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Permalink: http://hdl.handle.net/1866/22408

Sleep-wake disturbances in hospitalized patients with traumatic brain injury: association with brain trauma but not with an abnormal melatonin circadian rhythm

Article [Accepted Manuscript]
Thumbnail
Melatonin_SLEEP_PRODUCTION FILE_20190724_FULL.pdf (742.7Kb)
Is part of
Sleep
Publisher(s)
Oxford University Press
2019-09-28
Author(s)
Duclos, Catherine
Dumont, Marie
Paquet, Jean
Blais, Hélène
Van der Maren, Solenne
Menon, David K.
Bernard, Francis
Gosselin, Nadia
Affiliation
  • Université de Montréal. Faculté des arts et des sciences. Département de psychologie
Keywords
  • Sleep
  • Circadian rhythms
  • Traumatic brain injury
  • Melatonin
  • Actigraphy
  • Acute care
Abstract(s)
Study Objectives: To test whether the sleep-wake cycle disruption in patients hospitalized with traumatic brain injury (TBI) 1) is also found in patients with traumatic injuries other than TBI (nonTBI); and 2) is associated to a weaker or abnormal circadian clock signal. Methods: Forty-two non-mechanically ventilated and non-sedated patients hospitalized for moderate to severe TBI were compared to 34 non-TBI patients. They wore wrist actigraphs for 9.4±4.2 days, starting 19.3±12.6 days post-injury. Of these, 17 TBI and 14 non-TBI patients had their urine collected every hour for 25 h, starting 18.3±12.3 days post-injury. We calculated urinary 6-sulfatoxymelatonin concentration to obtain total 24 h excretion, excretion onset, offset, duration, amplitude and acrophase. Using Student’s t-tests, we compared groups on actigraphy (daytime activity ratio, nighttime total sleep time, and fragmentation index) and melatonin variables. We investigated associations between melatonin and actigraphy variables using Pearson’s correlations. Results: TBI patients had poorer daytime activity ratio (TBI: 77.5±9.4%; non-TBI: 84.6±6.9%), shorter nighttime total sleep time (TBI: 353.5±96.6 min; non-TBI: 421.2±72.2 min), and higher fragmentation index (TBI: 72.2±30.0; non-TBI: 53.5±23.6) (all p-values<0.01). A melatonin rhythm was present in both groups, and no group differences were found on melatonin variables. No associations were found between melatonin and actigraphy variables in TBI patients. Conclusion: Moderate to severe TBI patients have more serious sleep-wake disturbances than non-TBI patients hospitalized in the same environment, suggesting that the brain injury itself alters the sleepwake cycle. Despite their deregulated 24 h sleep-wake cycle, TBI patients have a normal circadian clock signal.
Other location(s)
https://doi.org/10.1093/sleep/zsz191
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  • Faculté des arts et des sciences – Département de psychologie - Travaux et publications [163]

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