Browsing Faculté de médecine – Travaux et publications by Author "Allain, Florence"
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Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats
Servonnet, Alice; Allain, Florence; Gravel-Chouinard, Alice; Hernandez, Giovanni; Bourdeau Caporuscio, Casey; Legrix, Mathilde; Lévesque, Daniel; Rompré, Pierre-Paul; Samaha, Anne-Noël (Elsevier, 2021-08-05)Antipsychotic treatment can produce a dopamine-supersensitive state, potentiating the response to dopamine receptor stimulation. In both schizophrenia patients and rats, this is linked to tolerance to ongoing antipsychotic treatment. In rodents, dopamine ... -
How fast and how often: the pharmacokinetics of drug use are decisive in addiction
Allain, Florence; Minogianis, Ellie-Anna; Roberts, David C.S.; Samaha, Anne-Noël (2015-09)How much, how often and how fast a drug reaches the brain determine the behavioural and neuroplastic changes associated with the addiction process. Despite the critical nature of these variables, the drug addiction field often ignores pharmacokinetic ...