Now showing items 1-20 of 25

  • Aging and language : maintenance of morphological representations in older adults 

    Royle, Phaedra; Steinhauer, Karsten; Dessureault, Émie; Herbay, Alexandre C.; Brambati, Simona Maria (Frontiers media, 2019-05-15)
    Studies employing primed lexical decision tasks have revealed morphological facilitation effects in children and young adults. It is unknown if this effect is preserved or diminished in older adults. In fact, only few studies have investigated ...
  • Anatomical correlates of early mutism in progressive nonfluent aphasia 

    Gorno-Tempini, Maria Luisa; Ogar, Jennifer M.; Brambati, Simona Maria; Wang, P.; Jeong, Je Hoon; Rankin, Katherine P.; Dronkers, Nina; Miller, Bruce L. (American Academy of Neurology, 2006)
    Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease. Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy. In PNFA with early mutism, volume ...
  • The anatomy of category-specific object naming in neurodegenerative diseases 

    Brambati, Simona Maria; Myers, D.; Wilson, A.; Rankin, Katherine P.; Allison, Stephen C.; Rosen, Howard J.; Miller, Bruce L.; Gorno-Tempini, Maria Luisa (Massachusetts Institute of Technology Press, 2006)
    Neuropsychological studies suggest that knowledge about living and nonliving objects is processed in separate brain regions. However, lesion and functional neuroimaging studies have implicated different areas. To address this issue, we used voxel-based ...
  • Atrophy, metabolism and cognition in posterior cortical atrophy spectrum based on AD CSF biomarkers 

    Montembeault, Maxime; Brambati, Simona Maria; Lamari, Foudil; Michon, Agnès; Samri, Dalila; Epelbaum, Stéphane; Lacomblez, Lucette; Lehéricy, Stéphane; Habert, Marie-Odile; Dubois, Bruno; Kas, Aurélie; Migliaccio, Raffaella (Elsevier, 2018-10-10)
    Introduction In vivo clinical, anatomical and metabolic differences between posterior cortical atrophy (PCA) patients presenting with different Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers profiles are still unknown. Methods Twenty-seven ...
  • The challenge of mapping the human connectome based on diffusion tractography 

    Maier-Hein, Klaus H.; Boré, Arnaud; Pinsard, Basile; Bedetti, Christophe; Desrosiers, Mathieu; Brambati, Simona Maria; Doyon, Julien; Descoteaux, Maxime (Nature research, 2017-11-07)
    Tractography based on non-invasive diffusion imaging is central to the study of human brain connectivity. To date, the approach has not been systematically validated in ground truth studies. Based on a simulated human brain data set with ground truth ...
  • Clinical, anatomical and pathological features in the three variants of primary progressive aphasia : a review 

    Montembeault, Maxime; Brambati, Simona Maria; Gorno-Tempini, Maria Luisa; Migliaccio, Raffaella (Frontiers media, 2018-08-21)
    Primary progressive aphasias (PPA) are neurodegenerative diseases clinically characterized by an early and relatively isolated language impairment. Three main clinical variants, namely the nonfluent/agrammatic variant (nfvPPA), the semantic variant ...
  • Comprehension of concrete and abstract words in semantic variant primary progressive aphasia and Alzheimer’s disease: a behavioral and neuroimaging study 

    Joubert, Sven; Vallet, Guillaume; Montembeault, Maxime; Boukadi, Mariem; Wilson, Maximiliano A.; Laforce, Robert Jr.; Rouleau, Isabelle; Brambati, Simona Maria (2017-04-20)
    The aim of this study was to investigate the comprehension of concrete, abstract and abstract emotional words in semantic variant primary progressive aphasia (svPPA), Alzheimer’s disease (AD), and healthy elderly adults (HE) Three groups of participants ...
  • Connected speech features from picture description in Alzheimer's disease: a systematic review 

    Slegers, Antoine; Filiou, Renée-Pier; Montembeault, Maxime; Brambati, Simona Maria (IOS Press, 2018-08-21)
    The language changes that occur over the course of Alzheimer’s disease (AD) can impact communication abilities and have profound functional consequences. Picture description tasks can be used to approximate everyday communication abilities of AD patients. ...
  • Differential involvement of the anterior temporal lobes in famous people semantics 

    Chedid, Georges; Wilson, Maximiliano A.; Provost, Jean-Sébastien; Joubert, Sven; Rouleau, Isabelle; Brambati, Simona Maria (Frontiers media, 2016-08-30)
    The ability to recognize a famous person occurs through semantic memory. Previous neuroimaging studies have shown that the anterior temporal lobes (ATLs) are involved in the recognition of famous people. However, it is still a matter of debate ...
  • Evidence of white matter changes on diffusion tensor imaging in frontotemporal dementia 

    Borroni, Barbara; Brambati, Simona Maria; Agosti, Chiara; Gipponi, Stefano; Bellelli, Giuseppe; Gasparotti, Roberto; Garibotto, Valentina; Di Luca, Monica; Scifo, Paola; Perani, Daniela; Padovani, Alessandro (American Medical Association, 2007)
    BACKGROUND: Two major clinical variants of frontotemporal dementia (FTD) have been described: frontal variant (fvFTD) and temporal variant (tvFTD). OBJECTIVE: To analyze white matter (WM) and gray matter (GM) tissue organization in patients with ...
  • Functional changes in the cortical semantic network in amnestic mild cognitive impairment 

    Pineault, Jessica; Jolicoeur, Pierre; Grimault, Stephan; Bermudez, Patrick; Brambati, Simona Maria; Lacombe, Jacinthe; Villalpando, Juan Manuel; Kergoat, Marie-Jeanne (American Psychological Association, 2018-05)
    Semantic memory impairment has been documented in older individuals with amnestic Mild cognitive impairment (aMCI), who are at risk of developing Alzheimer’s disease (AD), yet little is known about the neural basis of this breakdown. The main objective ...
  • The logopenic/phonological variant of primary progressive aphasia 

    Gorno-Tempini, Maria Luisa; Brambati, Simona Maria; Ginex, Valeria; Ogar, Jennifer M.; Dronkers, Nina; Marcone, Alessandra; Perani, Daniela; Garibotto, Valentina; Cappa, Stefano F.; Miller, Bruce L. (American Academy of Neurology, 2008)
    Objective: Primary progressive aphasia (PPA) is characterized by isolated decline in language functions. Semantic dementia and progressive nonfluent aphasia are accepted PPA variants. A “logopenic” variant (LPA) has also been proposed, but its cognitive ...
  • Longitudinal gray matter contraction in three variants of primary progressive aphasia : a tensor-based morphometry study 

    Brambati, Simona Maria; Amici, Serena; Racine, Caroline A.; Neuhaus, John; Miller, Zachary; Ogar, Jennifer M.; Dronkers, Nina; Miller, Bruce L.; Rosen, Howard; Gorno-Tempini, Maria Luisa (Elsevier, 2015-01-22)
    The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), ...
  • A MEG study of the neural substrates of semantic processing in semantic variant primary progressive aphasia 

    Pineault, Jessica; Jolicoeur, Pierre; Grimault, Stephan; Lacombe, Jacinthe; Brambati, Simona Maria; Bier, Nathalie; Chayer, Céline; Joubert, Sven (Taylor & Francis, 2019-07-01)
    Despite a well-documented pattern of semantic memory (SM) impairment, the patterns of brain activation during semantic processing in svPPA still remain poorly understood. The current study aimed to investigate the neural substrates of residual semantic ...
  • Music recognition in frontotemporal lobar degeneration and Alzheimer disease 

    Johnson, Julene K.; Chang, Chiung-Chih; Brambati, Simona Maria; Migliaccio, Raffaella; Gorno-Tempini, Maria Luisa; Miller, Bruce L.; Janata, Petr (Lippincott, Williams & Wilkins, 2011-06)
    Objective—To compare music recognition in patients with frontotemporal dementia, semantic dementia, Alzheimer disease, and controls and to evaluate the relationship between music recognition and brain volume. Background—Recognition of familiar music ...
  • The neural correlates of verbal and nonverbal semantic processing deficits in neurodegenerative disease 

    Butler, Christopher R.; Brambati, Simona Maria; Miller, Bruce L.; Gorno-Tempini, Maria-Luisa (Lippincott, Williams & Wilkins, 2009)
    Objective—To investigate the neural correlates of verbal and non-verbal semantic processing in neurodegenerative disease. Background—Semantic memory is often impaired in neurodegenerative disease. Neuropsychological and functional neuroimaging studies ...
  • Norms of concept familiarity and emotional valence for 3,596 French nouns and their contribution in lexical decision 

    Chedid, Georges; Wilson, Maximiliano A.; Bedetti, Christophe; Rey, Amandine E.; Vallet, Guillaume; Brambati, Simona Maria (Springer, 2018-08-20)
    In the last decade, research has shown that word processing is influenced by the lexical and semantic features of words. However, norms for a crucial semantic variable-that is, conceptual familiarity-have not been available for a sizeable French database. ...
  • Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI 

    Jubault, Thomas; Brambati, Simona Maria; Degroot, Clotilde; Kullmann, Benoit; Strafella, Antonio P.; Lafontaine, Anne-Louise; Chouinard, Sylvain; Monchi, Oury (Public Library of Science, 2009-12-10)
    Idiopathic Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the dysfunction of dopaminergic dependent cortico-basal ganglia loops and diagnosed on the basis of motor symptoms (tremors and/or rigidity and bradykinesia). ...
  • Regional reductions of gray matter volume in familial dyslexia 

    Brambati, Simona Maria; Termine, Cristiano; Ruffino, Milena; Stella, Giacomo; De Fazio, Francesco; Cappa, Stefano F.; Perani, Daniela (American Academy of Neurology, 2004)
    An in vivo anatomic study of gray matter volume was performed in a group of familial dyslexic individuals, using an optimized method of voxel-based morphometry. Focal abnormalities in gray matter volume were observed bilaterally in the planum temporale, ...
  • The role of the left anterior temporal lobe for unpredictable and complex mappings in word reading 

    Joyal, Marilyne; Brambati, Simona Maria; Laforce, Robert Jr.; Montembeault, Maxime; Boukadi, Mariem; Rouleau, Isabelle; Macoir, Joël; Joubert, Sven; Fecteau, Shirley; Wilson, Maximiliano A. (Frontiers media, 2017-04)
    The anterior temporal lobes (ATLs) have been consistently associated with semantic processing which, in turn, has a key role in reading aloud single words. This study aimed to investigate (1) the reading abilities in patients with the semantic variant ...