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Inconsistencies between measures of cognitive dysfunction in childhood acute lymphoblastic leukemia survivors : description and understanding

dc.contributor.authorLeclerc, Andrée-Anne
dc.contributor.authorLippé, Sarah
dc.contributor.authorBertout, Laurence
dc.contributor.authorChapados, Pascale
dc.contributor.authorBoulet-Craig, Aubrée
dc.contributor.authorDrouin, Simon
dc.contributor.authorKrajinovic, Maja
dc.contributor.authorLaverdière, Caroline
dc.contributor.authorMichon, Bruno
dc.contributor.authorRobaey, Philippe
dc.contributor.authorRondeau, Émélie
dc.contributor.authorSinnett, Daniel
dc.contributor.authorSultan, Serge
dc.subjectChildhood leukemiafr
dc.subjectCognitive testfr
dc.subjectWorking memoryfr
dc.titleInconsistencies between measures of cognitive dysfunction in childhood acute lymphoblastic leukemia survivors : description and understandingfr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dcterms.abstractObjectives The frequency of cognitive difficulties in childhood cancer survivors varies according to the measurement strategy. The goal of this research is to (a) describe agreements and differences between measures of working memory and attention (b) identify contributors of these differences, such as emotional distress, affects, and fatigue. Methods We used data available for 138 adults successfully treated for childhood acute lymphoblastic leukemia (ALL) (PETALE cohort). Working memory and attention were assessed using subtests from the WAIS‐IV and self‐reported questionnaires (BRIEF‐SR and CAARS‐S:L). Potential contributors included emotional distress, anxiety, depression (BSI‐18), affects (PANAS), and fatigue (PedsQL‐MFS). We explored measurement agreements and differences using diagnostic indices and multivariate regression models. Results The frequencies of working memory and attention deficits were higher when using cognitive tests (15%‐21%) than with self‐reports (10%‐11%). Self‐reported questionnaires showed high specificity (median 0.87) and low sensitivity (median 0.10), suggesting they did not reliably identify positive cases on cognitive tests. We identified negative affectivity as a possible contributor to inconsistencies between self‐report and test results. Conclusions When measuring working memory and attention in childhood ALL survivors, cognitive test results and self‐reports should not be considered equivalent. At best, self‐report may be used for screening (high specificity), but not to assess prevalence in large samples. Self‐reported difficulties are also probably influenced by the negative mood in this
dcterms.alternativeCognitive dysfunction in childhood leukemia survivorsfr
UdeM.ReferenceFournieParDeposantLeclerc AA, Lippé S, Bertout L, Chapados P, Boulet-Craig A, Drouin S, Krajinovic M, Laverdière C, Michon B, Robaey P, Rondeau É, Sinnett D, Sultan S. Inconsistencies between measures of cognitive dysfunction in childhood acute lymphoblastic leukemia survivors: Description and understanding. Psychooncology. 2020 Jul;29(7):1201-1208. doi: 10.1002/pon.5410. Epub 2020 Jun
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr

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