Now showing items 1-20 of 316

  • A 12-week open-label, multicenter study evaluating the safety and patient-reported efficacy of sodium oxybate in patients with narcolepsy and cataplexy 

    Mamelak, Mortimer; Swick, Todd; Emsellem, Helene; Montplaisir, Jacques-Yves; Lai, Chinglin; Black, Jed (Elsevier, 2015)
    Objective: This study aimed to evaluate safety and efficacy of sodium oxybate (SXB) titrated to effect. Methods: SXB-naive patients who had participated in a randomized SXB clinical trial and had not been titrated to adequate clinical effect were ...
  • The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection 

    Dieudé, Mélanie; Bell, Christina; Turgeon, Julie; Beillevaire, Déborah; Yang, Bing; Hamelin, Katia; Qi, Shijie; Pallet, Nicolas; Béland, Chanel; Dhahri, Wahiba; Cailhier, Jean-François; Rousseau, Matthieu; Duchez, Anne-Claire; Lévesque, Tania; Lau, Arthur; Rondeau, Christiane; Gingras, Diane; Muruve, Danie; Rivard, Alain; Cardinal, Héloïse; Perreault, Claude; Desjardins, Michel; Boilard, Éric; Thibault, Pierre; Hébert, Marie-Josée (American Association for the Advancement of Science, 2015-12-16)
    Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies, contribute to rejection in organ transplant recipients. However, mechanisms of immunization to apoptotic components remain largely uncharacterized. We used large-scale ...
  • 3D Cohort Study : The Integrated Research Network in Perinatology of Quebec and Eastern Ontario 

    Fraser, William; Shapiro, Gabriel; Dubois, Lise; Pasquier, Jean-Charles; Julien, Pierre; Bérard, Anick; Muckle, Gina; Trasler, Jacquetta; Tremblay, Richard Ernest; Abenhaim, Haim; Welt, Michel; Bissonnette, François; Bédard, Marie-Josée; Bujold, Emmanuel; Gagnon, Robert; Michaud, Jacques; Girard, Isabelle; Moutquin, Jean-Marie; Marc, Isabelle; Monnier, Patricia; Luo, Zhong-Cheng; 3D Study Group; Séguin, Jean; Audibert, François (Wiley, 2016)
    Background: The 3D Cohort Study (Design, Develop, Discover) was established to help bridge knowledge gaps about the links between various adverse exposures during pregnancy with birth outcomes and later health outcomes in children. Methods: Pregnant ...
  • 3D registration of MR and X-ray spine images using an articulated model 

    Harmouche, Rola; Cheriet, Farida; Labelle, Hubert; Dansereau, Jean (2012-07)
    Présentation: Cet article a été publié dans le journal : Computerised medical imaging and graphics (CMIG). Le but de cet article est de recaler les vertèbres extraites à partir d’images RM avec des vertèbres extraites à partir d’images RX pour des ...
  • L'accord de l'adjectif chez les enfants francophones avec un trouble spécifique du langage 

    Adjective concord in Young French-speakers with specific language impairment
    La concordancia adjetival en franco hablantes con trastorno especifico del lenguaje
    Royle, Phaedra; Toupin, Jacinthe; Bourguignon, Nicolas; Trudeau, Natacha; Valois, Daniel (École d'orthophonie et d'audiologie, 2010)
    En dépit du fait que l’étude de la production du syntagme nominal puisse fournir des données riches sur les phénomènes d’accord et de concordance, cette structure demeure peu étudiée. L’étude rapportée ici décrit l’accord intra-nominal, - c’est-à-dire ...
  • L’acquisition du genre quand il est déjà acquis : l’expérience d’enfants hispanophones apprenant le français 

    The acquisition of gender once it has already been mastered: The experience of Spanish-speaking children learning French
    Royle, Phaedra; Bergeron, Eve; Marquis, Alexandra (Orthophonie et Audiologie Canada, 2015)
    This study tests the acquisition of French in Spanish-speaking children by documenting the acquisition of noun phrases in sequential bilingual (Spanish-French) children, compared to native French speakers, matched according to age or language development ...
  • Acquisition of French adjectives in Quebec French as revealed by elicitation data 

    Acquisition of Quebec French adjectives as revealed by elicitation data
    Royle, Phaedra; Valois, Daniel (Cambridge University Press, 2010)
    This study presents data from an elicitation study on French size and color adjectives in noun phrases (DPs), both early acquired structures. Thirty-two francophone children aged 3–5 years participated in the study. Adjectives were elicited using ...
  • Active nuclear import and cytoplasmic retention of activation-induced deaminase 

    Patenaude, Anne-Marie; Orthwein, Alexandre; Hu, Yi; Campo, Vanina A.; Kavli, Bodil; Buschiazzo, Alejandro; Di Noia, Javier M. (2009)
    The enzyme activation-induced deaminase (AID) triggers antibody diversification in B cells by catalyzing deamination and consequently mutation of immunoglobulin genes. To minimize off-target deamination, AID is restrained by several regulatory mechanisms ...
  • Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH 

    Rose, Christopher; Wolfgang, Kresse; Kettenmann, Helmut (2005)
    Hyperammonemia is a key factor in the pathogenesis of hepatic encephalopathy (HE) as well as other metabolic encephalopathies, such as those associated with inherited disorders of urea cycle enzymes and in Reye's syndrome. Acute HE results in increased ...
  • Addition of exogenous polypeptides on the mammalian reovirus outer capsid using reverse genetics 

    Brochu-Lafontaine, Virginie; Lemay, Guy (Elsevier, 2012-02)
    Addition of exogenous peptide sequences on viral capsids is a powerful approach to study the process of viral infection or to retarget viruses toward defined cell types. Until recently, it was not possible to manipulate the genome of mammalian reovirus ...
  • Adhesion and transcellular migration of neutrophils and B lymphocytes on fibroblasts 

    Couture, Patrick; Paradis-Massie, Jérémie; Oualha, Nadia; Thibault, Gaétan (2009)
    During tissue inflammation, infiltrated leukocytes may have physical contacts with fibroblasts. We observed that neutrophils and B lymphocytes adhered in a larger proportion than T cells on cultured fibroblasts. Microscopy showed that adhesion was also ...
  • Algal Biofuels: Challenges and Opportunities 

    Leite, Gustavo Balduino; Abdelaziz, Ahmed E. M.; Hallenbeck, Patrick C. (Elsevier, 2013)
    Biodiesel production using microalgae is attractive in a number of respects. Here a number of pros and cons to using microalgae for biofuels production are reviewed. Algal cultivation can be carried out using non-arable land and non-potable water with ...
  • Altered sensory-weighting mechanisms is observed in adolescents with idiopathic scoliosis 

    Simoneau, Martin; Mercier, Pierre; Blouin, Jean; Allard, Paul; Teasdale, Normand (2006)
    BACKGROUND:Scoliosis is the most common type of spinal deformity. In North American children, adolescent idiopathic scoliosis (AIS) makes up about 90% of all cases of scoliosis. While its prevalence is about 2% to 3% in children aged between 10 to 16 ...
  • Alternative Time Representation in Dopamine Models 

    Rivest, François; Kalaska, John F.; Bengio, Yoshua (Springer Science + Business Media, 2009)
    Données originales publiées dans l'article: Rivest, F, Kalaska, J.F., Bengio, Y. (2009) Alternative time representation in dopamine models. Journal of Computational Neuroscience. doi:10.1007/s10827-009-0191-1
  • Amino acid substitutions in σ1 and μ1 outer capsid proteins are selected during mammalian reovirus adaptation to Vero cells 

    Jabre, Roland; Sandekian, Véronique; Lemay, Guy (Elsevier, 2013-09)
    Establishment of viral persistence in cell culture has previously led to the selection of mammalian reovirus mutants, although very few of those have been characterized in details. In the present study, reovirus was adapted to Vero cells that, in ...
  • Amino acids substitutions in σ1 and μ1 outer capsid proteins of a Vero cell-adapted mammalian orthoreovirus are required for optimal virus binding and disassembly 

    Sandekian, Véronique; Lemay, Guy (Elsevier, 2015-01-01)
    In a recent study, the serotype 3 Dearing strain of mammalian orthoreovirus was adapted to Vero cells; cells that exhibit a limited ability to support the early steps of reovirus uncoating and are unable to produce interferon as an antiviral response ...
  • Ammonia : this is not the end but rather the end of the beginning 

    Weiss, Nicolas; Dam, Gitte; Rose, Christopher (Elsevier, 2018-04)
    Hepatic encephalopathy (HE) represents a wide spectrum of neurological or neuropsychological symptoms caused by liver disease and/or portosystemic shunts. The major role of hyperammonemia in association with systemic inflammation and oxidative stress ...
  • Ammonia toxicity: from head to toe? 

    Dasarathy, Srinivasan; Mookerjee, Rajeshwar P.; Rackayova, Veronika; Rangroo Thrane, Vinita; Vairappan, Balasubramaniyan; Ott, Peter; Rose, Christopher (Springer, 2016-12)
    Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues. It is known that the toxic ramifications of ammonia primarily touch the brain and cause ...
  • Ammonia: more than a neurotoxin? 

    Rose, Christopher (2014)
  • AnaBench: a Web/CORBA-based workbench for biomolecular sequence analysis 

    Badidi, Elarbi; De Sousa, Cristina; Lang, Franz Bernd; Burger, Gertraud (2003)
    BACKGROUND:Sequence data analyses such as gene identification, structure modeling or phylogenetic tree inference involve a variety of bioinformatics software tools. Due to the heterogeneity of bioinformatics tools in usage and data requirements, ...