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dc.contributor.authorBaril, Andrée‐Ann
dc.contributor.authorGagnon, Katia
dc.contributor.authorDescoteaux, Maxime
dc.contributor.authorBedetti, Christophe
dc.contributor.authorChami, Sirin
dc.contributor.authorSanchez, Erlan
dc.contributor.authorMontplaisir, Jacques-Yves
dc.contributor.authorDe Beaumont, Louis
dc.contributor.authorGilbert, Danielle
dc.contributor.authorPoirier, Judes
dc.contributor.authorPelleieux, Sandra
dc.contributor.authorOsorio, Ricardo S.
dc.contributor.authorCarrier, Julie
dc.contributor.authorGosselin, Nadia
dc.date.accessioned2020-11-23T15:43:05Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2020-11-23T15:43:05Z
dc.date.issued2020-03-13
dc.identifier.urihttp://hdl.handle.net/1866/24050
dc.publisherWileyfr
dc.rightsCe document est mis à disposition selon les termes de la Licence Creative Commons Attribution - Pas d’utilisation commerciale 4.0 International. / This work is licensed under a Creative Commons Attribution - NonCommercial 4.0 International License.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAgingfr
dc.subjectDiffusion tensor imagingfr
dc.subjectHypoxiafr
dc.subjectMagnetic resonance imagingfr
dc.subjectSleep and neurodegenerative disordersfr
dc.subjectSleep‐disordered breathingfr
dc.subjectWhite matterfr
dc.titleCerebral white matter diffusion properties and free‐water with obstructive sleep apnea severity in older adultsfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dc.identifier.doi10.1002/hbm.24971
dcterms.abstractCharacterizing the effects of obstructive sleep apnea (OSA) on the aging brain could be key in our understanding of neurodegeneration in this population. Our objective was to assess white matter properties in newly diagnosed and untreated adults with mild to severe OSA. Sixty‐five adults aged 55 to 85 were recruited and divided into three groups: control (apnea‐hypopnea index ≤5/hr; n = 18; 65.2 ± 7.2 years old), mild (>5 to ≤15 hr; n = 27; 64.2 ± 5.3 years old) and moderate to severe OSA (>15/hr; n = 20; 65.2 ± 5.5 years old). Diffusion tensor imaging metrics (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity, and mean diffusivity) were compared between groups with Tract‐Based Spatial Statistics within the white matter skeleton created by the technique. Groups were also compared for white matter hyperintensities volume and the free‐water (FW) fraction. Compared with controls, mild OSA participants showed widespread areas of lower diffusivity (p < .05 corrected) and lower FW fraction (p < .05). Participants with moderate to severe OSA showed lower AD in the corpus callosum compared with controls (p < .05 corrected). No between‐group differences were observed for FA or white matter hyperintensities. Lower white matter diffusivity metrics is especially marked in mild OSA, suggesting that even the milder form may lead to detrimental outcomes. In moderate to severe OSA, competing pathological responses might have led to partial normalization of diffusion metrics.fr
dcterms.isPartOfurn:ISSN:1065-9471fr
dcterms.isPartOfurn:ISSN:1097-0193fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantPMID: 32166865 PMCID: PMC7294053 DOI: 10.1002/hbm.24971fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleHuman brain mappingfr
oaire.citationVolume41fr
oaire.citationIssue10fr
oaire.citationStartPage2686fr
oaire.citationEndPage2701fr


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Ce document est mis à disposition selon les termes de la Licence Creative Commons Attribution - Pas d’utilisation commerciale 4.0 International. / This work is licensed under a Creative Commons Attribution - NonCommercial 4.0 International License.
RightsCe document est mis à disposition selon les termes de la Licence Creative Commons Attribution - Pas d’utilisation commerciale 4.0 International. / This work is licensed under a Creative Commons Attribution - NonCommercial 4.0 International License.