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dc.contributor.authorMascheretti, Sara
dc.contributor.authorTrezzi, Vittoria
dc.contributor.authorGiorda, Roberto
dc.contributor.authorDionne, Ginette
dc.contributor.authorPlourde, Vickie
dc.contributor.authorVitaro, Frank
dc.contributor.authorBrendgen, Mara
dc.contributor.authorBoivin, Michel
dc.contributor.authorMarino, Cecilia
dc.date.accessioned2018-09-24T15:46:43Z
dc.date.availableNO_RESTRICTIONfr
dc.date.available2018-09-24T15:46:43Z
dc.date.issued2016-08-08
dc.identifier.urihttp://hdl.handle.net/1866/20913
dc.publisherWileyfr
dc.subjectDevelopmental dyslexiafr
dc.subjectADHDfr
dc.subjectAssociation studyfr
dc.subjectGene-by-environment interactionfr
dc.subjectPleiotropyfr
dc.subjectGene-by-gene interactionfr
dc.titleComplex effects of dyslexia risk factors account for ADHD-traits : evidence from two independent samplesfr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté des arts et des sciences. École de psychoéducationfr
dc.identifier.doi10.1111/jcpp.12612
dcterms.abstractBackground: Developmental dyslexia (DD) and attention deficit/hyperactivity disorder (ADHD) are among the most common neurodevelopmental disorders, whose etiology involves multiple risk factors. DD and ADHD co-occur in the same individuals much more often than would be expected by chance. Several studies have found significant bivariate heritability, and specific genes associated with either DD or ADHD have been investigated for association in the other disorder. Moreover, there are likely to be gene-by-gene and gene-by-environment interaction effects (GxG and GxE, respectively) underlying the comorbidity between DD and ADHD. We investigated the pleiotropic effects of 19 SNPs spanning five DD genes (DYX1C1, DCDC2, KIAA0319, ROBO1 and GRIN2B) and seven DD environmental factors (smoke, miscarriage, birth weight, breastfeeding, parental age, socioeconomic status and parental education) for main, either 1) genetic or 2) environmental, 3) G×G, and 4) G×E upon inattention and hyperactivity/impulsivity. We then attempted replication of these findings in an independent twin cohort. Methods: Marker-trait association was analyzed by implementing the Quantitative Transmission Disequilibrium Test (QTDT). Environmental associations were tested by partial correlations. GxG were investigated by a general linear model equation and a family-based association test. GxE were analyzed through a general test for GxE in sib-pair-based association analysis of quantitative traits. Results: DCDC2-rs793862 was associated with hyperactivity/impulsivity via G×G (KIAA0319) and G×E (miscarriage). Smoke was significantly correlated with hyperactivity/impulsivity. We replicated the DCDC2×KIAA0319 interaction upon hyperactivity/impulsivity in the twin cohort. Conclusions: DD genetic (DCDC2) and environmental factors (smoke and miscarriage) underlie ADHD-traits supporting a potential pleiotropic effect.fr
dcterms.bibliographicCitationJournal of Child Psychology and Psychiatry ; vol. 58, no 1, p. 75-82fr
dcterms.isPartOfurn:ISSN: 0021-9630fr
dcterms.isPartOfurn:ISSN:1469-7610fr
dcterms.languageengfr
UdeM.ReferenceFournieParDeposantMascheretti, S., Trezzi, V., Giorda, R., Boivin, M., Plourde, V., Vitaro, F., Brendgen, M., Dionne, G. & Marino, C. (2017) Complex effects of dyslexia risk factors account for ADHD traits: Evidence from two independent samples. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 58(1), 75-82.fr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr


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