Browsing Faculté de médecine – Travaux et publications by Author "Imagen Consortium"
Now showing items 1-9 of 9
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Association of protein phosphatase PPM1G with alcohol use disorder and brain activity during behavioral control in a genome-wide methylation analysis
(American Psychiatric Publishing, 2015-06)OBJECTIVE: The genetic component of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonheritable differences that could be mediated by epigenetics. Despite growing evidence associating epigenetics and psychiatric ... -
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
(Nature Research, 2017-02-21)Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability ... -
Cannabis use in early adolescence: evidence of amygdala hypersensitivity to signals of threat
(Elsevier, 2015-12)Cannabis use in adolescence may be characterized by differences in the neural basis of affective processing. In this study, we used an fMRI affective face processing task to compare a large group (n = 70) of 14-year olds with a history of cannabis use ... -
Correlated gene expression supports synchronous activity in brain networks
(American Association for the Advancement of Science, 2015-06-12)During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional ... -
ENIGMA and the individual : Predicting factors that affect the brain in 35 countries worldwide
(Elsevier, 2017-01-15)In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) – a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. ... -
Genomic architecture of human neuroanatomical diversity
(Nature Publishing Group, 2015-08)Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently ... -
Personality, attentional biases towards emotional faces and symptoms of mental disorders in an adolescent sample
(Public Library of Science, 2015-06-05)Objective To investigate the role of personality factors and attentional biases towards emotional faces, in establishing concurrent and prospective risk for mental disorder diagnosis in adolescence. Method Data were obtained as part of the IMAGEN study, ... -
Sleep habits, academic performance, and the adolescent brain structure
(Nature Research, 2017-02-09)Here we report the first and most robust evidence about how sleep habits are associated with regional brain grey matter volumes and school grade average in early adolescence. Shorter time in bed during weekdays, and later weekend sleeping hours correlate ... -
The structure of psychopathology in adolescence and its common personality and cognitive correlates
(American Psychological Association, 2016-11)The traditional view that mental disorders are distinct, categorical disorders has been challenged by evidence that disorders are highly comorbid and exist on a continuum (e.g., Caspi et al., 2014; Tackett et al., 2013). The first objective of this ...
