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Postoperative administration of the acetylcholinesterase inhibitor, donepezil, interferes with bone healing and implant osseointegration in a rat model
(MDPI, 2020-09-14)
Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative ...
Platelets selectively regulate the release of BDNF, but not that of its precursor protein, proBDNF
(Frontiers Media, 2020-11-25)
Background: Brain-derived neurotrophic factor (BDNF) plays a role in synaptic plasticity and neuroprotection. BDNF has well-established pro-survival effects, whereas its precursor protein, proBDNF, induces apoptosis. Thus, ...
Modeling treatment effect modification in multidrug-resistant tuberculosis in an individual patient data meta-analysis
(SAGE, 2021)
Effect modification occurs while the effect of the treatment is not homogeneous across the different strata of patient characteristics. When the effect of treatment may vary from individual to individual, precision medicine ...
The brain-derived neurotrophic factor prompts platelet aggregation and secretion
(American Society of Hematology, 2021-09-21)
Brain-derived neurotrophic factor (BDNF) has both autocrine and paracrine roles in
neurons, and its release and signaling mechanisms have been extensively studied in the
central nervous system. Large quantities of BDNF ...
Platelet quiescence in patients with acute coronary syndrome undergoing coronary artery bypass graft surgery
(Wiley, 2021)
BACKGROUND: The optimal antiplatelet strategy for patients with acute coronary syndromes who require coronary artery
bypass surgery remains unclear. While a more potent antiplatelet regimen will predispose to perioperative ...
A tutorial on dealing with time‐varying eligibility for treatment: Comparing the risk of major bleeding with direct‐acting oral anticoagulants vs warfarin
(Wiley, 2020-08-18)
In this tutorial, we focus on the problem of how to define and estimate treatment
effects when some patients develop a contraindication and are thus ineligible to receive
a treatment of interest during follow-up. We first ...
Advances in platelet function testing—light transmission aggregometry and beyond
(MDPI, 2020-08-13)
Platelet function testing is essential for the diagnosis of hemostasis disorders. While there
are many methods used to test platelet function for research purposes, standardization is often
lacking, limiting their use ...
Start small : how nanomedicine could alleviate the burden of rare CNS Diseases
(MDPI, 2021-01-30)
The complexity and organization of the central nervous system (CNS) is widely modulated by the presence of the blood–brain barrier (BBB) and the blood–cerebrospinal fluid barrier
(BCSFB), which both act as biochemical, ...
Impact of discretization of the timeline for longitudinal causal inference methods
(Wiley, 2020-09-01)
In longitudinal settings, causal inference methods usually rely on a
discretization of the patient timeline that may not reflect the underlying data generation process. This paper investigates the estimation of
causal ...
Tissue-specificity of antibodies raised against TrkB and p75NTR receptors ; implications for platelets as models of neurodegenerative diseases
(Frontiers media, 2021-02-11)
Platelets and neurons share many similarities including comparable secretory granule
types with homologous calcium-dependent secretory mechanisms as well as
internalization, sequestration and secretion of many ...