Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release
dc.contributor.author | Cunningham, Alexander J. | |
dc.contributor.author | Robinson, Mattieu | |
dc.contributor.author | Banquy, Xavier | |
dc.contributor.author | Leblond-Chain, Jeanne | |
dc.contributor.author | Zhu, X. X. | |
dc.date.accessioned | 2018-04-25T17:39:34Z | |
dc.date.available | MONTHS_WITHHELD:12 | fr |
dc.date.available | 2018-04-25T17:39:34Z | |
dc.date.issued | 2018-01-29 | |
dc.identifier.uri | http://hdl.handle.net/1866/19942 | |
dc.publisher | American Chemical Society | fr |
dc.subject | Bile acids | fr |
dc.subject | Doxorubicin | fr |
dc.subject | pH-responsive | fr |
dc.subject | Drug delivery systems | fr |
dc.title | Bile acid-based drug delivery systems for enhanced doxorubicin encapsulation: Comparing hydrophobic and ionic interactions in drug loading and release | fr |
dc.type | Article | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de pharmacie | fr |
UdeM.statut | Professeur(e) / Professor | fr |
dc.identifier.doi | 10.1021/acs.molpharmaceut.7b01091 | |
dcterms.abstract | Doxorubicin (Dox) is a drug of choice in the design of drug delivery systems directed towards breast cancers, but is often limited by loading and control over its release from polymer micelles. Bile acid-based block copolymers present certain advantages over traditional polymer-based systems for drug delivery purposes, since they can enable a higher drug loading via the formation of a reservoir through their aggregation process. In this study, hydrophobic and electrostatic interactions are compared for their influence on Dox loading inside cholic acid-based block copolymers. Poly(allyl glycidyl ether) (PAGE) and poly(ethylene glycol) (PEG) were grafted from the cholic acid (CA) core yielding a star-shaped block copolymer with 4 arms (CA-(PAGE-b-PEG)4) and then loaded with Dox via a nanoprecipitation technique. A high Dox loading of 14 wt% was achieved via electrostatic as opposed to hydrophobic interactions with or without oleic acid as a cosurfactant. The electrostatic interactions confer a pH responsiveness to the system. 50% of the loaded Dox was released at pH 5 in comparison to 12% at pH 7.4. The nanoparticles with Dox loaded via hydrophobic interactions, did not show such a pH responsiveness. The systems with Dox loaded via electrostatic interactions showed the lowest IC50 and highest cellular internalization indicating the pre-eminence of this interaction in Dox loading. The blank formulations are biocompatible and did not show cytotoxicity up to 0.17 mg/mL. The new functionalized star block copolymers based on cholic acid show great potential as drug delivery carriers. | fr |
dcterms.isPartOf | urn:ISSN:1543-8384 | |
dcterms.language | eng | fr |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | fr |
oaire.citationTitle | Molecular pharmaceutics | |
oaire.citationVolume | 15 | |
oaire.citationIssue | 3 | |
oaire.citationStartPage | 1266 | |
oaire.citationEndPage | 1276 |
Fichier·s constituant ce document
Ce document figure dans la ou les collections suivantes
Ce document diffusé sur Papyrus est la propriété exclusive des titulaires des droits d'auteur et est protégé par la Loi sur le droit d'auteur (L.R.C. (1985), ch. C-42). Il peut être utilisé dans le cadre d'une utilisation équitable et non commerciale, à des fins d'étude privée ou de recherche, de critique ou de compte-rendu comme le prévoit la Loi. Pour toute autre utilisation, une autorisation écrite des titulaires des droits d'auteur sera nécessaire.