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dc.contributor.authorJubault, Thomas
dc.contributor.authorBrambati, Simona Maria
dc.contributor.authorDegroot, Clotilde
dc.contributor.authorKullmann, Benoit
dc.contributor.authorStrafella, Antonio P.
dc.contributor.authorLafontaine, Anne-Louise
dc.contributor.authorChouinard, Sylvain
dc.contributor.authorMonchi, Oury
dc.date.accessioned2019-05-27T17:55:12Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2019-05-27T17:55:12Z
dc.date.issued2009-12-10
dc.identifier.urihttp://hdl.handle.net/1866/22015
dc.publisherPublic Library of Sciencefr
dc.titleRegional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRIfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. Département de psychologiefr
dc.identifier.doi10.1371/journal.pone.0008247
dcterms.abstractIdiopathic Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the dysfunction of dopaminergic dependent cortico-basal ganglia loops and diagnosed on the basis of motor symptoms (tremors and/or rigidity and bradykinesia). Post-mortem studies tend to show that the destruction of dopaminergic neurons in the substantia nigra constitutes an intermediate step in a broader neurodegenerative process rather than a unique feature of Parkinson’s disease, as a consistent pattern of progression would exist, originating from the medulla oblongata/pontine tegmentum. To date, neuroimaging techniques have been unable to characterize the pre-symptomatic stages of PD. However, if such a regular neurodegenerative pattern were to exist, consistent damages would be found in the brain stem, even at early stages of the disease. We recruited 23 PD patients at Hoenn and Yahr stages I to II of the disease and 18 healthy controls (HC) matched for age. T1-weighted anatomical scans were acquired (MPRAGE, 1 mm3 resolution) and analyzed using an optimized VBM protocol to detect white and grey matter volume reduction without spatial a priori. When the HC group was compared to the PD group, a single cluster exhibited statistical difference (p,0.05 corrected for false detection rate, 4287 mm3) in the brain stem, between the pons and the medulla oblongata. The present study provides in-vivo evidence that brain stem damage may be the first identifiable stage of PD neuropathology, and that the identification of this consistent damage along with other factors could help with earlier diagnosis in the future. This damage could also explain some nonmotor symptoms in PD that often precede diagnosis, such as autonomic dysfunction and sleep disorders.fr
dcterms.isPartOfurn:ISSN:1932-6203fr
dcterms.isPartOfurn:ISSN:1932-6203fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantJubault, T., S.M. Brambati, C. Degroot, B. Kullmann, A.P. Strafella, A.L. Lafontaine, S. Chouinard, and O. Monchi, Regional brain stem atrophy in idiopathic Parkinson's disease detected by anatomical MRI Oury Monchi, 2009. 4(12): p. e8247.fr
UdeM.VersionRioxxVersion publiée / Version of Recordfr
oaire.citationTitlePLoS one
oaire.citationVolume4
oaire.citationIssue12


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