Browsing Faculté de pharmacie – Travaux et publications by Title
Now showing items 17-36 of 95
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Causal inference with multiple concurrent medications: a comparison of methods and an application in multidrug-resistant tuberculosis
(SAGE, 2018-10-31)This paper investigates different approaches for causal estimation under multiple concurrent medications. Our parameter of interest is the marginal mean counterfactual outcome under different combinations of medications. We explore parametric and ... -
Ce qu'expérienter fait faire
(Presses de l'Université du Québec, 2019) -
Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly
(Elsevier, 2019-08-29)We present chitosan hydrogel microfluidic devices with self-assembled complex microcapillary patterns, conveniently formed by a diffusion-reaction process. These patterns in chitosan hydrogels are formed by a single-step procedure involving diffusion ... -
Cholestérol, statines et prévention : apogée et chute de médicaments miracles
(Presses de l'Université du Québec, 2016) -
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults
(Frontiers Media, 2022-02-21)The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ... -
Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
Thrombocytopenia in acute coronary syndromes
(Taylor & Francis, 2018-10-22)Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence on the clinical importance of ... -
Coiled-coil affinity-based system for the controlled release of biofunctionalized gold nanoparticles from alginate hydrogels
(American Chemical Society, 2019-04-05)Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled coil affinity pair to mediate the release of gold nanoparticles (NPs) ... -
Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function : communication from the ISTH SSC Subcommittee on Platelet Physiology
(Wiley, 2021-09-12)Flow cytometry is increasingly used in the study of platelets in inherited and acquired disorders of platelet number and function. However, wide variation exists in specific reagents, methods, and equipment used, making interpretation and comparison ... -
Current and novel antiplatelet therapies for the treatment of cardiovascular diseases
(MDPI, 2021-12-03)Over the last decades, antiplatelet agents, mainly aspirin and P2Y12 receptor antagonists, have significantly reduced morbidity and mortality associated with arterial thrombosis. Their pharmacological characteristics, including pharmacokinetic/pharmacodynamics ... -
Data-adaptive longitudinal model selection in causal inference with collaborative targeted minimum loss-based estimation
(Wiley, 2019)Causal inference methods have been developed for longitudinal observationalstudy designs where confounding is thought to occur over time. In particular,one may estimate and contrast the population mean counterfactual outcomeunder specific exposure ... -
De la mesure au sens de la mesure : l’économie scripturaire du sida et de son traitement en République centrafricaine (RCA)
(Société d'Anthropologie des Connaissances, 2016-06-30)Pour donner sens à la mesure, il faut la rapporter à un système de valeurs qui en permet l’évaluation et le jugement. Voilà le parti pris théorique qui sous-tend cet article consacré aux pratiques d’écriture de la lutte contre le sida à partir d’une ... -
Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion
(American Chemical Society, 2022-12-14)Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply penetrating into dense tissues of the CNS could potentially transform the management of neurological diseases. In the present study, we investigated the interaction of ... -
Differences in platelet-rich plasma composition influence bone healing
(Wiley, 2021)Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and ... -
Dose-dependent pharmacokinetics of ropivacaine in anesthetized rabbits : absence of changes in protein binding
(Annex Publishers, 2019-04-25)Objective: The primary objectives of this study were to investigate the in vivo pharmacokinetics and in vitro plasma protein binding of ropivacaine at the concentration range observed after intravenous administration of different doses in anesthetized ... -
Drug-loaded nanocarriers : passive targeting and crossing of biological barriers
(2012-12)Poor bioavailability and poor pharmacokinetic characteristics are some of the leading causes of drug development failure. Therefore, poorly-soluble drugs, fragile proteins or nucleic acid products may benefit from their encapsulation in nanosized ... -
Effect of polymer architecture on Curcumin 1 encapsulation and release from PEGylated polymer nanoparticles: toward a drug delivery nano-platform to the CNS
(2015-10-01)We developed a nanoparticles (NPs) library from poly(ethylene glycol)–poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative ... -
Effect of Polymer Architecture on the Structural and Biophysical Properties of PEG-PLA Nanoparticles
(2015-05-01)Polymers made of poly(ethylene glycol) chains grafted to poly(lactic acid) chains (PEG-g-PLA) were used to produce stealth drug nanocarriers. A library of comb-like PEG-g-PLA polymers with different PEG grafting densities was prepared in order to obtain ... -
Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
(Elsevier, 2018-10-11)We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ... -
Electrostatic screening length in “soft” electrolyte solutions
(American Chemical Society, 2019-07-30)Using the Surface Forces Apparatus on solutions of polymeric ions, the effect of specific ion–ion correlations is evaluated on the characteristic decay length, λ, of screened electrostatic interactions between charged surfaces. Electrolyte solutions ... -
Estimating treatment importance in multidrug-resistant tuberculosis using Targeted Learning : an observational individual patient data network meta-analysis
Estimating MDR-TB treatment importance using TMLE
(Wiley, 2019)Persons with multidrug‐resistant tuberculosis (MDR‐TB) have a disease resulting from a strain of tuberculosis (TB) that does not respond to at least isoniazid and rifampicin, the two most effective anti‐TB drugs. MDR‐TB is always treated with multiple ...