Browsing Titles index "Immunology and cell biology"

Now showing items 1-2 of 2

  • CD5 levels reveal distinct basal T-cell receptor signals in T cells from non-obese diabetic mice 

    Dong, Mengqi; Audiger, Cindy; Adegoke, Adeolu; Lebel, Marie-Ève; Valbon, Stefanie F; Anderson, Colin C; Melichar, Heather; Lesage, Sylvie (Wiley, 2021-02-03)
    Type 1 diabetes in non-obese diabetic (NOD) mice occurs when autoreactive T cells eliminate insulin producing pancreatic β cells. While extensively studied in T-cell receptor (TCR) transgenic mice, the contribution of alterations in thymic selection ...

  • OCA-B does not act as a transcriptional coactivator in T cells 

    Lombard-Vadnais, Félix; Lacombe, Julie; Chabot-Roy, Geneviève; Ferron, Mathieu; Lesage, Sylvie (Wiley, 2022-05-01)
    Pou2af1 encodes for OCA-B, a coactivator of OCT-1/2 transcription factors, which plays a key role in B-cell maturation. The function of OCA-B has also been studied in T cells, where T cells from Pou2af1−/− mice have impaired functions, such as cytokine ...