Browsing Faculté de pharmacie – Travaux et publications by Title
Now showing items 1-55 of 95
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2D, 3D and 4D active compound delivery in tissue engineering and regenerative medicine
(2015-07-01)Recent advances in tissue engineering and regenerative medicine have shown that controlling cells microenvironment during growth is a key element to the development of successful therapeutic system. To achieve such control, researchers have first ... -
Acetylcholinesterase inhibitors and risk of bleeding and acute ischemic events in non-hypertensive Alzheimer’s patients
(2021-08-20)Introduction: Acetylcholinesterase inhibitors (AChEIs) are commonly used to treat mild to moderate cases of Alzheimer disease (AD). To the best of our knowledge, there has been no study estimating the risk of bleeding and cardiovascular events in ... -
Advances in platelet function testing—light transmission aggregometry and beyond
(MDPI, 2020-08-13)Platelet function testing is essential for the diagnosis of hemostasis disorders. While there are many methods used to test platelet function for research purposes, standardization is often lacking, limiting their use in clinical practice. Light ... -
Anticorps monoclonaux et immunothérapie : théorie et applications
(2023-06-27)Le but premier de ce cours est de fournir les bases théoriques nécessaires pour mieux comprendre les mécanismes de l’immunothérapie et en particulier le mode d’action des anticorps monoclonaux actuellement disponibles en immunothérapie. -
Anticorps monoclonaux et immunothérapie : théorie et applications
(2024)Ce document est une mise à jour d’un précédent publié sur le site Papyrus de l’Université de Montréal en 2023. Il tient compte des cibles thérapeutiques nouvelles ainsi que des anticorps monoclonaux agréés l’an dernier par la FDA. Cette mise à jour ... -
Antiplatelet therapy for atherothrombotic disease in 2022 : from population to patient-centered approaches
(Frontiers Media, 2022-01-28)Antiplatelet agents, with aspirin and P2Y12 receptor antagonists as major key molecules, are currently the cornerstone of pharmacological treatment of atherothrombotic events including a variety of cardio- and cerebro-vascular as well as peripheral ... -
Antiplatelet therapy in atherothrombotic diseases : similarities and differences across guidelines
(Frontiers media, 2022-04-27)Antiplatelet therapy, mainly consisting of aspirin and P2Y12 receptor antagonists, is the cornerstone of the pharmacological treatment and prevention of atherothrombotic diseases. Its use, especially in secondary cardiovascular prevention, has ... -
The application of target trials with longitudinal targeted maximum likelihood estimation to assess the effect of alcohol consumption in adolescence on depressive symptoms in adulthood
(Oxford University Press, 2023-12-07)Time-varying confounding is a common challenge for causal inference in observational studies with time-varying treatments, long follow-up periods, and participant dropout. Confounder adjustment using traditional approaches can also be limited by data ... -
Assessing cardiometabolic parameter monitoring in inpatients taking a second-generation antipsychotic : the CAMI-SGA study – a crosssectional study
(BMJ Publishing Group, 2022)Objectives This study aims to determine the proportion of initial cardiometabolic assessment and its predicting factors in adults with schizophrenia, bipolar disorder or other related diagnoses for whom a second-generation antipsychotic was prescribed ... -
Assessment of PEG on Polymeric Particles Surface, a Key Step in Drug Carrier Translation
(2014-07)Injectable drug nanocarriers have greatly benefited in their clinical development from the addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The most studied and used polymer for this purpose is poly(ethylene glycol), ... -
Aux frontières du médicament
(Presses de l’Université du Québec, 2016) -
Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
(American Chemical Society, 2018-01-29)Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block copolymers present certain advantages ... -
Bioinspired microstructures of chitosan hydrogel provide enhanced wear protection
(Royal Society of Chemistry, 2018-02-16)We describe the fabrication of physical chitosan hydrogels exhibiting a layered structure. This bilayered structure, as shown by SEM and confocal microscopy, is composed of a thin dense superficial zone (SZ), covering a deeper zone (DZ) containing ... -
Biomimetic bottle-brush polymer coatings for fabrication of ultra-low fouling surfaces
(Wiley, 2018-11-13)The increasing demand for long lasting antifouling surfaces has steered the development of accessible, novel, biocompatible and environmentally-friendly materials. Inspired by lubricin (LUB), a component of mammalian synovial fluid with excellent ... -
Brain-derived neurotrophic factor mitigates the association between platelet dysfunction and cognitive impairment
(Frontiers media, 2021-09-07)Background: Platelet hyperactivity is deleterious in coronary artery disease (CAD), requiring lifelong antiplatelet therapy, and is associated with worse cognitive outcomes. Upon activation, platelets release Brain-Derived Neurotrophic Factor (BDNF), ... -
The brain-derived neurotrophic factor prompts platelet aggregation and secretion
(American Society of Hematology, 2021-09-21)Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in neurons, and its release and signaling mechanisms have been extensively studied in the central nervous system. Large quantities of BDNF have been reported in ... -
Causal inference with multiple concurrent medications: a comparison of methods and an application in multidrug-resistant tuberculosis
(SAGE, 2018-10-31)This paper investigates different approaches for causal estimation under multiple concurrent medications. Our parameter of interest is the marginal mean counterfactual outcome under different combinations of medications. We explore parametric and ... -
Ce qu'expérienter fait faire
(Presses de l'Université du Québec, 2019) -
Chitosan hydrogel micro-bio-devices with complex capillary patterns via reactive-diffusive self-assembly
(Elsevier, 2019-08-29)We present chitosan hydrogel microfluidic devices with self-assembled complex microcapillary patterns, conveniently formed by a diffusion-reaction process. These patterns in chitosan hydrogels are formed by a single-step procedure involving diffusion ... -
Cholestérol, statines et prévention : apogée et chute de médicaments miracles
(Presses de l'Université du Québec, 2016) -
Clinical correlates identify ProBDNF and thrombo-inflammatory markers as key predictors of circulating p75NTR extracellular domain levels in older adults
(Frontiers Media, 2022-02-21)The p75NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75NTR has been reported in plasma, its levels being dysregulated in numerous neurological ... -
Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
Thrombocytopenia in acute coronary syndromes
(Taylor & Francis, 2018-10-22)Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence on the clinical importance of ... -
Coiled-coil affinity-based system for the controlled release of biofunctionalized gold nanoparticles from alginate hydrogels
(American Chemical Society, 2019-04-05)Affinity-based systems represent a promising solution to control the delivery of therapeutics using hydrogels. Here, we report a hybrid system that is based on the peptidic E/K coiled coil affinity pair to mediate the release of gold nanoparticles (NPs) ... -
Consensus recommendations on flow cytometry for the assessment of inherited and acquired disorders of platelet number and function : communication from the ISTH SSC Subcommittee on Platelet Physiology
(Wiley, 2021-09-12)Flow cytometry is increasingly used in the study of platelets in inherited and acquired disorders of platelet number and function. However, wide variation exists in specific reagents, methods, and equipment used, making interpretation and comparison ... -
Current and novel antiplatelet therapies for the treatment of cardiovascular diseases
(MDPI, 2021-12-03)Over the last decades, antiplatelet agents, mainly aspirin and P2Y12 receptor antagonists, have significantly reduced morbidity and mortality associated with arterial thrombosis. Their pharmacological characteristics, including pharmacokinetic/pharmacodynamics ... -
Data-adaptive longitudinal model selection in causal inference with collaborative targeted minimum loss-based estimation
(Wiley, 2019)Causal inference methods have been developed for longitudinal observationalstudy designs where confounding is thought to occur over time. In particular,one may estimate and contrast the population mean counterfactual outcomeunder specific exposure ... -
De la mesure au sens de la mesure : l’économie scripturaire du sida et de son traitement en République centrafricaine (RCA)
(Société d'Anthropologie des Connaissances, 2016-06-30)Pour donner sens à la mesure, il faut la rapporter à un système de valeurs qui en permet l’évaluation et le jugement. Voilà le parti pris théorique qui sous-tend cet article consacré aux pratiques d’écriture de la lutte contre le sida à partir d’une ... -
Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion
(American Chemical Society, 2022-12-14)Drug nanocarriers (NCs) capable of crossing the vascular endothelium and deeply penetrating into dense tissues of the CNS could potentially transform the management of neurological diseases. In the present study, we investigated the interaction of ... -
Differences in platelet-rich plasma composition influence bone healing
(Wiley, 2021)Aim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and ... -
Dose-dependent pharmacokinetics of ropivacaine in anesthetized rabbits : absence of changes in protein binding
(Annex Publishers, 2019-04-25)Objective: The primary objectives of this study were to investigate the in vivo pharmacokinetics and in vitro plasma protein binding of ropivacaine at the concentration range observed after intravenous administration of different doses in anesthetized ... -
Drug-loaded nanocarriers : passive targeting and crossing of biological barriers
(2012-12)Poor bioavailability and poor pharmacokinetic characteristics are some of the leading causes of drug development failure. Therefore, poorly-soluble drugs, fragile proteins or nucleic acid products may benefit from their encapsulation in nanosized ... -
Effect of polymer architecture on Curcumin 1 encapsulation and release from PEGylated polymer nanoparticles: toward a drug delivery nano-platform to the CNS
(2015-10-01)We developed a nanoparticles (NPs) library from poly(ethylene glycol)–poly lactic acid comb-like polymers with variable amount of PEG. Curcumin was encapsulated in the NPs with a view to develop a delivery platform to treat diseases involving oxidative ... -
Effect of Polymer Architecture on the Structural and Biophysical Properties of PEG-PLA Nanoparticles
(2015-05-01)Polymers made of poly(ethylene glycol) chains grafted to poly(lactic acid) chains (PEG-g-PLA) were used to produce stealth drug nanocarriers. A library of comb-like PEG-g-PLA polymers with different PEG grafting densities was prepared in order to obtain ... -
Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
(Elsevier, 2018-10-11)We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ... -
Electrostatic screening length in “soft” electrolyte solutions
(American Chemical Society, 2019-07-30)Using the Surface Forces Apparatus on solutions of polymeric ions, the effect of specific ion–ion correlations is evaluated on the characteristic decay length, λ, of screened electrostatic interactions between charged surfaces. Electrolyte solutions ... -
Estimating treatment importance in multidrug-resistant tuberculosis using Targeted Learning : an observational individual patient data network meta-analysis
Estimating MDR-TB treatment importance using TMLE
(Wiley, 2019)Persons with multidrug‐resistant tuberculosis (MDR‐TB) have a disease resulting from a strain of tuberculosis (TB) that does not respond to at least isoniazid and rifampicin, the two most effective anti‐TB drugs. MDR‐TB is always treated with multiple ... -
Factors associated with psychotropic drug use among community-dwelling older persons: A review of empirical studies
(2004)BACKGROUND:In the many descriptive studies on prescribed psychotropic drug use by community-dwelling older persons, several sociodemographic and other factors associated with drug use receive inconsistent support.METHOD:Empirical reports with data on ... -
Head‐to‐Head comparison of consensus‐recommended platelet function tests to assess P2Y12 Inhibition : insights for multi‐center trials
(MDPI, 2020)The vasodilator‐associated stimulated phosphoprotein (VASP) phosphorylation level is a highly specific method to assess P2Y12 receptor inhibition. Traditionally, VASP phosphorylation is analyzed by flow cytometry, which is laborious and restricted ... -
Hotspot or blind spot? Historical perspectives on surveillance and response to epidemics in the Central African Republic
(Springer, 2020-02-12)Objectives The Central African Republic (CAR), a site of recurrent disease emergence, developed a noteworthy epidemiological surveillance system from the colonial period, but its health measures have remained among the world’s lowest. To understand ... -
Hydration forces at solid and fluid biointerfaces
(American Vacuum Society, 2016-01)We review the different molecular mechanisms giving rise to the repulsive hydration force between biologically relevant surfaces such as lipid bilayers and bio-ceramics. As we will show, the hydration force manifests itself in very different and ... -
Impact of discretization of the timeline for longitudinal causal inference methods
(Wiley, 2020-09-01)In longitudinal settings, causal inference methods usually rely on a discretization of the patient timeline that may not reflect the underlying data generation process. This paper investigates the estimation of causal parameters under discretized ... -
Implications of the antiplatelet therapy gap left with discontinuation of prasugrel in Canada
(Elsevier, 2020-12-16)Background The current Canadian Cardiovascular Society antiplatelet therapy guidelines recommend the use of ticagrelor or prasugrel over clopidogrel as first-line platelet P2Y12 receptor antagonists for treatment of moderate- to high-risk acute coronary ... -
(In)stability of ligands at the surface of inorganic nanoparticles : a forgotten question in nanomedicine?
(Elsevier, 2022-06-14)Multiple inorganic nanoparticles (NPs) are currently being developed for nanomedicine. Various core materials and shapes are explored, but they all display a common hybrid structure, with organic ligands on their surface. These ligands play a key role ... -
Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery
(Taylor & Francis, 2018-11-13)Inflammatory mechanisms are activated, and thrombotic complications occur during the initial months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet activation and platelet–leukocyte interactions after CABG are ... -
Insiders, smart drugs et pharmaceuticalisation : éléments pour une typologie de la nouvelle déviance conformiste
(Département de sociologie de l’Université du Québec à Montréal & Athéna éditions, 2016)La multiplication des usagers et usagères des smart drugs sur les campus universitaires, des go-pills dans l’armée ou encore des coast-to-coast chez les camionneurs de longue distance invite à revisiter la légitimité croissante des « usages adaptatifs ... -
Interaction forces between pegylated star-shaped polymers at mica surfaces
(American Chemical Society, 2017-08-03)We present a study focused on characterizing the interaction forces between mica surfaces across solutions containing star-shaped polymers with cationic ends. Using the Surface Forces Apparatus, we show that the interaction forces in pure water between ... -
Interfacial forces across ionic liquid solutions : effect of ion concentration and water domains
(American Chemical Society, 2019-07-23)Using the surface force apparatus (SFA), the interaction forces between mica surfaces across ionic liquid (IL) solutions are studied. The IL solution, 1-hexyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide in propylene carbonate solvent, is used ... -
Intermolecular interactions between Bottlebrush Polymers boost the protection of surfaces against frictional wear
(ACS Publications, 2018-05-30)Polymers exhibiting the bottlebrush (BB) architecture have excellent lubricating properties. However, to motivate their use in real life systems, they must also protect surfaces against frictional damage. In this article, we synthesized a library of ... -
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
(American Chemical Society, 2018-11-21)We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial fluid is composed of sodium hyaluronate (HA) and a bottle-brush ... -
Mechanistic insights into the directed assembly of hydrogel blocks mediated by polyelectrolytes or microgels
(2017-04-18)In this study, we report the directed assembly of hydrogel blocks mediated by electrostatic interactions. We compared two different assembly mechanisms, one mediated by microgel particles and another mediated by direct interaction between ... -
A meta-analysis of the effect of paper versus digital reading on reading comprehension in health professional education
(American Association of Colleges of Pharmacy, 2021-12-29)Objective. Despite a rise in the use of digital education in health professional education (HPE), little is known about the comparative effectiveness of paper-based reading and its digital alternative on reading comprehension. The objectives of this ... -
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patient data meta-analysis
(SAGE, 2021)Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine can be improved by identifying ... -
Monoclonal antibodies and immunotherapy : theory and applications
(2023-06-27)The primary goal of this course is to provide the theoretical background necessary to better understand the mechanism of immunotherapy and in particular the mode of action of monoclonal antibodies currently available in immunotherapy. -
Monoclonal antibodies and immunotherapy : theory and applications
(2024)This document is an update of a previous one published on the Papyrus site of the University of Montreal in 2023. It takes into account new therapeutic targets as well as monoclonal antibodies approved last year by the FDA. This update consists of ... -
A multi-modal miniature surface forces apparatus (µSFA) for interfacial science measurements
(American Chemical Society, 2019-07-30)Advances in the research of intermolecular and surface interactions result from the development of new and improved measurement techniques and combinations of existing techniques. Here, we present a new miniature version of the Surface Force Apparatus ...