Single and Multiple Domain Amnestic MCI: two sides of the same coin?
Single- and multiple-domain amnestic mild cognitive impairment: two sides of the same coin?
Article [Accepted Manuscript]
Abstract(s)
Background. Amnestic Mild Cognitive Impairment (aMCI) is considered a transition
stage between normal aging and Alzheimer's disease (AD). Two main clinical subtypes
of aMCI have been identified: 1) aMCI single domain (aMCI-SD), with isolated episodic
memory impairments, and 2) aMCI multiple domain (aMCI-MD), with episodic memory
impairments and deficits in one or more other cognitive domains.
Aims.To map the pattern of gray matter (GM) atrophy associated with aMCI-SD, aMCIMD
and mild AD.
Methods. A group of aMCI-SD, aMCI-MD characterized by executive function disorders,
mild AD patients and cognitively unimpaired age-matched subjects underwent a
comprehensive neuropsychological assessment and a high-definition MR brain scan.
Voxel-based morphometry (VBM) analysis was used to characterize the GM tissue loss
in each patient group, and the common pattern of GM atrophy in aMCI-SD and aMCIMD.
Results. The results revealed that aMCI-SD and aMCI-MD are characterized by a
common pattern of GM atrophy within the medial temporal cortex, predisposing to AD
and correlating with the severity of verbal memory symptoms. Moreover, the pattern of
GM atrophy observed in aMCI-SD, aMCI-MD and mild AD revealed that, from an
anatomical point of view, these three clinical syndromes could represent three severity
points along the continuum between normal aging and AD.
Other location(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.