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  • Bisphosphoglycerate mutase deficiency protects against cerebral malaria and severe malaria-induced anemia 

    Xu, Guoyue; Van Bruggen, Rebekah; Gualtieri, Christian O.; Moradin, Neda; Fois, Adrien; Vallerand, Diane; De Sa Tavares Russo, Mariana; Bassenden, Angelia; Lu, Wenyun; Tam, Mifong; Lesage, Sylvie; Girouard, Hélène; Avizonis, Daina Zofija; Deblois, Geneviève; Prchal, Josef T.; Stevenson, Mary; Berghuis, Albert; Muir, Tom; Rabinowitz, Joshua; Vidal, Silvia M.; Fodil, Nassima; Gros, Philippe (Cell Press, 2020-09-22)
    The replication cycle and pathogenesis of the Plasmodium malarial parasite involves rapid expansion in red blood cells (RBCs), and variants of certain RBC-specific proteins protect against malaria in humans. In RBCs, bisphosphoglycerate mutase (BPGM) ...