Browsing Faculté des arts et des sciences – Département de psychologie - Travaux et publications by Author "Chertkow, Howard"
Now showing items 1-4 of 4
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Amyloid burden and white matter hyperintensities mediate age-related cognitive differences
Sévigny Dupont, Pénélope; Bocti, Christian; Joannette, Maude; Lavallée, Marie Maxime; Nikelski, Jim; Vallet, Guillaume; Chertkow, Howard; Joubert, Sven (Elsevier, 2019-08)This study examined the additive versus synergistic contribution of beta-amyloid (Aβ) and white matter hyperintensities (WMHs) across 7 cognitive domains in 104 cognitively normal older adults. It also measured the extent to which age-related differences ... -
Education as a moderator of the relationship between episodic memory and amyloid load in normal aging
Joannette, Maude; Bocti, Christian; Sévigny Dupont, Pénélope; Lavallée, Marie Maxime; Nikelski, Jim; Vallet, Guillaume; Chertkow, Howard; Joubert, Sven (Oxford University Press, 2019-10-23)The current study explored whether education, a proxy of cognitive reserve, modifies the association between episodic memory (EM) performance and βeta-amyloid load (Aβ), a biomarker of Alzheimer’s disease, in a cohort of cognitively normal older ... -
Subcortical amyloid load is associated with shape and volume in cognitively normal individuals
Subcortical Aβ associates to morphometry
Rahayel, Shady; Bocti, Christian; Sévigny Dupont, Pénélope; Joannette, Maude; Lavallée, Marie Maxime; Nikelski, Jim; Chertkow, Howard; Joubert, Sven (Wiley, 2019-05-21)Amyloid-beta (Aβ) deposition is one of the main hallmarks of Alzheimer’s disease. The study assessed the associations between cortical and subcortical 11C-Pittsburgh Compound B retention, namely in the hippocampus, amygdala, putamen, caudate, pallidum, ... -
Subcortical amyloid relates to cortical morphology in cognitively normal individuals
Rahayel, Shady; Bocti, Christian; Sévigny Dupont, Pénélope; Joannette, Maude; Lavallée, Marie Maxime; Nikelski, Jim; Chertkow, Howard; Joubert, Sven (Springer, 2019-07-25)Purpose Amyloid (Aβ) brain deposition can occur in cognitively normal individuals and is associated with cortical volume abnormalities. Aβ-related volume changes are inconsistent across studies. Since volume is composed of surface area and thickness, ...