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dc.contributor.authorZwingmann, Claudia
dc.contributor.authorChatauret, Nicolas
dc.contributor.authorRose, Christopher
dc.contributor.authorLeibfritz, Dieter
dc.contributor.authorButterworth, Roger F.
dc.date.accessioned2013-04-23T15:56:57Z
dc.date.available2013-04-23T15:56:57Z
dc.date.issued2004
dc.identifier.urihttp://hdl.handle.net/1866/9569
dc.subjectAcute liver failureen
dc.subjectBrain edemaen
dc.subjectDéfaillance hépatique aigüeen
dc.subjectDisorders of the nervous systemen
dc.subjectGlutamineen
dc.subjectHypothermiaen
dc.subjectHypothermieen
dc.subjectMaladies du système nerveux autonomeen
dc.subjectOedème cérébralen
dc.subjectOrganic osmolytesen
dc.subjectOsmolytes organiquesen
dc.titleSelective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia
dc.typeArticleen
dc.contributor.affiliationUniversité de Montréal. Faculté de médecinefr
dc.contributor.affiliationUniversité de Montréal. Faculté de médecine. Centre de recherche du CHUMfr
dc.identifier.doi10.1016/j.brainres.2003.11.048
dcterms.abstractThe principal cause of mortality in patients with acute liver failure (ALF) is brain herniation resulting from intracranial hypertension caused by a progressive increase of brain water. In the present study, ex vivo high-resolution 1H-NMR spectroscopy was used to investigate the effects of ALF, with or without superimposed hypothermia, on brain organic osmolyte concentrations in relation to the severity of encephalopathy and brain edema in rats with ALF due to hepatic devascularization. In normothermic ALF rats, glutamine concentrations in frontal cortex increased more than fourfold at precoma stages, i.e. prior to the onset of severe encephalopathy, but showed no further increase at coma stages. In parallel with glutamine accumulation, the brain organic osmolytes myo-inositol and taurine were significantly decreased in frontal cortex to 63\% and 67\% of control values, respectively, at precoma stages (p<0.01), and to 58\% and 67\%, respectively, at coma stages of encephalopathy (p<0.01). Hypothermia, which prevented brain edema and encephalopathy in ALF rats, significantly attenuated the depletion of myo-inositol and taurine. Brain glutamine concentrations, on the other hand, did not respond to hypothermia. These findings demonstrate that experimental ALF results in selective changes in brain organic osmolytes as a function of the degree of encephalopathy which are associated with brain edema, and provides a further rationale for the continued use of hypothermia in the management of this condition.en
dcterms.languageengen
UdeM.VersionRioxxVersion acceptée / Accepted Manuscript
oaire.citationTitleBrain research
oaire.citationVolume999
oaire.citationIssue1
oaire.citationStartPage118
oaire.citationEndPage123


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