Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis
dc.contributor.author | Desjardins, Paul | |
dc.contributor.author | Sauvageau, Anny | |
dc.contributor.author | Bouthillier, Alain | |
dc.contributor.author | Navarro, Darren | |
dc.contributor.author | Hazell, Alan S. | |
dc.contributor.author | Rose, Christopher | |
dc.contributor.author | Butterworth, Roger | |
dc.date.accessioned | 2013-04-25T19:01:42Z | |
dc.date.available | 2013-04-25T19:01:42Z | |
dc.date.issued | 2003 | |
dc.identifier.uri | http://hdl.handle.net/1866/9586 | |
dc.subject | Astrocytes | en |
dc.subject | Cyclooxygenase 2 | en |
dc.subject | Épilepsie temporale | en |
dc.subject | Prostaglandines | en |
dc.subject | Prostaglandins | en |
dc.subject | Temporal lobe epilepsy | en |
dc.title | Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis | |
dc.type | Article | en |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Centre de recherche du CHUM | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine | fr |
dc.identifier.doi | 10.1016/S0197-0186(02)00101-8 | |
dcterms.abstract | Induction of cyclooxygenase-2 (COX-2) has been described in a wide range of neurological diseases including animal models of epilepsy. The present study was undertaken to assess COX-2 expression in hippocampal biopsies from patients with therapy-refractive temporal lobe epilepsy (TLE). For this purpose, hippocampal CA1 subfield was dissected from epileptic patients with (n=5) or without (n=2) hippocampal sclerosis (HS). COX-2 expression was investigated using immunohistochemistry and semi-quantitative RT-PCR. COX-2 immunoreactivity in TLE patient material in the absence of HS was restricted to a few neurons of the hippocampus. In the presence of HS, on the other hand, a significant induction of astrocytic COX-2 immunoreactivity associated with a concomitant increase in the steady-state level of COX-2 mRNA was observed in the CA1 subfield. These findings suggest that induction of astrocytic COX-2 is implicated in the pathogenesis of HS in TLE and is consistent with the previous findings of increased concentrations of prostaglandins in the cerebrospinal fluid of these patients. | en |
dcterms.language | eng | en |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Neurochemistry international | |
oaire.citationVolume | 42 | |
oaire.citationIssue | 4 | |
oaire.citationStartPage | 299 | |
oaire.citationEndPage | 303 |
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