Browsing Faculté de médecine – Travaux et publications by Title
Now showing items 294-313 of 710
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Haplotype analysis suggest common founders in carriers of the recurrent BRCA2 mutation, 3398delAAAAG, in French Canadian hereditary breast and/ovarian cancer families
(2006)BACKGROUND:The 3398delAAAAG mutation in BRCA2 was recently found to recur in breast and/or ovarian cancer families from the French Canadian population of Quebec, a population that has genetic attributes consistent with a founder effect. To characterize ... -
Have we reproduced Rat Park? Conceptual but not direct replication of the protective effects of social and environmental enrichment in addiction
(Neuroscience Center HiLife, 2020-08-13)The Rat Park studies are classic experiments in addiction neuroscience, yet they have not been successfully replicated directly and several serious methodological criticisms have been raised. However, the conceptual reproducibility of the Rat Park ... -
HCO3 dependent impact of Na+,K+, 2Cl cotransport in vascular smooth muscle excitation-contraction coupling
(Krager, 2009)In smooth muscles, inhibition of Na(+),K(+),2Cl(-) cotransport (NKCC) by bumetanide decreased intracellular Cl(-) content ([Cl(-)](i)) and suppressed the contractions triggered by diverse stimuli. This study examines whether or not bicarbonate, a ... -
Health and literacy: the Mini-Med School and the Literacy Foundation working together to reach native children
(2016-05-18)The Mini-Med School (MMS) aims to motivate Native children to stay in school, introduce them to the health professions and encourage them to have healthy living practices. As reading skills play a major role in student retention, the MMS, in collaboration ... -
Health professionals’ and patients’ perspectives on pelvic floor muscle training adherence : 2011 ICS State-of-the-Science Seminar research paper IV of IV
(2015-08-12)Aims There is scant information on pelvic floor muscle training (PFMT) adherence barriers and facilitators. A web-based survey was conducted (1) to investigate whether responses from health professionals and the public broadly reflected findings in ... -
Hemodynamic changes during posterior epilepsies: an eeg-fnirs study
(Elsevier, 2014)Posterior epilepsies are relatively rare, mainly suspected clinically by the presence of visual auras. Functional near-infrared spectroscopy (fNIRS) is an emerging non-invasive imaging technique that has the potential to monitor hemodynamic changes ... -
Hepatic encephalopathy : from metabolic to neurodegenerative
(Elsevier, 2021-06-15)Hepatic encephalopathy (HE) is a neuropsychiatric syndrome of both acute and chronic liver disease. As a metabolic disorder, HE is considered to be reversible and therefore is expected to resolve following the replacement of the diseased liver with a ... -
Hepatic encephalopathy : novel insights into classification, pathophysiology and therapy
(Elsevier, 2020-10-21)Hepatic encephalopathy (HE) is a frequent and serious complication of both chronic liver disease and acute liver failure. HE manifests as a wide spectrum of neuropsychiatric abnormalities, from subclinical changes (mild cognitive impairment) to marked ... -
Hepatitis C Virus seroconversion among persons who inject drugs in relation to primary care physician visiting: The potential role of primary healthcare in a combined approach to Hepatitis C prevention
(Elsevier, 2015-10)Background: Meaningful reductions in Hepatitis C Virus (HCV) transmission rates among persons who inject drugs (PWID) require a comprehensive prevention approach, including access to harm reduction measures and to healthcare-related interventions, such ... -
Hepatocellular carcinoma imaging systems : why they exist, how they have evolved, and how they differ
(Springer, 2017-08-24)Over the past 16 years, several scientific organizations have proposed systems that incorporate imaging for surveillance, diagnosis, staging, treatment, and monitoring of treatment response of hepatocellular carcinoma (HCC). These systems are needed ... -
The Hepatokine TSK does not affect brown fat thermogenic capacity, body weight gain, and glucose homeostasis
(Elsevier, 2019-10-04)Objectives Hepatokines are proteins secreted by the liver that impact the functions of the liver and various tissues through autocrine, paracrine, and endocrine signaling. Recently, Tsukushi (TSK) was identified as a new hepatokine that is induced by ... -
Heretical thoughts into hepatic encephalopathy
(Elsevier & European Association for the Study of the Liver, 2022-03-27)Clinical progress in the development of new diagnostic modalities and therapeutic strategies for the management of patients with hepatic encephalopathy has lagged behind the vast knowledge that has been generated from basic studies. In this article, ... -
Heterotachy and long-branch attraction in phylogenetics
(2005)BACKGROUND:Probabilistic methods have progressively supplanted the Maximum Parsimony (MP) method for inferring phylogenetic trees. One of the major reasons for this shift was that MP is much more sensitive to the Long Branch Attraction (LBA) artefact ... -
High postoperative portal venous flow pulsatility indicates right ventricular dysfunction and predicts complications in cardiac surgery patients
(Elsevier, 2018-11-28)Background Right ventricular failure after cardiac surgery is associated with morbidity and mortality. Right ventricular dysfunction results in hepatic venous congestion, which impacts the portal circulation. We aimed to determine whether an increased ... -
HIV-1 envelope glycoprotein amino acids signatures associated with clade B transmitted/founder and recent viruses
(MDPI, 2019-11-01)Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude of virions present during transmission. They possess the capacity to establish infection and viral dissemination in a new host. Deciphering ... -
HIV-1 envelope sequence-based diversity measures for identifying recent infections
(Public Library of Science, 2017-12-28)Identifying recent HIV-1 infections is crucial for monitoring HIV-1 incidence and optimizing public health prevention efforts. To identify recent HIV-1 infections, we evaluated and compared the performance of 4 sequence-based diversity measures including ... -
HIV-1 Vpr induces the K48-linked polyubiquitination and proteasomal degradation of target cellular proteins to activate ATR and promote G2 arrest
(2010)HIV-1 viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by a mechanism involving the activation of the DNA damage sensor ATR. We and others recently showed that Vpr performs this function by subverting the activity of the DDB1-CUL4A ... -
HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing
(2010)HIV upregulates cell-surface expression of specific ligands for the activating NKG2D receptor, including ULBP-1, -2, -3, but not MICA or MICB, in infected cells both in vitro and in vivo. However, the viral factor(s) involved in NKG2D ligand expression ... -
How fast and how often: the pharmacokinetics of drug use are decisive in addiction
(2015-09)How much, how often and how fast a drug reaches the brain determine the behavioural and neuroplastic changes associated with the addiction process. Despite the critical nature of these variables, the drug addiction field often ignores pharmacokinetic ...