Browsing Faculté de médecine – Travaux et publications by Author "Allain, Florence"

Now showing items 1-2 of 2

  • Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats 

    Servonnet, Alice; Allain, Florence; Gravel-Chouinard, Alice; Hernandez, Giovanni; Bourdeau Caporuscio, Casey; Legrix, Mathilde; Lévesque, Daniel; Rompré, Pierre-Paul; Samaha, Anne-Noël (Elsevier, 2021-08-05)
    Antipsychotic treatment can produce a dopamine-supersensitive state, potentiating the response to dopamine receptor stimulation. In both schizophrenia patients and rats, this is linked to tolerance to ongoing antipsychotic treatment. In rodents, dopamine ...

  • How fast and how often: the pharmacokinetics of drug use are decisive in addiction 

    Allain, Florence; Minogianis, Ellie-Anna; Roberts, David C.S.; Samaha, Anne-Noël (2015-09)
    How much, how often and how fast a drug reaches the brain determine the behavioural and neuroplastic changes associated with the addiction process. Despite the critical nature of these variables, the drug addiction field often ignores pharmacokinetic ...