dc.contributor.author | Brambati, Simona Maria | |
dc.contributor.author | Amici, Serena | |
dc.contributor.author | Racine, Caroline A. | |
dc.contributor.author | Neuhaus, John | |
dc.contributor.author | Miller, Zachary | |
dc.contributor.author | Ogar, Jennifer M. | |
dc.contributor.author | Dronkers, Nina | |
dc.contributor.author | Miller, Bruce L. | |
dc.contributor.author | Rosen, Howard J. | |
dc.contributor.author | Gorno-Tempini, Maria Luisa | |
dc.date.accessioned | 2019-05-27T14:16:29Z | |
dc.date.available | NO_RESTRICTION | fr |
dc.date.available | 2019-05-27T14:16:29Z | |
dc.date.issued | 2015-01-22 | |
dc.identifier.uri | http://hdl.handle.net/1866/21999 | |
dc.publisher | Elsevier | fr |
dc.rights | Ce document est mis à disposition selon les termes de la Licence Creative Commons Paternité 4.0 International. / This work is licensed under a Creative Commons Attribution 4.0 International License. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Longitudinal gray matter contraction in three variants of primary progressive aphasia : a tensor-based morphometry study | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté des arts et des sciences. Département de psychologie | fr |
dc.identifier.doi | 10.1016/j.nicl.2015.01.011 | |
dcterms.abstract | The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients with the semantic variant (svPPA), seven patients with the logopenic variant (lvPPA), and 29 age-matched, neurologically healthy controls were included in the study. All participants underwent longitudinal MRI, neuropsychological and language testing at baseline and at a 1-year follow-up. Tenser-based morphometry (TBM) was applied to T1-weighted MRI images in order to map the progression of gray and white matter atrophy over a 1-year period. Results showed that each patient group was characterized by a specific pattern of cognitive and anatomical changes. Specifically, nfvPPA patients showed gray matter atrophy progression in the left frontal and subcortical areas as well as a decline in motor speech and executive functions; svPPA patients presented atrophy progression in the medial and lateral temporal lobe and decline in semantic memory abilities; and lvPPA patients showed atrophy progression in lateral/posterior temporal and medial parietal regions with a decline in memory, sentence repetition and calculations. In addition, in all three variants, the white matter fibers underlying the abovementioned cortical areas underwent significant volume contraction over a 1-year period.
Overall, these results indicate that the three PPA variants present distinct patterns of neuroanatomical contraction, which reflect their clinical and cognitive progression. | fr |
dcterms.isPartOf | urn:ISSN:2213-1582 | fr |
dcterms.language | eng | fr |
UdeM.ReferenceFournieParDeposant | Brambati SM, Amici S, Racine C, Neuhaus J, Ogar J, Dronkers N, Miller BL, Rosen H, Gorno-Tempini ML. Longitudinal gray matter contraction in three variants of primary progressive aphasia: a tensor-based morphometry study. Neuroimage Clin 2015 Jan 22;8:345-55. doi: 10.1016/j.nicl.2015.01.011. | fr |
UdeM.VersionRioxx | Version publiée / Version of Record | fr |
oaire.citationTitle | Neurolmage | |
oaire.citationVolume | 8 | |
oaire.citationStartPage | 345 | |
oaire.citationEndPage | 355 | |