral bioavailability of drugs with poor water solubility. There is growing interest to downscale the nanocrystal production to enable early preclinical evaluation of new ... -
Nanoparticle heterogeneity : an emerging structural parameter 2 influencing particle fate in biological media?
(Royal Society of Chemistry, 2018-11-27)Drug nanocarriers’ surface chemistry is often presumed to be uniform. For instance, the polymer surface coverage and distribution of ligands on nanoparticles are described with averaged values obtained from quantification techniques based on particle ... -
Nanoparticle shell structural cues drive in vitro transport properties, tissue distribution and brain accessibility in Zebrafish
(Elsevier, 2021-08-24)Zwitterion polymers with strong antifouling properties have been suggested as the prime alternative to polyethylene glycol (PEG) for drug nanocarriers surface coating. It is believed that PEG coating shortcomings, such as immune responses and incomplete ... -
Non-covalent formulation of active principles with dendrimers: current state-of-the-art and prospects for further development
(Elsevier, 2017-09-06)During the last three decades, dendrimers, nano-sized highly-branched fractal-like symmetrical macromolecules, have been intensively studied as promising candidates for application as drug-delivery carriers. Among other important characteristics arising ... -
Nonspecific interactions in biomedical applications
(Elsevier, 2019-12-20)Nonspecific interactions play a major role in the microscale functioning of biological units. Exploiting these interactions in design and application of biomedical systems has been beneficial in different branches of biomedicine. In this review, recently ... -
Phytoglycogen nanoparticles : nature-derived superlubricants
(American Chemical Society, 2021-05-07)Phytoglycogen nanoparticles (PhG NPs), a single-molecule highly branched polysaccharide, exhibit excellent water retention, due to the abundance of close-packed hydroxyl groups forming hydrogen bonds with water. Here we report lubrication properties ... -
Plasmon-free polymeric nanowrinkled substrates for surface-enhanced raman spectroscopy of two-dimensional materials
(American Chemical Society, 2020-12-21)We report plasmon-free polymeric nanowrinkled substrates for surface-enhanced Raman spectroscopy (SERS). Our simple, rapid, and cost-effective fabrication method involves depositing a poly(ethylene glycol)diacrylate (PEGDA) prepolymer solution droplet ... -
Platelet function in aging
(Frontiers Media, 2019-08-07)Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that ... -
Platelet function tests
(Thieme Publishing, 2016-04)Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate ... -
Platelet quiescence in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery
(Wiley, 2021)BACKGROUND: The optimal antiplatelet strategy for patients with acute coronary syndromes who require coronary artery bypass surgery remains unclear. While a more potent antiplatelet regimen will predispose to perioperative bleeding, it is hypothesized ... -
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
(Frontiers Media, 2020-11-25)Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, it has been suggested that ... -
Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model
(MDPI, 2020-09-14)Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on ... -
Preparedness for the next epidemic : health and political issues of an emerging paradigm
(Taylor & Francis, 2018-03-08)‘Preparing for the next epidemic’ has been a recurrent theme in global health in recent years. Starting with SARS, by way of the Avian influenza, and intensifying after the 2013–2016 Ebola outbreak, the urgency of preparing for the next health ... -
Prescription channeling of COX-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs: a population-based case–control study
(2005)This pharmacoepidemiologic study was conducted to determine whether risk factors for upper gastrointestinal bleeding influenced the prescription of cyclo-oxygenase (COX)-2 inhibitors and traditional nonselective nonsteroidal anti-inflammatory drugs ... -
Quantification of peptides in human synovial fluid using liquid chromatography–tandem mass spectrometry
(Elsevier, 2018-04-06)A method to explore the stability of two anti-inflammatory peptides in human synovial fluid (HSF) has been developed and validated using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The two peptides are BQ123 Cyclo(-D-Trp-D-A ... -
A quantitative UHPLC-MS/MS method for the growth hormone-releasing peptide-6 determination in complex biological matrices and transdermal formulations
A quantitative UPLC-MS/MS method for the growth hormone-releasing peptide-6 determination in complex biological matrices and transdermal formulations
(Elsevier, 2021-05-26)Growth hormone-releasing peptide-6 (GHRP-6) is part of a group of small synthetic peptides with potent GH-releasing activity that have gained attention in the last two decades by virtue of their cyto- and cardioprotective effects. Despite numerous ... -
A randomized double-blind feasibility study comparing cetirizine and diphenhydramine in the prevention of paclitaxel-associated infusion-related reactions : the PREMED-F1 study
(Springer, 2022-01-08)Purpose. Cetirizine is a less sedative alternative to diphenhydramine for the prevention of infusion-related reactions (IRR) to paclitaxel. However, its use remains controversial. In this study, we assessed feasibility for a future definitive ... -
Rationing hepatitis C treatment in the context of austerity policies in France and Cameroon : a transnational perspective on thepharmaceuticalization of healthcare systems
(Elsevier, 2017-03-28)New powerful drugs against hepatitis C can cure the disease, but they are not widely distributed because their exorbitant prices are destabilizing healthcare systems in both African and European countries. This article takes access to hepatitis C ... -
Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis
(Elsevier, 2021-01-12)Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in older populations and is expected to be the most dominant cause of disability in the world population by 2030. The progression of OA is controlled by a ... -
The relational dimensions of pharmaceutical care : experience from caring for HIV-infected asylum seekers in Montréal
(Elsevier, 2019-09-03)By describing the experience from dispensing antiretroviral drugs to asylum seekers infected with HIV in Montreal we argue for the relational dimensions of pharmaceutical care. Between 2010 and 2016, the Government of Canada changed the medical coverage ... -
Release kinetics from nano-inclusion-based and affinity-based hydrogels: A comparative study
(Elsevier, 2017-06-15)In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), nanogels made of ... -
Resistance and mutations of non-specificity in the field of anxietydepressive disorders in Canadian medical journals, 1950-1990
(Elsevier, 2014-12-03)Pharmaceuticalisation is a complex phenomenon, co-constitutive of what scholars identify as a pharmaceutical regime, comprised of networks of actors, institutions and artefacts as well as cognitive structures that underlie the production, promotion ... -
Short-sequence superadhesive peptides with topologically en-hanced cation-π interactions
(American Chemical Society, 2021-06-03)In this study, using the surface force apparatus, we report engineered peptides with short sequences of phenylalanine (F) and lysine (K) amino acids capable of forming the most efficient cation−π interactions reported for underwater adhesive systems ... -
Signaling of angiotensin II-induced vascular protein synthesis in conduit and resistance arteries in vivo
(2004)BACKGROUND:From in vitro studies, it has become clear that several signaling cascades are involved in angiotensin II-induced cellular hypertrophy. The aim of the present study was to determine some of the signaling pathways mediating angiotensin II ... -
Sonochemical synthesis of porous gold nano- and micro-particles in a Rosette cell for drug delivery applications
Sonochemical synthesis of porous gold nano- and microparticles in a Rosette cell
(Elsevier, 2021-09-05)We report the synthesis of gold nano- and micro-particles that relies on α-D-glucose (C6H12O6) as the reducer and stabilizer in a Rosette cell under 20 kHz ultrasound irradiation. The chemical and physical effects of ultrasonic irradiation on the ... -
Start small : how nanomedicine could alleviate the burden of rare CNS Diseases
(MDPI, 2021-01-30)The complexity and organization of the central nervous system (CNS) is widely modulated by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier (BCSFB), which both act as biochemical, dynamic obstacles impeding any ... -
Study of the bioaccumulation of tinzaparin in renally impaired patients when given at prophylactic doses : The STRIP study
Prophylactic tinzaparin in severe renal disease
(Elsevier, 2018-12-02) -
Subtle and unexpected role of PEG in tuning the penetration mechanisms of PLA-based nano-formulations into intact and impaired skin
(Elsevier, 2019-02-27)We present a systematic study of the role of poly(ethylene glycol) (PEG) content in NPs on drug skin absorption. Cholecalciferol-loaded NPs of 100 nm of diameter were prepared by flash nanoprecipitation from PLA-b-PEG copolymers of various PEG lengths. ... -
Superlubricity of zwitterionic bottlebrush polymers in the presence of multivalent ions
(American Chemical Society, 2020-08-13)In this study, we report lubrication properties of physisorbed zwitterionic bottlebrush polymers in the presence of multivalent ions using the surface force apparatus. Unlike polyelectrolyte brushes, the lubrication properties of which diminish drastically ... -
Superswelling microneedle arrays for dermal interstitial fluid (prote) omics
(Wiley, 2021-08-16)The noninvasive sampling of dermal interstitial fluid (ISF) for the monitoring of clinical biomarkers is a greatly appealing area of research. The identification of molecular biomarkers in biological fluids has been accelerated with -omics analyses but ... -
Synergy between zwitterionic polymers and hyaluronic acid enhances antifouling performance
(American Chemical Society, 2019-09-03)Challenges associated with nonspecific adsorption of proteins on sensor surfaces have steered the development of novel antifouling materials and strategies. Inspired by human synovial fluid composition and structure, we designed synergistic antifouling ... -
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
(Frontiers media, 2021-02-11)Platelets and neurons share many similarities including comparable secretory granule types with homologous calcium-dependent secretory mechanisms as well as internalization, sequestration and secretion of many neurotransmitters. Thus, platelets present ... -
A tutorial on dealing with time‐varying eligibility for treatment: Comparing the risk of major bleeding with direct‐acting oral anticoagulants vs warfarin
(Wiley, 2020-08-18)In this tutorial, we focus on the problem of how to define and estimate treatment effects when some patients develop a contraindication and are thus ineligible to receive a treatment of interest during follow-up. We first describe the concept of ... -
Tyrosine-based rivastigmine-loaded organogels in the treatmant of Alzheimer's disease
(2010-08)Organogels can be prepared by immobilizing an organic phase into a threedimensional network coming from the self-assembly of a low molecular weight gelator molecule. In this work, an injectable subcutaneous organogel system based on safflower oil and ... -
Understanding and diagnosing the potential for bias when using machine learning methods with doubly robust causal estimators
(SAGE, 2018-05-02)Data-adaptive methods have been proposed to estimate nuisance parameters when using doubly robust semiparametric methods for estimating marginal causal effects. However, in the presence of near practical positivity violations, these methods can produce ... -
Unified scaling of the structure and loading of nanoparticles formed via diffusion-limited coalescence
(American Chemical Society, 2018-04-30)The present study establishes the scaling laws describing the structure of spherical nanoparticles formed by diffusion-limited coalescence. We produced drug-loaded nanoparticles from a poly(ethylene glycol)-poly(d,l-lactic acid) diblock polymer (PEG-b-PLA) ...
