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Clinical, anatomical and pathological features in the three variants of primary progressive aphasia : a review
(Frontiers media, 2018-08-21)
Primary progressive aphasias (PPA) are neurodegenerative diseases clinically
characterized by an early and relatively isolated language impairment. Three main
clinical variants, namely the nonfluent/agrammatic variant ...
Deformation-based shape analysis of the hippocampus in the semantic variant of primary progressive aphasia and Alzheimer’s disease
(Elsevier, 2020-06-03)
Background
Increasing evidence shows that the semantic variant of primary progressive aphasia (svPPA) is characterized by hippocampal atrophy. However, less is known about disease-related morphological hippocampal changes. ...
Connected speech markers of amyloid burden in primary progressive aphasia
(Elsevier, 2021-10-07)
INTRODUCTION
Positron emission tomography (PET) amyloid imaging has become an important part of the diagnostic workup for patients with primary progressive aphasia (PPA) and uncertain underlying pathology. Here, we employ ...
The anatomy of category-specific object naming in neurodegenerative diseases
(Massachusetts Institute of Technology Press, 2006)
Neuropsychological studies suggest that knowledge about
living and nonliving objects is processed in separate brain regions. However, lesion and functional neuroimaging studies
have implicated different areas. To address ...
Music recognition in frontotemporal lobar degeneration and Alzheimer disease
(Lippincott, Williams & Wilkins, 2011-06)
Objective—To compare music recognition in patients with frontotemporal dementia, semantic
dementia, Alzheimer disease, and controls and to evaluate the relationship between music
recognition and brain volume.
Backgrou ...
Longitudinal gray matter contraction in three variants of primary progressive aphasia : a tensor-based morphometry study
(Elsevier, 2015-01-22)
The present study investigated the pattern of longitudinal changes in cognition and anatomy in three variants of primary progressive aphasia (PPA). Eight patients with the non-fluent variant of PPA (nfvPPA), 13 patients ...
The neural correlates of verbal and nonverbal semantic processing deficits in neurodegenerative disease
(Lippincott, Williams & Wilkins, 2009)
Objective—To investigate the neural correlates of verbal and non-verbal semantic processing in
neurodegenerative disease.
Background—Semantic memory is often impaired in neurodegenerative disease.
Neuropsychological and ...
The logopenic/phonological variant of primary progressive aphasia
(American Academy of Neurology, 2008)
Objective: Primary progressive aphasia (PPA) is characterized by isolated decline in language
functions. Semantic dementia and progressive nonfluent aphasia are accepted PPA variants. A
“logopenic” variant (LPA) has also ...
Anatomical correlates of early mutism in progressive nonfluent aphasia
(American Academy of Neurology, 2006)
Patients with progressive nonfluent aphasia (PNFA) can become
mute early in the course of the disease. Voxel-based morphometry showed that
PNFA is associated with left anterior insula and inferior frontal atrophy. In
...