Parcourir Faculté de médecine vétérinaire par auteur·e "Beaudry, Francis"
Voici les éléments 1-20 de 26
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Actinobacillus pleuropneumoniae induces SJPL cell cycle arrest in G2/M-phase and inhibits porcine reproductive and respiratory syndrome virus replication
Ferreira Barbosa, Jérémy A.; Labrie, Josée; Beaudry, Francis; Gagnon, Carl A.; Jacques, Mario (2015-12)Background: Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry and causes important economic losses. No effective antiviral drugs against it are commercially available. We recently ... -
Anandamide modulates thermal avoidance in caenorhabditis elegans through vanilloid and cannabinoid receptor interplay
Abdollahi, Marzieh; Ben Salem, Jennifer; Castaño Uruena, Jesus David; Beaudry, Francis (Springer, 2024-03-27)Understanding the endocannabinoid system in C. elegans may offer insights into basic biological processes and potential therapeutic targets for managing pain and inflammation in human. It is well established that anandamide modulates pain perception ... -
Antinociceptive activity of vanilloids in caenorhabditis elegans is mediated by the desensitization of the TRPV channel OCR-2 and specific signal transduction pathways
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (Springer, 2023-02-03)Vanilloids, including capsaicin and eugenol, are ligands of transient receptor potential channel vanilloid subfamily member 1 (TRPV1). Prolonged treatment with vanilloids triggered the desensitization of TRPV1, leading to analgesic or antinociceptive ... -
Assessment of meat authenticity using bioinformatics, targeted peptide biomarkers and high-resolution mass spectrometry
Ruiz Orduna, Alberto; Husby, Erik; Yang, Charles T.; Ghosh, Dipankar; Beaudry, Francis (2015-10-01)In recent years, we observed a significant increase of food fraud ranging from false label claims to the use of additives and fillers to increase profitability. Recently in 2013, horse and pig DNA were detected in beef products sold from several ... -
Assessment of Tandem Mass Spectrometry and High Resolution Mass Spectrometry for the Analysis of Bupivacaine in Plasma
Gaudette, Fleur; Benito, Javier; Steagall, Paulo; Beaudry, Francis (2015-11-01)Triple quadrupole mass spectrometers coupled with high performance liquid chromatography are workhorses in quantitative bioanalyses. It provides substantial benefits including reproducibility, sensitivity and selectivity for trace analysis. Selected ... -
Cannabidiol and tetrahydrocannabinol antinociceptive activity is mediated by distinct receptors in caenorhabditis elegans
Boujenoui, Fatma; Nkambeu, Bruno; Ben Salem, Jennifer; Castaño Uruena, Jesus David; Beaudry, Francis (Springer, 2023-11-22)Cannabis has gained popularity in recent years as a substitute treatment for pain following the risks of typical treatments uncovered by the opioid crisis. The active ingredients frequently associated with pain-relieving effects are the phytocannabinoids ... -
Cannflavins isolated from cannabis sativa impede caenorhabditis elegans response to noxious heat
Lahaise, Mathilde; Boujenoui, Fatma; Beaudry, Francis (Springer, 2023-07-22)Cannflavins, flavonoids abundantly present in Cannabis sativa, possess a distinct chemical structure comprising a vanillyl group. Notably, the capsaicin structure also contains a vanillyl group, which is considered essential for interacting with the ... -
Capsaicin and Its analogues impede nocifensive response of caenorhabditis elegans to noxious heat
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (2020-05-05)Capsaicin is the most abundant pungent molecule identifed in red chili peppers, and it is widely used for food favoring, in pepper spray for self-defense devices and recently in ointments for the relief of neuropathic pain. Capsaicin and several other ... -
Characterization of Endoproteolytic Processing of Dynorphins by Proprotein Convertases using Mouse Spinal Cord S9 Fractions and Mass Spectrometry
Ruiz Orduna, Alberto; Beaudry, Francis (2016-06-01)Dynorphins are important neuropeptides with a central role in nociception and pain alleviation. Many mechanisms regulate endogenous dynorphin concentrations, including proteolysis. Proprotein convertases (PCs) are widely expressed in the central nervous ... -
Eugenol and other vanilloids hamper caenorhabditis elegans response to noxious heat
Nkambeu, Bruno; Ben Salem, Jennifer; Beaudry, Francis (Springer, 2020-10-29)Eugenol, a known vanilloid, was frequently used in dentistry as a local analgesic in addition, antibacterial and neuroprotective effects were also reported. Eugenol, capsaicin and many vanilloids are interacting with the transient receptor potential ... -
Evaluation of multiple reaction monitoring cubed for the analysis of tachykinin related peptides in rat spinal cord using a hybrid triple quadrupole–linear ion trap mass spectrometer
Pailleux, Floriane; Beaudry, Francis (2014-02)Targeted peptide methods generally use HPLC-MS/MRM approaches. Although dependent on the instrumental resolution, interferences may occur while performing analysis of complex biological matrices. HPLC-MS/MRM3 is a technique, which provides a significantly ... -
The fecal presence of enterotoxin and F4 genes as an indicator of efficacy of treatment with colistin sulfate in pigs
Rhouma, Mohamed; Fairbrother, John Morris; Thériault, William; Beaudry, Francis; Bergeron, Nadia; Laurent-Lewandowski, Sylvette; Letellier, Ann (2017)Background : Enterotoxigenic Escherichia coli (ETEC) strains producing multiple enterotoxins are important causes of post-weaning diarrhea (PWD) in pigs. The aim of the present study was to investigate the fecal presence of ETEC enterotoxin as well ... -
Gastric stability and oral bioavailability of colistin sulfate in pigs challenged or not with Escherichia coli O149: F4 (K88)
Rhouma, Mohamed; Beaudry, Francis; Thériault, William; Bergeron, Nadia; Laurent-Lewandowski, Sylvette; Fairbrother, John Morris; Letellier, Ann (2015-10)The aim of the present study was to investigate the in vitro gastric stability of colistin sulfate (CS) and its antimicrobial activity against Escherichia coli and to study the impact of ETEC O149: F4 (K88) infection in pigs on CS intestinal absorption. ... -
Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells
Hathroubi, Skander; Beaudry, Francis; Provost, Chantale; Martelet, Léa; Segura, Mariela; Gagnon, Carl A.; Jacques, Mario (SAGE, 2016-05-25)Actinobacillus pleuropneumoniae (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on both biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined the role of APP ... -
Impact of Actinobacillus pleuropneumoniae biofilm mode of growth on the lipid A structures and stimulation of immune cells
Hathroubi, Skander; Beaudry, Francis; Provost, Chantale; Martelet, Léa; Segura, Mariela; Gagnon, Carl A.; Jacques, Mario (2016-05-25)Actinobacillus pleuropneumoniae (APP), the etiologic agent of porcine pleuropneumonia, forms biofilms on biotic and abiotic surfaces. APP biofilms confers resistance to antibiotics. To our knowledge, no studies have examined the role of APP biofilm in ... -
Impaired EAT-4 vesicular glutamate transporter leads to defective nocifensive response of caenorhabditis elegans to noxious heat
Leonelli, Sophie; Nkambeu, Bruno; Beaudry, Francis (Springer, 2019-04-26)In mammals, glutamate is an important excitatory neurotransmitter. Glutamate and glutamate receptors are found in areas specifically involved in pain sensation, transmission and transduction such as peripheral nervous system, spinal cord and brain. ... -
In Vitro Ketamine CYP3A Mediated Metabolism Study using Mammalian Liver S9 Fractions, cDNA Expressed Enzymes and Liquid Chromatography Tandem Mass Spectrometry
Santamaria, Raphaël; Pailleux, Floriane; Beaudry, Francis (2014-12-01)Ketamine is widely used in medicine in combination with several benzodiazepines including midazolam. The objectives of this study were to develop a novel HPLC-MS/SRM method capable of quantifying ketamine and norketamine using an isotopic dilution ... -
Is nontargeted data acquisition for target analysis (nDATA) in mass spectrometry a forward-thinking analytical approach?
Abdollahi, Marzieh; Segura, Pedro A.; Beaudry, Francis (Wiley, 2022-10-21)Targeted mass spectrometry is extensively used for the quantitative measurement of various molecules present in complex matrices. It is certainly one of the most important analytical duties in a mass spectrometry laboratory. Systematic development of ... -
Liquid Chromatography-Electrospray Linear Ion Trap Mass Spectrometry Analysis of Targeted Neuropeptides in Tac1-/- Mouse Spinal Cords Reveal Significant Lower Concentration of Opioid Peptides
Saidi, Mouna; Beaudry, Francis (2015-08)Tachykinin and opioid peptides play a central role in pain transmission, modulation and inhibition. The treatment of pain is very important in medicine and many studies using NK1 receptor antagonists failed to show significant analgesic effects in ... -
Post weaning diarrhea in pigs: risk factors and non‑colistin‑based control strategies
Rhouma, Mohamed; Fairbrother, John Morris; Beaudry, Francis; Letellier, Ann (2017)Post-weaning diarrhea (PWD) is one of the most serious threats for the swine industry worldwide. It is commonly associated with the proliferation of enterotoxigenic Escherichia coli in the pig intestine. Colistin, a cationic antibiotic, is widely used ...