Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia
dc.contributor.author | Zwingmann, Claudia | |
dc.contributor.author | Chatauret, Nicolas | |
dc.contributor.author | Rose, Christopher | |
dc.contributor.author | Leibfritz, Dieter | |
dc.contributor.author | Butterworth, Roger | |
dc.date.accessioned | 2013-04-23T15:56:57Z | |
dc.date.available | 2013-04-23T15:56:57Z | |
dc.date.issued | 2004 | |
dc.identifier.uri | http://hdl.handle.net/1866/9569 | |
dc.subject | Acute liver failure | en |
dc.subject | Brain edema | en |
dc.subject | Défaillance hépatique aigüe | en |
dc.subject | Disorders of the nervous system | en |
dc.subject | Glutamine | en |
dc.subject | Hypothermia | en |
dc.subject | Hypothermie | en |
dc.subject | Maladies du système nerveux autonome | en |
dc.subject | Oedème cérébral | en |
dc.subject | Organic osmolytes | en |
dc.subject | Osmolytes organiques | en |
dc.title | Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia | |
dc.type | Article | en |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine | fr |
dc.contributor.affiliation | Université de Montréal. Faculté de médecine. Centre de recherche du CHUM | fr |
dc.identifier.doi | 10.1016/j.brainres.2003.11.048 | |
dcterms.abstract | The principal cause of mortality in patients with acute liver failure (ALF) is brain herniation resulting from intracranial hypertension caused by a progressive increase of brain water. In the present study, ex vivo high-resolution 1H-NMR spectroscopy was used to investigate the effects of ALF, with or without superimposed hypothermia, on brain organic osmolyte concentrations in relation to the severity of encephalopathy and brain edema in rats with ALF due to hepatic devascularization. In normothermic ALF rats, glutamine concentrations in frontal cortex increased more than fourfold at precoma stages, i.e. prior to the onset of severe encephalopathy, but showed no further increase at coma stages. In parallel with glutamine accumulation, the brain organic osmolytes myo-inositol and taurine were significantly decreased in frontal cortex to 63\% and 67\% of control values, respectively, at precoma stages (p<0.01), and to 58\% and 67\%, respectively, at coma stages of encephalopathy (p<0.01). Hypothermia, which prevented brain edema and encephalopathy in ALF rats, significantly attenuated the depletion of myo-inositol and taurine. Brain glutamine concentrations, on the other hand, did not respond to hypothermia. These findings demonstrate that experimental ALF results in selective changes in brain organic osmolytes as a function of the degree of encephalopathy which are associated with brain edema, and provides a further rationale for the continued use of hypothermia in the management of this condition. | en |
dcterms.language | eng | en |
UdeM.VersionRioxx | Version acceptée / Accepted Manuscript | |
oaire.citationTitle | Brain research | |
oaire.citationVolume | 999 | |
oaire.citationIssue | 1 | |
oaire.citationStartPage | 118 | |
oaire.citationEndPage | 123 |
Files in this item
This item appears in the following Collection(s)
This document disseminated on Papyrus is the exclusive property of the copyright holders and is protected by the Copyright Act (R.S.C. 1985, c. C-42). It may be used for fair dealing and non-commercial purposes, for private study or research, criticism and review as provided by law. For any other use, written authorization from the copyright holders is required.