dc.contributor.author | Van Oosterom, Adriaan | |
dc.contributor.author | Jacquemet, Vincent | |
dc.date.accessioned | 2024-04-17T17:08:46Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2024-04-17T17:08:46Z | |
dc.date.issued | 2008-08-13 | |
dc.identifier.uri | http://hdl.handle.net/1866/32922 | |
dc.publisher | Elsevier | fr |
dc.rights | CC BY-NC-ND 4.0 DEED Attribution - Pas d’Utilisation Commerciale - Pas de Modification 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.fr | |
dc.subject | Activation recovery interval | fr |
dc.subject | Isotonic load | fr |
dc.subject | Velocity of repolarization | fr |
dc.subject | Curvature | fr |
dc.title | The effect of tissue geometry on the activation recovery interval of atrial myocytes | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Département de pharmacologie et physiologie | fr |
dc.identifier.doi | 10.1016/j.physd.2008.08.003 | |
dcterms.abstract | The propagation of electric activity inside a
realistically-shaped, thick-walled model of the atria was studied.
The membrane kinetics was based on the formulations of
Courtemanche, Ramirez and Nattel. In spite of the assumed
uniformity of all kinetics parameters, diffusion parameters, the
activation recovery intervals revealed values in a range of about
20 ms, having a clearly distinct spatial distribution, with higher
values close to the site of activation and lower ones at sites
where activation ends. This paper presents an analysis of this
phenomenon based on similar observations made on propagation
along the classic models of cable and disk, as well as along
the surface of a spherical shell and a diabolo-shaped shell.
Propagation in the latter three geometries is treated under axialsymmetric conditions, for which dedicated analytical expressions
of the diffusion term are described. The results indicate that the
major effects can be directly attributed to step discontinuity in the
conductivity of the medium surrounding the locations of initial
and final depolarization. Overall geometry of the myocardial
wall determines the smooth distribution of activation recovery
intervals in the medium, showing local maxima around the points
of initiation and local minima at locations where depolarization
ends. The points are determined by the location of the stimulation
sites involved and overall tissue geometry. | fr |
dcterms.isPartOf | urn:ISSN:0167-2789 | fr |
dcterms.isPartOf | urn:ISSN:1872-8022 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | https://doi.org/10.1016/j.physd.2008.08.003 | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Physica D : nonlinear phenomena | fr |
oaire.citationVolume | 238 | fr |
oaire.citationIssue | 11-12 | fr |
oaire.citationStartPage | 962 | fr |
oaire.citationEndPage | 968 | fr |