Education as a moderator of the relationship between episodic memory and amyloid load in normal aging
dc.contributor.author | Joannette, Maude | |
dc.contributor.author | Bocti, Christian | |
dc.contributor.author | Sévigny Dupont, Pénélope | |
dc.contributor.author | Lavallée, Marie Maxime | |
dc.contributor.author | Nikelski, Jim | |
dc.contributor.author | Vallet, Guillaume | |
dc.contributor.author | Chertkow, Howard | |
dc.contributor.author | Joubert, Sven | |
dc.date.accessioned | 2019-11-26T19:33:39Z | |
dc.date.available | MONTHS_WITHHELD:12 | fr |
dc.date.available | 2019-11-26T19:33:39Z | |
dc.date.issued | 2019-10-23 | |
dc.identifier.uri | http://hdl.handle.net/1866/22624 | |
dc.publisher | Oxford University Press | fr |
dc.subject | Biomarkers | fr |
dc.subject | Brain aging | fr |
dc.subject | Cognition | fr |
dc.subject | Cognitive reserve | fr |
dc.title | Education as a moderator of the relationship between episodic memory and amyloid load in normal aging | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté des arts et des sciences. Département de psychologie | fr |
dc.identifier.doi | 10.1093/gerona/glz235 | |
dcterms.abstract | The current study explored whether education, a proxy of cognitive reserve, modifies the association between episodic memory (EM) performance and βeta-amyloid load (Aβ), a biomarker of Alzheimer’s disease, in a cohort of cognitively normal older adults. One hundred and four participants (mean age 73.3 years) evenly spread out in three bands of education were recruited. Participants underwent neuropsychological assessment, structural MRI as well as PET imaging to quantify Aβ load. Moderation analyses and the Johnson–Neyman technique were carried out to examine the interaction of education with Aβ load to predict EM performance. Linear regressions were then performed within each group of education to better illustrate the interaction effect (all analyses were controlled for age and sex). The interaction between education and Aβ load was significant (p < .05) for years of education, reaching a cutoff point of 13.5 years, above which the relationship between Aβ load and EM was no longer significant. Similarly, significant associations were found between Aβ and EM among participants with secondary (p < .01) and preuniversity education (p < .01), but not with a university degree (p = .253). EM performance is associated with Aβ load in cognitively normal older individuals, and this relationship is moderated by educational attainment. | fr |
dcterms.isPartOf | urn:ISSN:1079-5006 | fr |
dcterms.isPartOf | urn:ISSN:1758-535X | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Joannette M, Bocti C, Dupont PS, Lavallée MM, Nikelski J, Vallet GT, Chertkow H, Joubert S. Education as a moderator of the relationship between episodic memory and amyloid load in normal aging. J Gerontol A Biol Sci Med Sci. 2019 Oct 23. pii: glz235. doi: 10.1093/gerona/glz235. [Epub ahead of print] PMID:31639181 | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Journals of gerontology | |
oaire.citationIssue | Series A |
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