Browsing Faculté de médecine vétérinaire – Travaux et publications by Author "Gagnon, Carl A."
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Actinobacillus pleuropneumoniae (App) culture supernatant antiviral effect against porcine reproductive and respiratory syndrome virus (PRRSV) occurs prior to the viral genome replication and transcription through actin depolymerization
Hernandez Reyes, Yenney; Provost, Chantale; Kist Traesel, Carolina; Jacques, Mario; Gagnon, Carl A. (Microbiology Society, 2018-01-02)PURPOSE: Recently, the strong antiviral activity of an Actinobacillus pleuropneumoniae (App) culture supernatant against porcine reproductive and respiratory syndrome virus (PRRSV) was discovered. Following this finding, the objective of the present ... -
Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication
Ferreira Barbosa, Jérémy A.; Labrie, Josée; Beaudry, Francis; Gagnon, Carl A.; Jacques, Mario (2015-12)Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available. We recently ... -
Actinobacillus pleuropneumoniae Possesses an Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus
Lévesque, Cynthia; Provost, Chantale; Labrie, Josée; Hernandez Reyes, Yenney; Burciaga Nava, Jorge A.; Gagnon, Carl A.; Jacques, Mario (2014-05)Pigs are often colonized by more than one bacterial and/or viral species during respiratory tract infections. This phenomenon is known as the porcine respiratory disease complex (PRDC). Actinobacillus pleuropneumoniae (App) and porcine reproductive ... -
The administration of diets contaminated with low to intermediate doses of deoxynivalenol and supplemented with antioxidants and binding agents slightly affects the growth, antioxidant status and vaccine response in weanling pigs
Lo Verso, Luca; Dumont, Kristina; Lessard, Martin; Lauzon, Karoline; Provost, Chantale; Gagnon, Carl A.; Chorfi, Younès; Guay, Frédéric (Oxford University Press, 2021-08-18)This study aimed to evaluate the impact of grading levels of deoxynivalenol (DON) in the diet of weaned pigs, as well as the effects of a supplementation with antioxidants (AOX), hydrated sodium calcium aluminosilicates (HSCAS) and their combination ... -
Alternative codon usage of PRRS virus ORF5 gene increases eucaryotic expression of GP5 glycoprotein and improves immune response in challenged pigs
Kheyar, Ali; Jabrane, Ahmed; Zhu, Chengru; Cléroux, Patrick; Massie, Bernard; Dea, Serge; Gagnon, Carl A. (2005-07)Pigs exposed to GP5 protein of PRRSV by means of DNA immunization develop specific neutralizing and protecting antibodies. Herein, we report on the consequences of codon bias, and on the favorable outcome of the systematic replacement of native codons ... -
Analysis of whole-genome sequences of infectious laryngotracheitis virus isolates from poultry flocks in Canada : evidence of recombination
Perez-Contreras, Ana; Checkley, Sylvia; Van der Meer, Frank; Joseph, Tomy; King, Robin; Ravi, Madhu; Peters, Delores; Fonseca, Kevin; Gagnon, Carl A.; Provost, Chantale; Ojkic, Davor; Abdul-Careem, Mohamed Faizal (MDPI, 2020-11-12)Infectious laryngotracheitis virus (ILTV) is a herpes virus that causes an acute respiratory disease of poultry known as infectious laryngotracheitis (ILT). Chicken embryo origin (CEO) and tissue culture origin (TCO) live attenuated vaccines are routinely ... -
Bilan 2020 : identification des pathogènes aviaires au Québec grâce à l’utilisation de tests moléculaires
Gagnon, Carl A.; Fairbrother, John Morris; Lair, Stéphane (Ordre des médecins vétérinaires du Québec, 2021) -
Bird species involved in west nile virus epidemiological cycle in southern Québec
Taieb, Ludivine; Ludwig, Antoinette; Ogden, Nicholas; Lindsay, Robbin L.; Iranpour, Mahmood; Gagnon, Carl A.; Bicout, Dominique J. (MDPI, 2020-06-23)Despite many studies on West Nile Virus (WNV) in the US, including the reservoir role of bird species and the summer shifts of the Culex mosquito, feeding from birds to mammals, there have been few equivalent studies in the neighboring regions of ... -
Canine parvovirus type 2b is the most prevalent genomic variant strain found in parvovirus antigen positive diarrheic dog feces samples across Canada
Gagnon, Carl A.; Allard, Véronique; Cloutier, Guillaume (2016-01) -
Capsular sialic acid of Streptococcus suis serotype 2 binds to swine influenza virus and enhances bacterial interactions with virus-infected tracheal epithelial cells
Wang, Yingchao; Gagnon, Carl A.; Savard, Christian; Music, Nedzad; Srednik, Mariela; Segura, Mariela; Lachance, Claude; Bellehumeur, Christian; Gottschalk, Marcelo (2013-12)Streptococcus suis serotype 2 is an important swine bacterial pathogen, and it is also an emerging zoonotic agent. It is unknown how S. suis virulent strains, which are usually found in low quantities in pig tonsils, manage to cross the first host ... -
Case Report: Esophagitis and pharyngitis associated with avian infectious laryngotracheitis in backyard chickens: 2 cases
Sary, Kathleen; Chénier, Sonia; Gagnon, Carl A.; Shivaprasad, H. L.; Sylvestre, Doris; Boulianne, Martine (2017-06)Infectious laryngotracheitis (ILT) is a contagious viral respiratory disease of great economic importance for the global poultry industry caused by Gallid herpesvirus 1 (GaHV-1). Lesions of the upper digestive tract caused by this virus have not been ... -
Characterization of a Canadian mink H3N2 influenza A virus isolate genetically related to triple reassortant swine influenza virus
Gagnon, Carl A.; Spearman, Grant; Hamel, Andre; Godson, Dale L.; Fortin, Audrey; Fontaine, Guy; Tremblay, Donald (2009-03)In 2007, an H3N2 influenza A virus was isolated from Canadian mink. This virus was found to be phylogenetically related to a triple reassortant influenza virus which emerged in Canadian swine in 2005, but it is antigenically distinct. The transmission ... -
Chicken astrovirus (CAstV) molecular studies reveal evidence of multiple past recombination events in sequences originated from clinical samples of white chick syndrome (WCS) in Western Canada
Palomino-Tapia, Victor A.; Mitevski, Darko; Inglis, Tom; Van der Meer, Frank; Martin, Emily; Brash, Marina; Provost, Chantale; Gagnon, Carl A.; Abdul-Careem, Mohamed Faizal (MDPI, 2020-09-28)In this study, we aimed to molecularly characterize 14 whole genome sequences of chicken astrovirus (CAstV) isolated from samples obtained from white chick syndrome (WCS) outbreaks in Western Canada during the period of 2014–2019. Genome sequence ... -
Coding-complete genome sequence of a Falcon aviadenovirus A strain associated with necrotizing hepatitis in an American Kestrel (Falco sparverius)
Gagnon, Carl A.; Provost, Chantale; Lair, Stéphane (American Society for Microbiology, 2022-03-17)A necropsy was performed on an American kestrel (Falco sparverius) with necrotizing hepatitis associated with inclusion bodies, suggesting an adenovirus infection. A next-generation sequencing assay was conducted on the liver, and the coding-complete ... -
Coinfections and their molecular consequences in the porcine respiratory tract
Saade, Georges; Deblanc, Céline; Bougon, Juliette; Marois-Créhan, Corinne; Fablet, Christelle; Auray, Gaël; Belloc, Catherine; Leblanc‑Maridor, Mily; Gagnon, Carl A.; Zhu, Jianzhong; Gottschalk, Marcelo; Summerfeld, Artur; Simon, Gaëlle; Meurens, François; Bertho, Nicolas (BMC, 2020-06-16)Understudied, coinfections are more frequent in pig farms than single infections. In pigs, the term “Porcine Respiratory Disease Complex” (PRDC) is often used to describe coinfections involving viruses such as swine Influenza A Virus (swIAV), Porcine ... -
Comparative full genome sequence analysis of wild-type and chicken embryo origin vaccine-like infectious laryngotracheitis virus field isolates from Canada
Elshafiee, Esraa A.; Hassan, Mohamed S.H.; Provost, Chantale; Gagnon, Carl A.; Ojkic, Davor; Abdul-Careem, Mohamed Faizal (Elsevier, 2022-08-14)Infectious laryngotracheitis (ILT), caused by infectious laryngotracheitis virus (ILTV), occurs sporadically in poultry flocks in Canada. Live attenuated chicken embryo origin (CEO) vaccines are being used routinely to prevent and control ILTV infections. ... -
Comparison of primary virus isolation in pulmonary alveolar macrophages and four different continuous cell lines for type 1 and type 2 porcine reproductive and respiratory syndrome virus
Xie, Jiexiong; Vereecke, Nick; Theuns, Sebastiaan; Oh, Dayoung; Vanderheijden, Nathalie; Trus, Ivan; Sauer, Jannes; Vyt, Philip; Bonckaert, Caroline; Lalonde, Christian; Provost, Chantale; Gagnon, Carl A.; Nauwynck, Hans (MDPI, 2021-06-03)Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) has a highly restricted cellular tropism. In vivo, the virus primarily infects tissue-specific macrophages in the nose, lungs, tonsils, and pharyngeal lymphoid tissues. In vitro however, the ... -
Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine
Savard, Christian; Gagnon, Carl A.; Chorfi, Younès (2015-07-31)Cereal commodities are frequently contaminated with mycotoxins produced by the secondary metabolism of fungal infection. Among these contaminants, deoxynivalenol (DON), also known as vomitoxin, is the most prevalent type B trichothecene mycotoxin ... -
Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of Porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey
Gagnon, Carl A.; Del Castillo, Jérôme; Music, Nedzad; Fontaine, Guy; Harel, Josée; Tremblay, Donald (2008-09)By the end of 2004, the Canadian swine population had experienced a severe 2 increase in the incidence of Porcine circovirus-associated disease (PCVAD), a problem that was 3 associated with the emergence of a new Porcine circovirus-2 genotype (PCV-2b), ... -
Distinct miRNA profile of cellular and extracellular vesicles released from chicken tracheal cells following avian influenza virus infection
O’Dowd, Kelsey; Emam, Mehdi; El Khili, Mohamed Reda; Emad, Amin; Ibeagha-Awemu, Eveline M.; Gagnon, Carl A.; Barjesteh, Neda (MDPI, 2020-08-05)Innate responses provide the first line of defense against viral infections, including the influenza virus at mucosal surfaces. Communication and interaction between different host cells at the early stage of viral infections determine the quality ...