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Vascular injury derived apoptotic exosome-like vesicles trigger autoimmunity
(Elsevier, 2024-08-11)According to a central tenet of classical immune theory, a healthy immune system must avoid self-reactive lymphocyte clones but we now know that B cells repertoire exhibit some level of autoreactivity. These autoreactive B cells are thought to rely on ... -
Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines
(Springer Nature, 2024-07-29)Targeted therapeutics for high-risk cancers remains an unmet medical need. Here we report the results of a large-scale screen of over 11,000 molecules for their ability to inhibit the survival and growth in vitro of human leukemic cells from multiple ... -
Decreased progenitor TCF1 + T-cells correlate with COVID-19 disease severity
(Nature research, 2024-05-03)COVID-19, caused by SARS-CoV-2, can lead to a severe inflammatory disease characterized by significant lymphopenia. However, the underlying cause for the depletion of T-cells in COVID-19 patients remains incompletely understood. In this study, we ... -
Excessive intragastric alcohol administration exacerbates hepatic encephalopathy and provokes neuronal cell death in male rats with chronic liver disease
(Wiley, 2024-04-29)Hepatic encephalopathy (HE) is defined as decline in neurological function during chronic liver disease (CLD). Alcohol is a major etiological factor in the pathogenesis of fibrosis/cirrhosis and has also been documented to directly impact the brain. ... -
Conservative management for urinary incontinence in neurological patients : A systematic review and meta-analysis
(Elsevier, 2024-04-11)Abstract Aim: To summarize evidence from a search and review of the 7th International Consultation on Incontinence chapter’s section on conservative treatments in neurological patients. Methods: Searching the Cochrane Incontinence Specialised ... -
In silico human cardiomyocyte action potential modeling : exploring ion channel input combinations
(SAGE, 2024-03-13)In silico modeling offers an opportunity to supplement and accelerate cardiac safety testing. With in silico modeling, computational simulation methods are used to predict electrophysiological interactions and pharmacological effects of novel drugs on ... -
Finite element model of the shoulder with active rotator cuff muscles : application to wheelchair propulsion
(Springer, 2024-02-20)Purpose: The rotator cuff is prone to injury, remarkably so for manual wheelchair users. To understand its pathomechanisms, finite element models incorporating threedimensional activated muscles are needed to predict soft tissue strains during ... -
Enjeux et défis de la prise en charge du bruit ferroviaire en aménagement et en urbanisme : un guide d’orientation
(2024-02-19)Cet ouvrage vise à sensibiliser les divers intervenants quant aux tenants et aboutissants de l’environnement sonore, en particulier à ce qui a trait au bruit ferroviaire, et aux enjeux de sa prise en charge en aménagement. Empruntant la forme d’un ... -
Assessment of involuntary PFM contractions in comparison with existing literature and IUGA/ICS terminology reports
(Springer, 2024-02-08)Introduction and Hypothesis Involuntary pelvic floor muscle (PFM) contractions are thought to occur during an increase in intra-abdominal pressure (IAP). Although no studies have assessed their presence in women with normal pelvic floor (PF) function, ... -
PD-1 endocytosis unleashes the cytolytic potential of check-point blockade in tumor immunity
(2024)PD-1 immune checkpoint blockade (ICB) is now a promising first-line treatment for many cancers. While the steric blockade of PD-1 binding to its ligand plays a role, the role of internalisation in promoting the efficacy of ICB has not been explored. ... -
Trunk and glenohumeral joint adaptations to manual wheelchair propulsion over a cross-slope : an exploratory study
(Elsevier, 2023-12-31)Background: Cross-slopes are often encountered by manual wheelchair users propelling within an urban setting. While propulsion over cross-slopes is more difficult than on level surfaces, little is known about how the users counter the downhill turning ... -
Exploring spoken discourse and its neural correlates in women with Alzheimer's disease with low levels of education and socioeconomic status
(American Speech-Language-Hearing Association, 2023-12-29)Purpose: Early impairments in spoken discourse abilities have been identified in Alzheimer's disease (AD). However, the impact of AD on spoken discourse and the associated neuroanatomical correlates have mainly been studied in populations with higher ... -
Number agreement processing in adolescents with and without developmental language disorder (DLD) : evidence from event-related brain potentials
(Nature research, 2023-12-21)In morphologically richer languages, including French, one must learn the specific properties of number agreement in order to understand the language, and this learning process continues into adolescence. This study examined similarities and differences ... -
Individual participant data meta-analysis of LR-5 in LI-RADS version 2018 versus revised LI-RADS for hepatocellular carcinoma diagnosis
(Radiological Society of North America, 2023-12-19)Background A simplification of the Liver Imaging Reporting and Data System (LI-RADS) version 2018 (v2018), revised LI-RADS (rLI-RADS), has been proposed for imaging-based diagnosis of hepatocellular carcinoma (HCC). Single-site data suggest that ... -
Cavus foot in soccer players : increased prevalence in experienced players and risk factor for injury
(American Podiatric Medical Association, 2023-11)Background: Foot type, especially cavus foot, is associated with foot and ankle soccer injuries, such as ankle sprains, ankle instability, and foot and ankle lateral injuries. The aim of this study was to identify risk factors for foot and ankle ... -
COOK technology to support meal preparation following a severe traumatic brain injury : a usability mixed-methods single-case study in a real-world environment
(Taylor and Francis, 2023-10-13)Introduction Following a traumatic brain injury (TBI), meal preparation may become challenging as it involves multiple cognitive abilities and sub-tasks. To support this population, the Cognitive Orthosis for coOKing (COOK) was developed in partnership ... -
Adaptation and reliability of the Cinderella story retell task in Canadian French persons without brain injury
(American Speech-Language-Hearing Association, 2023-09-27)Purpose: Main concept (MC) analysis is a well-documented method of discourse analysis in adults with and without brain injury. This study aims to develop a MC checklist that is culturally and linguistically adapted for Canadian French speakers and ...