Now showing items 1-20 of 317

  • Autophagy drives fibroblast senescence through MTORC2 regulation 

    Autophagy, senescence and myofibroblast differentiation
    Bernard, Monique; Yang, Bing; Migneault, Francis; Turgeon, Julie; Dieudé, Mélanie; Olivier, Marc-Alexandre; Cardin, Guillaume B.; El-Diwany, Mostafa; Underwood, Katy; Rodier, Francis; Hébert, Marie-Josée (Taylor & Francis, 2020-01-13)
    Sustained macroautophagy/autophagy favors the differentiation of fibroblasts into myofibroblasts. Cellular senescence, another means of responding to long-term cellular stress, has also been linked to myofibroblast differentiation and fibrosis. Here, ...
  • Analysis of common and rare VPS13C variants in late-onset Parkinson disease 

    Rudakou, Uladzislau; Ruskey, Jennifer A.; Krohn, Lynne; Laurent, Sandra B.; Spiegelman, Dan; Greenbaum, Lior; Yahalom, Gilad; Desautels, Alex; Montplaisir, Jacques-Yves; Fahn, Stanley; Waters, Cheryl; Levy, Oren; Kehoe, Caitlin M.; Narayan, Sushma; Dauvilliers, Yves; Dupré, Nicolas; Hassin-Baer, Sharon; Alcalay, Roy N.; Rouleau, Guy; Fon, Edward A.; Gan-Or, Ziv (Lippincott, Williams and Wilkins, 2020-01-09)
    Objective We aimed to study the role of coding VPS13C variants in a large cohort of patients with lateonset Parkinson disease (PD) (LOPD). Methods VPS13C and its untranslated regions were sequenced using targeted next-generation sequencing in 1,567 ...
  • HIV-1 envelope glycoprotein amino acids signatures associated with clade B transmitted/founder and recent viruses 

    Kafando, Alexis; Martineau, Christine; El-Far, Mohamed; Fournier, Eric; Doualla-Bell, Florence; Serhir, Bouchra; Kazienga, Adama; Sangaré, Mohamed Ndongo; Sylla, Mohamed; Chamberland, Annie; Charest, Hugues; Tremblay, Cécile (MDPI, 2019-11-01)
    Background: HIV-1 transmitted/founder viruses (TF) are selected during the acute phase of infection from a multitude of virions present during transmission. They possess the capacity to establish infection and viral dissemination in a new host. Deciphering ...
  • A short-term assessment of nascent HIV-1 transmission clusters among newly diagnosed individuals using envelope sequence-based phylogenetic analyses 

    Kafando, Alexis; Serhir, Bouchra; Doualla-Bell, Florence; Fournier, Eric; Sangaré, Mohamed Ndongo; Martineau, Christine; Sylla, Mohamed; Chamberland, Annie; El-Far, Mohamed; Charest, Hugues; Tremblay, Cécile (Mary Ann Liebert, 2019-10-01)
    The identification of transmission clusters (TCs) of HIV-1 using phylogenetic analyses can provide insights into viral transmission network and help improve prevention strategies. We compared the use of partial HIV-1 envelope fragment of 1,070 bp ...
  • Neuroscience publishing is too important to leave to publishers 

    Khoo, Shaun Yon-Seng (Episteme Health Inc., 2019-06)
    Almost every open access neuroscience journal is pay-to-publish. This leaves neuroscientists with a choice of submitting to journals that not all of our colleagues can legitimately access and choosing to pay large sums of money to publish open access. ...
  • Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation 

    Ernst, Monique; Benson, Brenda; Artiges, Eric; Gorka, Adam X.; Lemaître, Hervé; Lago, Tiffany; Miranda, Ruben; Banaschewski, Tobias; Bokde, Arun W. L.; Bromberg, Uli; Brühl, Rüdiger; Büchel, Christian; Cattrell, Anna; Conrod, Patricia; Desrivières, Sylvane; Fadai, Tahmine; Flor, Herta; Grigis, Antoine; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Grimmer, Yvonne; Heinz, Andreas; Kappel, Viola; Nees, Frauke; Papadopoulos Orfanos, Dimitri; Penttilä, Jani; Poustka, Luise; Smolka, Michael N.; Stringaris, Argyris; Struve, Maren; Van Noort, Betteke M.; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Grillon, Christian; Paillère-Martinot, Marie-Laure; Martinot, Jean-Luc; IMAGEN Consortium (Springer Nature, 2019-02-25)
    This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN’s function may interact with ...
  • Article processing charge hyperinflation and price insensitivity : an open access sequel to the serials crisis 

    Khoo, Shaun Yon-Seng (LIBER, 2019)
    Open access publishing has frequently been proposed as a solution to the serials crisis, which involved unsustainable budgetary pressures on libraries due to hyperinflation of subscription costs. The majority of open access articles are published in ...
  • A single mutation in the mammalian orthoreovirus S1 gene is responsible for increased interferon sensitivity in a virus mutant selected in Vero cells 

    Reovirus interferon sensitivity
    Lanoie, Delphine; Côté, Stéphanie; Degeorges, Emmanuelle; Lemay, Guy (Elsevier, 2018-12-19)
    In a previous study, a mammalian orthoreovirus mutant was isolated based on its increased ability to infect interferon-defective Vero cells and was referred to as Vero-cellsadapted virus (VeroAV). This virus exhibits reduced ability to resist the ...
  • A brainstem neural substrate for stopping locomotion 

    Grätsch, Swantje; Auclair, François; Demers, Olivier; Auguste, Emmanuella; Hanna, Amer; Büschges, Ansgar; Dubuc, Réjean (Society for Neuroscience, 2018-12-12)
    Locomotion occurs sporadically and needs to be started, maintained, and stopped. The neural substrate underlying the activation of locomotion is partly known, but little is known about mechanisms involved in termination of locomotion. ...
  • Prenatal, concurrent, and sex-specific associations between blood lead concentrations and IQ in preschool Canadian children 

    Desrochers-Couture, Mireille; Oulhote, Youssef; Arbuckle, Tye; Fraser, William; Séguin, Jean; Ouellet, Emmanuel; Forget-Dubois, Nadine; Ayotte, Pierre; Boivin, Michel; Lanphear, Bruce P.; Muckle, Gina (Elsevier, 2018-11-02)
    Background: Lead exposure predicts altered neurodevelopment and lower intelligence quotient (IQ) in children, but few studies have examined this association in children who have relatively low blood lead concentrations. Objectives: To test the ...
  • Tensions living out professional values for physical therapists treating injured workers 

    Hudon, Anne; Ehrmann Feldman, Debbie; Hunt, Matthew (SAGE, 2018-10-10)
    Health care services provided by workers’ compensation systems aim to facilitate recovery for injured workers. However, some features of these systems pose barriers to high quality care and challenge health care professionals in their everyday work. ...
  • Stroke mimics transported by emergency medical services to a comprehensive stroke center : the magnitude of the problem 

    Neves Briard, Joël; Zewude, Rahel T.; Kate, Mahesh P.; Rowe, Brian H.; Buck, Brian; Butcher, Ken; Gioia, Laura C. (Elsevier, 2018-10)
    Background: Despite the use of validated prehospital stroke screens, stroke mimics are frequent among patients transported by Emergency Medical Services to the Emergency Department. We aimed to describe the frequency and characteristics of neurological ...
  • Universal cannabis outcomes from the Climate and Preventure (CAP) study : a cluster randomised controlled trial 

    Newton, Nicola C.; Teesson, Maree; Mather, Marius; Champion, Katrina E.; Barrett, Emma L.; Stapinski, Lexine; Carragher, Natacha; Kelly, Erin; Conrod, Patricia; Slade, Tim (BMC, 2018-09-25)
    Background: The Climate and Preventure (CAP) study was the first trial to assess and demonstrate the effectiveness of a combined universal and selective approach for preventing alcohol use and related harms among adolescents. The current paper reports ...
  • Children’s cortisol response to the transition from preschool to formal schooling : a review 

    Parent, Sophie; Lupien, Sonia; Herba, Catherine; Dupéré, Véronique; Gunnar, Megan R.; Séguin, Jean (Elsevier, 2018-09-14)
    This review examines the current state of knowledge regarding children's biological stress response during the transition from preschool to compulsory formal schooling, focusing on longitudinal studies that include repeated measures of cortisol ...
  • Automated external defibrillator geolocalization with a mobile application, verbal assistance or no assistance : a pilot randomized simulation (AED G-MAP) 

    Neves Briard, Joël; Grou-Boileau, Frédéric; El Bashtaly, Alaa; Spenard, Catherine; De Champlain, François; Homier, Valérie (Taylor & Francis, 2018-09-10)
    Background: Shockable rythms are common among victims of witnessed public out-of-hospital cardiac arrest (OHCA), but bystander defibrillation with a public automated external defibrillator (PAED) is rare. Instructions from the emergency medical ...
  • A direct interaction between two Restless Legs Syndrome predisposing genes : MEIS1 and SKOR1 

    Catoire, Helene; Faezeh, Sarayloo; Amar, Karim Mourabit; Apuzzo, Sergio; Grant, Alanna; Rochefort, Daniel; Xiong, Lan; Montplaisir, Jacques-Yves; Earley, Christopher J.; Tureck, Gustavo; Dion, Patrick A.; Rouleau, Guy (Nature research, 2018-08-15)
    Restless Legs syndrome (RLS) is a common sleep disorder for which the genetic contribution remains poorly explained. In 2007, the frst large scale genome wide association study (GWAS) identifed three genomic regions associated with RLS. MEIS1, BTBD9 ...
  • The interactive effects of parental knowledge with impulsivity and sensation seeking in adolescent substance use 

    Interactions in substance use
    Rioux, Charlie; Castellanos Ryan, Natalie; Parent, Sophie; Vitaro, Frank; Séguin, Jean (Springer, 2018-06-29)
    This study examined whether interactions of parental knowledge of adolescent’s whereabouts with impulsivity and sensation seeking in the prediction of adolescent substance use supported the diathesis–stress or differential susceptibility model in 230 ...
  • Prenatal exposure to polybrominated diphenyl ethers and predisposition to frustration at 7 months : results from the MIREC study 

    Oulhote, Youssef; Tremblay, Émilie; Arbuckle, Tye; Fraser, William; Lemelin, Jean‐Pascal; Séguin, Jean; Ouellet, Emmanuel; Forget-Dubois, Nadine; Ayotte, Pierre; Boivin, Michel; Dionne, Ginette; Lanphear, Bruce P.; Muckle, Gina (Elsevier, 2018-06-22)
    Background: Prenatal exposure to polybrominated diphenyl ethers (PBDEs) has been associated with cognitive deficits and behavioral problems in children. To date, no study has examined this exposure in association with neurobehavioral development in ...
  • Longitudinal association between peer victimization and sleep problems in preschoolers: the moderating role of parenting 

    Peer victimization and sleep problems
    Bilodeau, François; Brendgen, Mara; Vitaro, Frank; Côté, Sylvana; Tremblay, Richard Ernest; Touchette, Évelyne; Montplaisir, Jacques-Yves; Boivin, Michel (Taylor & Francis, 2018-06-11)
    This study examined the moderating role of parental behaviors in the longitudinal link between peer victimization and sleep problems during preschool. The sample consisted of 1,181 children (594 girls) attending day care between the ages of 3 and 6 ...
  • More symmetrical gait after split-belt treadmill walking does not modify dynamic and postural balance in individuals post-stroke 

    Miéville, Carole; Lauzière, Séléna; Betschart, Martina; Nadeau, Sylvie; Duclos, Cyril (Elsevier, 2018-04-24)
    Spontaneous gait is often asymmetrical in individuals post-stroke, despite their ability to walk more symmetrically on demand. Given the sensorimotor deficits in the paretic limb, this asymmetrical gait may facilitate balance maintenance. We used a ...