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Permalink: http://hdl.handle.net/1866/24049

Sleep spindles are resilient to extensive white matter deterioration

Article [Version of Record]
Thumbnail
Sanchez - Brain Communications 2020.pdf (555.0Kb)
Is part of
Brain communications ; vol. 2, no. 2.
Publisher(s)
Oxford University Press
2020-06-13
Author(s)
Sanchez, Erlan
Arbour, Caroline
El-Khatib, Héjar
Marcotte, Karine
Blais, Hélène
Baril, Andrée-Ann
Bedetti, Christophe
Descoteaux, Maxime
Lina, Jean-Marc
Gilbert, Danielle
Carrier, Julie
Gosselin, Nadia
Affiliation
  • Université de Montréal. Faculté des arts et des sciences. Département de psychologie
Keywords
  • Sleep
  • Spindles
  • White matter
  • TBI
  • Traumatic brain injury
Abstract(s)
Sleep spindles are an essential part of non-rapid eye movement sleep, notably involved in sleep consolidation, cognition, learning and memory. These oscillatory waves depend on an interaction loop between the thalamus and the cortex, which relies on a structural backbone of thalamo-cortical white matter tracts. It is still largely unknown if the brain can properly produce sleep spindles when it underwent extensive white matter deterioration in these tracts, and we hypothesized that it would affect sleep spindle generation and morphology. We tested this hypothesis with chronic moderate to severe traumatic brain injury (n ¼ 23; 30.5 6 11.1 years old; 17 m/6f), a unique human model of extensive white matter deterioration, and a healthy control group (n ¼ 27; 30.3 6 13.4 years old; 21m/6f). Sleep spindles were analysed on a full night of polysomnography over the frontal, central and parietal brain regions, and we measured their density, morphology and sigma-band power. White matter deterioration was quantified using diffusion-weighted MRI, with which we performed both whole-brain voxel-wise analysis (Tract-Based Spatial Statistics) and probabilistic tractography (with High Angular Resolution Diffusion Imaging) to target the thalamo-cortical tracts. Group differences were assessed for all variables and correlations were performed separately in each group, corrected for age and multiple comparisons. Surprisingly, although extensive white matter damage across the brain including all thalamo-cortical tracts was evident in the brain-injured group, sleep spindles remained completely undisrupted when compared to a healthy control group. In addition, almost all sleep spindle characteristics were not associated with the degree of white matter deterioration in the braininjured group, except that more white matter deterioration correlated with lower spindle frequency over the frontal regions. This study highlights the resilience of sleep spindles to the deterioration of all white matter tracts critical to their existence, as they conserve normal density during non-rapid eye movement sleep with mostly unaltered morphology. We show that even with such a severe traumatic event, the brain has the ability to adapt or to withstand alterations in order to conserve normal sleep spindles.
Other location(s)
https://doi.org/10.1093/braincomms/fcaa071
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  • Faculté des arts et des sciences – Département de psychologie - Travaux et publications [159]

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