Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis
dc.contributor.author | Sauvageau, Anny | |
dc.contributor.author | Desjardins, Paul | |
dc.contributor.author | Lozeva, Violina | |
dc.contributor.author | Rose, Christopher | |
dc.contributor.author | Hazell, Alan S. | |
dc.contributor.author | Bouthillier, Alain | |
dc.contributor.author | Butterworth, Roger | |
dc.date.accessioned | 2013-04-23T18:46:08Z | |
dc.date.available | 2013-04-23T18:46:08Z | |
dc.date.issued | 2002 | |
dc.identifier.uri | http://hdl.handle.net/1866/9575 | |
dc.subject | Épilepsie temporale | en |
dc.subject | Hippocampe | en |
dc.subject | Hippocampus | en |
dc.subject | Peripheral-type benzodiazepine receptors | en |
dc.subject | Position emission tomography | en |
dc.subject | Récepteurs GABA-A | en |
dc.subject | Temporal lobe epilepsy | en |
dc.subject | Tomographie par émission de positons / tomodensitométrie | en |
dc.title | Increased expression of "peripheral-type" benzodiazepine receptors in human temporal lobe epilepsy: implications for PET imaging of hippocampal sclerosis | |
dc.type | Article | en |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Centre de recherche du CHUM | fr |
dc.identifier.doi | 10.1023/A:1014044128845 | |
dcterms.abstract | Increased binding sites for "peripheral-type" benzodiazepine receptor (PTBR) ligands have been described in a wide range of neurological disorders including both human and experimental epilepsy. This study was undertaken to assess PTBR expression in relation to the presence of hippocampal sclerosis in human temporal lobe epilepsy (TLE). For this purpose, hippocampal CA1 subfields were dissected from surgical samples from patients with therapy-refractive TLE with (n = 5) or without (n = 2) hippocampal sclerosis and from age-matched nonepileptic postmortem controls (n = 5). PTBR expression was assessed by immunohistochemistry and reverse-transcription polymerase chain reaction. Receptor sites were evaluated using an in vitro binding assay and the selective PTBR ligand [3H]PK11195. Epileptic patients with hippocampal sclerosis showed increases in PTBR binding sites, immunoreactivity, and mRNA expression compared to both nonsclerotic TLE patients and postmortem nonepileptic controls. Induction of PTBR expression and binding sites were directly correlated with the presence of hippocampal sclerosis and the accompanying reactive gliosis. | en |
dcterms.language | eng | en |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Metabolic brain disease | |
oaire.citationVolume | 17 | |
oaire.citationIssue | 1 | |
oaire.citationStartPage | 3 | |
oaire.citationEndPage | 11 |
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