Faculté de pharmacie – Travaux et publications: Recent submissions
Now showing items 61-70 of 95
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Platelet function tests
(Thieme Publishing, 2016-04)Traditionally developed for diagnosis of bleeding disorders, platelet function assays have become increasingly used in basic research on platelet physiology, in phenotype-genotype associations in bleeding disorders, in drug development as surrogate ... -
Increased platelet reactivity and platelet–leukocyte aggregation after elective coronary bypass surgery
(Taylor & Francis, 2018-11-13)Inflammatory mechanisms are activated, and thrombotic complications occur during the initial months after coronary artery bypass grafting (CABG). Therefore, changes over time of platelet activation and platelet–leukocyte interactions after CABG are ... -
Nanoparticle heterogeneity : an emerging structural parameter 2 influencing particle fate in biological media?
(Royal Society of Chemistry, 2018-11-27)Drug nanocarriers’ surface chemistry is often presumed to be uniform. For instance, the polymer surface coverage and distribution of ligands on nanoparticles are described with averaged values obtained from quantification techniques based on particle ... -
Platelet function in aging
(Frontiers Media, 2019-08-07)Aging is associated with an increased incidence of cardiovascular disease and thrombosis. Platelets play a major role in maintaining hemostasis and in thrombus formation, making them a key player in thrombotic disorders. Whereas it is well-known that ... -
Lubrication and wear protection of micro-structured hydrogels using bioinspired fluids
(American Chemical Society, 2018-11-21)We report the fabrication and the use of a bioinspired synovial fluid acting as a lubricant fluid and anti-wear agent at soft and porous chitosan hydrogel tribopairs. This synthetic synovial fluid is composed of sodium hyaluronate (HA) and a bottle-brush ... -
Effect of surface chemistry of polymeric nanoparticles on cutaneous penetration of cholecalciferol
(Elsevier, 2018-10-11)We investigated the influence of nanoparticle (NP) surface composition on different aspects of skin delivery of a lipophilic drug: chemical stability, release and skin penetration. Cholecalciferol was chosen as a labile model drug. Poly(lactic acid) ... -
Biomimetic bottle-brush polymer coatings for fabrication of ultra-low fouling surfaces
(Wiley, 2018-11-13)The increasing demand for long lasting antifouling surfaces has steered the development of accessible, novel, biocompatible and environmentally-friendly materials. Inspired by lubricin (LUB), a component of mammalian synovial fluid with excellent ... -
Clinical importance of thrombocytopenia in patients with acute coronary syndromes : a systematic review and meta-analysis
Thrombocytopenia in acute coronary syndromes
(Taylor & Francis, 2018-10-22)Thrombocytopenia (TP) is common in hospitalized patients. In the context of acute coronary syndromes (ACS), TP has been linked to adverse clinical outcomes. We present a systematic review and meta-analysis of the evidence on the clinical importance of ... -
Preparedness for the next epidemic : health and political issues of an emerging paradigm
(Taylor & Francis, 2018-03-08)‘Preparing for the next epidemic’ has been a recurrent theme in global health in recent years. Starting with SARS, by way of the Avian influenza, and intensifying after the 2013–2016 Ebola outbreak, the urgency of preparing for the next health ...
