Keeping cool in acute liver failure: rationale for the use of mild hypothermia
dc.contributor.author | Vaquero, Javier | |
dc.contributor.author | Rose, Christopher | |
dc.contributor.author | Butterworth, Roger | |
dc.date.accessioned | 2013-04-23T18:25:23Z | |
dc.date.available | 2013-04-23T18:25:23Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | http://hdl.handle.net/1866/9573 | |
dc.description.sponsorship | CR: CIHR-post-doctoral fellowship | en |
dc.subject | Acute liver failure | en |
dc.subject | Ammonia | en |
dc.subject | Ammoniac | en |
dc.subject | Brain edema | en |
dc.subject | Défaillance hépatique aigüe | en |
dc.subject | Hypothermia | en |
dc.subject | Hypothermie | en |
dc.subject | Oedème cérébral | en |
dc.title | Keeping cool in acute liver failure: rationale for the use of mild hypothermia | |
dc.type | Article | en |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Centre de recherche du CHUM | fr |
dc.identifier.doi | 10.1016/j.jhep.2005.05.039 | |
dcterms.abstract | Encephalopathy, brain edema and intracranial hypertension are neurological complications responsible for substantial morbidity/mortality in patients with acute liver failure (ALF), where, aside from liver transplantation, there is currently a paucity of effective therapies. Mirroring its cerebro-protective effects in other clinical conditions, the induction of mild hypothermia may provide a potential therapeutic approach to the management of ALF. A solid mechanistic rationale for the use of mild hypothermia is provided by clinical and experimental studies showing its beneficial effects in relation to many of the key factors that determine the development of brain edema and intracranial hypertension in ALF, namely the delivery of ammonia to the brain, the disturbances of brain organic osmolytes and brain extracellular amino acids, cerebro-vascular haemodynamics, brain glucose metabolism, inflammation, subclinical seizure activity and alterations of gene expression. Initial uncontrolled clinical studies of mild hypothermia in patients with ALF suggest that it is an effective, feasible and safe approach. Randomized controlled clinical trials are now needed to adequately assess its efficacy, safety, clinical impact on global outcomes and to provide the guidelines for its use in ALF. | en |
dcterms.language | eng | en |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Journal of hepatology | |
oaire.citationVolume | 43 | |
oaire.citationIssue | 6 | |
oaire.citationStartPage | 1067 | |
oaire.citationEndPage | 1077 |
Fichier·s constituant ce document
Ce document figure dans la ou les collections suivantes
Ce document diffusé sur Papyrus est la propriété exclusive des titulaires des droits d'auteur et est protégé par la Loi sur le droit d'auteur (L.R.C. (1985), ch. C-42). Il peut être utilisé dans le cadre d'une utilisation équitable et non commerciale, à des fins d'étude privée ou de recherche, de critique ou de compte-rendu comme le prévoit la Loi. Pour toute autre utilisation, une autorisation écrite des titulaires des droits d'auteur sera nécessaire.