Browsing Faculté de médecine – Travaux et publications by Title
Now showing items 1-20 of 603
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A 12-week open-label, multicenter study evaluating the safety and patient-reported efficacy of sodium oxybate in patients with narcolepsy and cataplexy
(Elsevier, 2015)Objective: This study aimed to evaluate safety and efficacy of sodium oxybate (SXB) titrated to effect. Methods: SXB-naive patients who had participated in a randomized SXB clinical trial and had not been titrated to adequate clinical effect were ... -
175 years of bilirubin testing : ready for point-of-care?
(Wiley, 2023-04-10)Bilirubin was first detected in blood in 1847 and since then has become one of the most widely used biomarkers for liver disease. Clinical routine bilirubin testing is performed at the hospital laboratory, and the gold standard colorimetric test is ... -
2021 ISHEN guidelines on animal models of hepatic encephalopathy
(Wiley, 2021-04-01)This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models of hepatic encephalopathy (HE). ... -
The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection
(American Association for the Advancement of Science, 2015-12-16)Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale ... -
3D Cohort Study : The Integrated Research Network in Perinatology of Quebec and Eastern Ontario
(Wiley, 2016)Background: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. Methods: Pregnant ... -
3D registration of MR and X-ray spine images using an articulated model
(2012-07)Présentation: Cet article a été publié dans le journal : Computerised medical imaging and graphics (CMIG). Le but de cet article est de recaler les vertèbres extraites à partir d’images RM avec des vertèbres extraites à partir d’images RX pour des ... -
The 3D-Transition study : objectives, methods, and implementation of an innovative planned missing data design
(Oxford University Press, 2021-05-12)The prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children’s early ... -
Abstracts of posters and platform sessions accepted for virtual presentation at the 2020 Annual Meeting of the Society for developmental and behavioral pediatrics. Pubertal development and adolescent alcohol use : a prospective study on the role of sensation seeking and impulsivity. Abstract 46
(Lippincott, Williams & Wilkins, 2021-02-01) -
L'accord de l'adjectif chez les enfants francophones avec un trouble spécifique du langage
Adjective concord in Young French-speakers with specific language impairment
La concordancia adjetival en franco hablantes con trastorno especifico del lenguaje(École d'orthophonie et d'audiologie, 2010)En dépit du fait que l’étude de la production du syntagme nominal puisse fournir des données riches sur les phénomènes d’accord et de concordance, cette structure demeure peu étudiée. L’étude rapportée ici décrit l’accord intra-nominal, - c’est-à-dire ... -
L’acquisition du genre quand il est déjà acquis : l’expérience d’enfants hispanophones apprenant le français
The acquisition of gender once it has already been mastered: The experience of Spanish-speaking children learning French
(Orthophonie et Audiologie Canada, 2015)This study tests the acquisition of French in Spanish-speaking children by documenting the acquisition of noun phrases in sequential bilingual (Spanish-French) children, compared to native French speakers, matched according to age or language development ... -
Acquisition of French adjectives in Quebec French as revealed by elicitation data
Acquisition of Quebec French adjectives as revealed by elicitation data
(Cambridge University Press, 2010)This study presents data from an elicitation study on French size and color adjectives in noun phrases (DPs), both early acquired structures. Thirty-two francophone children aged 3–5 years participated in the study. Adjectives were elicited using ... -
Active nuclear import and cytoplasmic retention of activation-induced deaminase
(2009)The enzyme activation-induced deaminase (AID) triggers antibody diversification in B cells by catalyzing deamination and consequently mutation of immunoglobulin genes. To minimize off-target deamination, AID is restrained by several regulatory mechanisms ... -
Activity monitor placed at the non-paretic ankle is accurate in measuring step counts during community walking in post-stroke individuals : a validation study
(Wiley, 2019-01-28)Background: Different environmental factors may affect the accuracy of step-count activity monitors (AM). However, the validationconditions for AM accuracy largely differ from ecological environments.Objectives: To assess and compare the accuracy of ... -
Acute carotid stenting in patients undergoing thrombectomy : a systematic review and meta-analysis
(BMJ Publishing Group, 2020-06-12)Background The benefit of acute carotid stenting compared with no acute stenting on clinical outcomes among patients with tandem lesions (TL) undergoing endovascular thrombectomy (EVT) remains unknown. Methods We conducted a a systematic review and ... -
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH
(2005)Hyperammonemia is a key factor in the pathogenesis of hepatic encephalopathy (HE) as well as other metabolic encephalopathies, such as those associated with inherited disorders of urea cycle enzymes and in Reye's syndrome. Acute HE results in increased ... -
Acute invariant NKT cell activation triggers an immune response that drives prominent changes in iron homeostasis
(Nature research, 2020-12-03)Iron homeostasis is an essential biological process that ensures the tissue distribution of iron for various cellular processes. As the major producer of hepcidin, the liver is central to the regulation of iron metabolism. The liver is also home to ... -
Addition of exogenous polypeptides on the mammalian reovirus outer capsid using reverse genetics
(Elsevier, 2012-02)Addition of exogenous peptide sequences on viral capsids is a powerful approach to study the process of viral infection or to retarget viruses toward defined cell types. Until recently, it was not possible to manipulate the genome of mammalian reovirus ... -
Adhesion and transcellular migration of neutrophils and B lymphocytes on fibroblasts
(2009)During tissue inflammation, infiltrated leukocytes may have physical contacts with fibroblasts. We observed that neutrophils and B lymphocytes adhered in a larger proportion than T cells on cultured fibroblasts. Microscopy showed that adhesion was also ... -
Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight
(Elsevier, 2016-08-23)Objective We previously demonstrated that the handle-region peptide, a prorenin/renin receptor [(P)RR] blocker, reduces body weight and fat mass and may improve insulin sensitivity in high-fat fed mice. We hypothesized that knocking out the adipose ... -
Advancing social inclusion of people with disabilities through awareness and training activities : a collaborative process between community partners and researchers
(Elsevier, 2021-05-23)Objective The main objectives were to 1) search and map current disability awareness and training activities in Quebec, Canada, 2) collectively reflect on these practices, and 3) develop a five-year strategic plan. Methods We used an integrated ...
