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2021 ISHEN guidelines on animal models of hepatic encephalopathy
(Wiley, 2021-04-01)
This working group of the International Society of Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) was commissioned to summarize and update current efforts in the development and characterization of animal models ...
Induction of systemic oxidative stress leads to brain oedema in portacaval shunted rats
(Wiley, 2013-11-25)
Background & Aims The pathogenesis of hepatic encephalopathy (HE) is multifactorial and often associated with the
development of brain oedema. In addition to ammonia playing a central role, systemic oxidative stress is ...
Bile‐duct ligation renders the brain susceptible to hypotension induced neuronal degeneration : implications of ammonia
Hypotension in hepatic encephalopathy
(Wiley, 2020-12-31)
Hepatic encephalopathy (HE) is a debilitating neurological complication of cirrhosis. By definition, HE is considered a reversible disorder, and therefore HE should resolve following liver transplantation (LT). However, ...
Elevated cerebral lactate : implications in the pathogenesis of hepatic encephalopathy
(Springer, 2014-06-11)
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver
failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation,
but ...
Astrocyte glutamine synthetase : pivotal in health and disease
(Portland Press, 2013)
The multifunctional properties of astrocytes signify their importance in brain physiology and neurological function. In addition to defining the brain architecture, astrocytes are primary elements of brain ion, pH and ...
Nutritional strategies to manage malnutrition and sarcopenia following liver transplantation : a narrative review
(MDPI, 2023-02-10)
Persisting or newly developed malnutrition and sarcopenia after liver transplant (LT) are correlated with adverse health outcomes. This narrative review aims to examine the literature regarding nutrition strategies to ...
Sex is associated with differences in oxidative stress and susceptibility to severe hepatic encephalopathy in bile-duct ligated rats
(Wiley, 2022-06-30)
Hepatic encephalopathy (HE) is a debilitating neurological complication of chronic liver disease (CLD). Hyperammonemia plays an important role in HE’s pathogenesis, acting synergistically with systemic oxidative stress. ...
The association between FABP7 serum levels with survival and neurological complications in acetaminophen-induced acute liver failure : a nested case–control study
(Springer, 2017)
Background: Acetaminophen (APAP)-induced acute liver failure (ALF) is associated with signifcant mortality due to
intracranial hypertension (ICH), a result of cerebral edema (CE) and astrocyte swelling. Brain-type fatty ...
Plasmatic osmolality and hepatic encephalopathy : a new player on the field?
(Wiley, 2020-08-31)
Nutritional education strategies for patients with cirrhosis : a narrative review
(Elsevier, 2023-06-30)
Background
Patients with cirrhosis suffer from many complications, including malnutrition, which must be managed promptly and effectively by the healthcare team. Educating patients about their medical condition, the risk ...