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dc.contributor.authorKam, Korey
dc.contributor.authorParekh, Ankit
dc.contributor.authorSharma, Ram A.
dc.contributor.authorAndrade, Andreia
dc.contributor.authorLewin, Monica
dc.contributor.authorCastillo, Bresne
dc.contributor.authorBubu, Omonigho M.
dc.contributor.authorChua, Nicholas J.
dc.contributor.authorMiller, Margo D.
dc.contributor.authorMullins, Anna E.
dc.contributor.authorGlodzik, Lidia
dc.contributor.authorMosconi, Lisa
dc.contributor.authorGosselin, Nadia
dc.contributor.authorPrathamesh, Kulkarni
dc.contributor.authorChen, Zhe
dc.contributor.authorBlennow, Kaj
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorBagchi, Nisha
dc.contributor.authorCavedoni, Bianca
dc.contributor.authorRapoport, David M.
dc.contributor.authorAyappa, Indu
dc.contributor.authorDe Leon, Mony J.
dc.contributor.authorPetkova, Eva
dc.contributor.authorVarga, Andrew W.
dc.contributor.authorOsorio, Ricardo S.
dc.date.accessioned2020-12-17T13:48:10Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2020-12-17T13:48:10Z
dc.date.issued2019-02-21
dc.identifier.urihttp://hdl.handle.net/1866/24096
dc.publisherBMCfr
dc.rightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleSleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers : novel roles for sleep spindles and taufr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dc.identifier.doi10.1186/s13024-019-0309-5
dcterms.abstractBackground: Based on associations between sleep spindles, cognition, and sleep-dependent memory processing, here we evaluated potential relationships between levels of CSF Aβ42, P-tau, and T-tau with sleep spindle density and other biophysical properties of sleep spindles in a sample of cognitively normal elderly individuals. Methods: One-night in-lab nocturnal polysomnography (NPSG) and morning to early afternoon CSF collection were performed to measure CSF Aβ42, P-tau and T-tau. Seven days of actigraphy were collected to assess habitual total sleep time. Results: Spindle density during NREM stage 2 (N2) sleep was negatively correlated with CSF Aβ42, P-tau and T-tau. From the three, CSF T-tau was the most significantly associated with spindle density, after adjusting for age, sex and ApoE4. Spindle duration, count and fast spindle density were also negatively correlated with T-tau levels. Sleep duration and other measures of sleep quality were not correlated with spindle characteristics and did not modify the associations between sleep spindle characteristics and the CSF biomarkers of AD. Conclusions: Reduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline.fr
dcterms.isPartOfurn:ISSN:1750-1326fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantPMID: 30791922 PMCID: PMC6385427 DOI: 10.1186/s13024-019-0309-5fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleMolecular neurodegenerationfr
oaire.citationVolume14fr
oaire.citationIssue10fr


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Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.
RightsCe document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License.