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dc.contributor.authorCunningham, Alexander J.
dc.contributor.authorRobinson, Mattieu
dc.contributor.authorBanquy, Xavier
dc.contributor.authorLeblond-Chain, Jeanne
dc.contributor.authorZhu, X. X.
dc.date.accessioned2018-04-25T17:39:34Z
dc.date.availableMONTHS_WITHHELD:12fr
dc.date.available2018-04-25T17:39:34Z
dc.date.issued2018-01-29
dc.identifier.citationBile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release Cunningham Alexander; Matthieu Robinson; Banquy Xavier; Chain Jeanne; Zhu Xiaoxia 15(3):1266-1276, 2018fr
dc.identifier.urihttp://hdl.handle.net/1866/19942
dc.publisherAmerican Chemical Societyfr
dc.subjectBile acidsfr
dc.subjectDoxorubicinfr
dc.subjectpH-responsivefr
dc.subjectDrug delivery systemsfr
dc.titleBile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and releasefr
dc.typeArticlefr
dc.contributor.affiliationUniversité de Montréal. Faculté de pharmaciefr
UdeM.statutProfesseur(e) / Professorfr
dc.identifier.doi10.1021/acs.molpharmaceut.7b01091
dcterms.abstractDoxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block copolymers present certain advantages over traditional polymer-based systems for drug delivery purposes, since they can enable a higher drug loading via the formation of a reservoir through their aggregation process. In this study, hydrophobic and electrostatic interactions are compared for their influence on Dox loading inside cholic acid-based block copolymers. Poly(allyl glycidyl ether) (PAGE) and poly(ethylene glycol) (PEG) were grafted from the cholic acid (CA) core yielding a star-shaped block copolymer with 4 arms (CA-(PAGE-b-PEG)4) and then loaded with Dox via a nanoprecipitation technique. A high Dox loading of 14 wt% was achieved via electrostatic as opposed to hydrophobic interactions with or without oleic acid as a cosurfactant. The electrostatic interactions confer a pH responsiveness to the system. 50% of the loaded Dox was released at pH 5 in comparison to 12% at pH 7.4. The nanoparticles with Dox loaded via hydrophobic interactions, did not show such a pH responsiveness. The systems with Dox loaded via electrostatic interactions showed the lowest IC50 and highest cellular internalization indicating the pre-eminence of this interaction in Dox loading. The blank formulations are biocompatible and did not show cytotoxicity up to 0.17 mg/mL. The new functionalized star block copolymers based on cholic acid show great potential as drug delivery carriers.fr
dcterms.bibliographicCitationMolecular Pharmaceutics ; vol. 15, no 3, p.1266–1276
dcterms.isPartOfurn:ISSN:1543-8384
dcterms.languageengfr
UdeM.VersionRioxxVersion acceptée / Accepted Manuscriptfr


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