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dc.contributor.authorSilventoinen, Karri
dc.contributor.authorBrendgen, Mara
dc.contributor.authorVitaro, Frank
dc.date.accessioned2020-06-29T17:11:00Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2020-06-29T17:11:00Z
dc.date.issued2019-07-31
dc.identifier.urihttp://hdl.handle.net/1866/23649
dc.subjectTwinsfr
dc.subjectInternational comparisonsfr
dc.subjectHeritabilityfr
dc.subjectHeightfr
dc.subjectBMIfr
dc.subjectBirth sizefr
dc.subjectEducationfr
dc.titleThe CODAT wins project : the current status and recent findings of collaborative project of development of anthropometrical measures in twinsfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. École de psychoéducationfr
dc.identifier.doi10.1017/thg.2019.35
dcterms.abstractThe COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2 ) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural– geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status.fr
dcterms.isPartOfurn:ISSN:1832-4274fr
dcterms.isPartOfurn:ISSN:1839-2628fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantSilventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., ... & Hjelmborg, J. V. B. (2019). The CODATwins project: The current status and recent findings of collaborative project of development of anthropometrical measures in twins. Twin Research and Human Genetics, 22(6), 800-808.fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleTwin research and human genetics
oaire.citationVolume22
oaire.citationIssue6
oaire.citationStartPage800
oaire.citationEndPage808


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