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dc.contributor.authorChiarella, Julian
dc.contributor.authorTremblay, Richard Ernest
dc.contributor.authorSzyf, Moshe
dc.contributor.authorProvençal, Nadine
dc.contributor.authorBooij, Linda
dc.date.accessioned2020-06-09T13:00:50Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2020-06-09T13:00:50Z
dc.date.issued2015
dc.identifier.urihttp://hdl.handle.net/1866/23420
dc.publisherCambridge University Pressfr
dc.subjectTwinsfr
dc.subjectEpigeneticsfr
dc.subjectMental healthfr
dc.subjectChild developmentfr
dc.subjectBirth weightfr
dc.subjectMonozygoticfr
dc.titleImpact of early environment on children's mental health : lessons from DNA methylation studies with monozygotic twinsfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dc.identifier.doi10.1017/thg.2015.84
dcterms.abstractOver the past decade, epigenetic analyses have made important contributions to our understanding of healthy development and a wide variety of adverse conditions such as cancer and psychopathology. There is increasing evidence that DNA methylation is a mechanism by which environmental factors influence gene transcription and, ultimately, phenotype. However, differentiating the effects of the environment from those of genetics on DNA methylation profiles remains a significant challenge. Monozygotic (MZ) twin study designs are unique in their ability to control for genetic differences because each pair of MZ twins shares essentially the same genetic sequence with the exception of a small number of de novo mutations and copy number variations. Thus, differences within twin pairs in gene expression and phenotype, including behavior, can be attributed in the majority of cases to environmental effects rather than genetic influence. In this article, we review the literature showing how MZ twin designs can be used to study basic epigenetic principles, contributing to understanding the role of early in utero and postnatal environmental factors on the development of psychopathology. We also highlight the importance of initiating longitudinal and experimental studies with MZ twins during pregnancy. This approach is especially important to identify: (1) critical time periods during which the early environment can impact brain and mental health development, and (2) the specific mechanisms through which early environmental effects may be mediated. These studies may inform the optimum timing and design for early preventive interventions aimed at reducing risk for psychopathology.fr
dcterms.isPartOfurn:ISSN:1832-4274fr
dcterms.isPartOfurn:ISSN:1832-4274fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantChiarella, J., Tremblay, R. E., Szyf, M., Provençal, N., & Booij, L. (2015). Impact of early environment on children's mental health: lessons from DNA methylation studies with monozygotic twins. Twin Research and Human Genetics, 18(6), 623-634.fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitleTwin research and human genetics
oaire.citationVolume18
oaire.citationIssue6
oaire.citationStartPage623
oaire.citationEndPage634


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