Faculté de médecine – Travaux et publications
Cette collection accueille les publications savantes et d’autres types de travaux d’auteur.e.s associé.e.s à cette unité. Voir aussi les collections Thèses et mémoires et Production étudiante de l'unité.
Recent Submissions
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PD-1 endocytosis unleashes the cytolytic potential of check-point blockade in tumor immunity
(2024)PD-1 immune checkpoint blockade (ICB) is now a promising first-line treatment for many cancers. While the steric blockade of PD-1 binding to its ligand plays a role, the role of internalisation in promoting the efficacy of ICB has not been explored. ... -
Estrogen and testosterone in concert with EFNB3 regulate vascular smooth muscle cell contractility and blood pressure
(American physiological society, 2016-02-05)EPH kinases and their ligands, ephrins (EFNs), have vital and diverse biological functions, although their function in blood pressure (BP) control has not been studied in detail. In the present study, we report that Efnb3 gene knockout (KO) led to ... -
Molecular insights into the normal operation, regulation, and multisystemic roles of K+-Cl− cotransporter 3 (KCC3)
(American physiological society, 2017)Long before the molecular identity of the Na+-dependent K+-Cl− cotransporters was uncovered in the mid-nineties, a Na+-independent K+-Cl− cotransport system was also known to exist. It was initially observed in sheep and goat red blood cells where it ... -
Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity
(Nature research, 2024-05-03)COVID-19, caused by SARS-CoV-2, can lead to a severe inflammatory disease characterized by significant lymphopenia. However, the underlying cause for the depletion of T-cells in COVID-19 patients remains incompletely understood. In this study, we ... -
Enjeux et défis de la prise en charge du bruit ferroviaire en aménagement et en urbanisme : un guide d’orientation
(2024-02-19)Cet ouvrage vise à sensibiliser les divers intervenants quant aux tenants et aboutissants de l’environnement sonore, en particulier à ce qui a trait au bruit ferroviaire, et aux enjeux de sa prise en charge en aménagement. Empruntant la forme d’un ... -
COOK technology to support meal preparation following a severe traumatic brain injury : a usability mixed-methods single-case study in a real-world environment
(Taylor and Francis, 2023-10-13)Introduction Following a traumatic brain injury (TBI), meal preparation may become challenging as it involves multiple cognitive abilities and sub-tasks. To support this population, the Cognitive Orthosis for coOKing (COOK) was developed in partnership ... -
Facilitators and obstacles to the use of a cognitive orthosis for meal preparation within the homes of adults with a moderate to severe traumatic brain injury : informal caregivers and health-care professionals’ perspectives
(Taylor and Francis, 2021-01-04)A cognitive orthosis named COOK was developed and implemented to facilitate meal preparation for adults with severe traumatic brain injury (TBI) living in an alternative housing unit. This study aimed to explore facilitators and barriers to the potential ... -
Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease
(Wiley, 2024-04-29)Hepatic encephalopathy (HE) is defined as decline in neurological function during chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of fibrosis/cirrhosis and has also been documented to directly impact the brain. ...