Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure
dc.contributor.author | Chatauret, Nicolas | |
dc.contributor.author | Rose, Christopher | |
dc.contributor.author | Therrien, Guy | |
dc.contributor.author | Butterworth, Roger | |
dc.date.accessioned | 2013-04-25T20:57:24Z | |
dc.date.available | 2013-04-25T20:57:24Z | |
dc.date.issued | 2001-06 | |
dc.identifier.uri | http://hdl.handle.net/1866/9592 | |
dc.description.sponsorship | CIHR | en |
dc.subject | Acide lactique | en |
dc.subject | Acute liver failure | en |
dc.subject | Brain edema | en |
dc.subject | Brain energy metabolism | en |
dc.subject | Défaillance hépatique aigüe | en |
dc.subject | Encéphalopathie hépatique | en |
dc.subject | Hepatic encephalopathy | en |
dc.subject | Hypothermia | en |
dc.subject | Hypothermie | en |
dc.subject | Lactate | en |
dc.subject | Oedème cérébral | en |
dc.title | Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure | |
dc.type | Article | en |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Centre de recherche du CHUM | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine | fr |
dc.identifier.doi | 10.1023/A:1011622830569 | |
dcterms.abstract | Evidence from both clinical and experimental studies demonstrates that mild hypothermia prevents encephalopathy and brain edema in acute liver failure (ALF). As part of a series of studies to elucidate the mechanism(s) involved in this protective effect, groups of rats with ALF resulting from hepatic devascularization were maintained at either 37°C (normothermic) or 35°C (hypothermic), and neurological status was monitored in relation to cerebrospinal fluid (CSF) concentrations of ammonia and lactate. CSF was removed via implanted cisterna magna catheters. Mild hypothermia resulted in a delay in onset of encephalopathy and prevention of brain edema; CSF concentrations of ammonia and lactate were concomitantly decreased. Blood ammonia concentrations, on the other hand, were not affected by hypothermia in ALF rats. These findings suggest that brain edema and encephalopathy in ALF are the consequence of ammonia-induced impairment of brain energy metabolism and open the way for magnetic resonance spectroscopic monitoring of cerebral function in ALF. Mild hypothermia could be beneficial in the prevention of severe encephalopathy and brain edema in patients with ALF awaiting liver transplantation. | en |
dcterms.language | eng | en |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Metabolic brain disease | |
oaire.citationVolume | 16 | |
oaire.citationIssue | 43832 | |
oaire.citationStartPage | 95 | |
oaire.citationEndPage | 102 |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.