Abstract(s)
The maintenance of multiple wavelets appears to be a consistent
feature of atrial fibrillation (AF). In this paper, we investigate possible mechanisms of initiation and perpetuation of multiple wavelets in
a computer model of AF. We developed a simplified model of human
atria that uses an ionic-based membrane model and whose geometry
is derived from a segmented MRI dataset. The three-dimensional surface has a realistic size and includes obstacles corresponding to the
location of major vessels and valves, but it does not take into account
anisotropy. The main advantage of this approach is its ability to simulate long duration arrhythmias (up to 40 seconds). Clinically relevant
initiation protocols, such as single-site burst pacing, were used. The
dynamics of simulated AF were investigated in models with different action potential durations and restitution properties, controlled by
the conductance of the slow inward current in a modified Luo-Rudy
model. The simulation studies show that (1) single-site burst pacing
protocol can be used to induce wavebreaks even in tissue with uniform
membrane properties, (2) the restitution-based wavebreaks in an atrial
model with realistic size and conduction velocities are transient and (3)
a significant reduction in APD (even with apparently flat restitution)
increases the duration of AF.