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dc.contributor.authorFecteau, Shirley
dc.contributor.authorLassonde, Maryse
dc.contributor.authorThéoret, Hugo
dc.date.accessioned2007-01-05T21:56:42Z
dc.date.available2007-01-05T21:56:42Z
dc.date.issued2006
dc.identifier.citationFecteau, S., Lassonde, M., & Théoret, H. (2006). Intrahemispheric dysfunction in primary motor cortex without corpus callosum: a transcranial magnetic stimulation study. BMC Neurology, 6(1), 21.
dc.identifier.urihttp://www.biomedcentral.com/1471-2377/6/21
dc.identifier.urihttp://hdl.handle.net/1866/660
dc.format.extent421516 bytes
dc.format.mimetypeapplication/pdf
dc.rightsCeci est un article en accès libre diffusé sous une licence Creative Commons Paternité laquelle permet une libre utilisation, diffusion et reproduction de l'article sous toutes formes, à la condition de l'attribuer à l'auteur en citant son nom. This is an open access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.titleIntrahemispheric dysfunction in primary motor cortex without corpus callosum: a transcranial magnetic stimulation study
dc.typeArticle
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dc.identifier.doi10.1186/1471-2377-6-21
dcterms.abstractBACKGROUND:The two human cerebral hemispheres are continuously interacting, through excitatory and inhibitory influences and one critical structure subserving this interhemispheric balance is the corpus callosum. Interhemispheric neurophysiological abnormalities and intrahemispheric behavioral impairments have been reported in individuals lacking the corpus callosum. The aim of this study was to examine intrahemispheric neurophysiological function in primary motor cortex devoid of callosal projections.METHODS:Intracortical excitatory and inhibitory systems were tested in three individuals with complete agenesis of the corpus callosum and sixteen healthy individuals. These systems were assessed using transcranial magnetic stimulation (TMS) protocols: motor threshold at rest, paired-pulse curve, and cortical silent period.RESULTS:TMS revealed no difference between the patient and control groups on the motor threshold measure, as well as intracortical facilitation and intracortical inhibition systems as tested by paired stimulation. However, intrahemispheric inhibitory function was found to be abnormal in participants without callosal projections, as the cortical silent period duration was significantly increased in the patient group.CONCLUSION:These data suggest that in addition to previously reported impaired interhemispheric function, patients lacking the entire corpus callosum also display abnormal intrahemispheric excitability of the primary motor cortex.en
dcterms.bibliographicCitationBMC Neurology ; 6(1), 21.
dcterms.descriptionAffiliation: Département de Psychologie, Université de Montréal
dcterms.isPartOfurn:ISSN:1471-2377
UdeM.VersionRioxxVersion acceptée / Accepted Manuscript


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Ceci est un article en accès libre diffusé sous une licence Creative Commons Paternité laquelle permet une libre utilisation, diffusion et reproduction de l'article sous toutes formes, à la condition de l'attribuer à l'auteur en citant son nom. This is an open access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
RightsCeci est un article en accès libre diffusé sous une licence Creative Commons Paternité laquelle permet une libre utilisation, diffusion et reproduction de l'article sous toutes formes, à la condition de l'attribuer à l'auteur en citant son nom. This is an open access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.